Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene

Ecotoxicology

Volumn 21, Issue 3, 2012, Pages 820-831

  Ruiz, Pamela ^a   Orbea, Amaia ^a   Rotchell, Jeanette M ^b   Cajaraville, Miren P ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF HULL   (United Kingdom)

Author keywords

Cancer related genes; Heavy fuel oil; Mussel; Mutation analysis; Styrene; Transcriptional responses; Turbot

Indexed keywords

CYCLIN G1; FUEL OIL; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PROTEIN P53; RAS PROTEIN; STYRENE;

CANCER; CARCINOGEN; GENETIC ANALYSIS; GENOTOXICITY; HEAVY OIL; MOLLUSC; MUTAGENICITY; OIL SPILL; PAH; POLLUTION EFFECT; POLLUTION EXPOSURE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; CYCLIN G1 GENE; DNA REPAIR; DOWN REGULATION; ECOTOXICITY; EXOCRINE GLAND; EXPOSURE; GADD45A GENE; GENE; GENE MUTATION; GENETIC TRANSCRIPTION; JUVENILE ANIMAL; LIVER; MUSSEL; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; P53 GENE; PRIORITY JOURNAL; SPECIES COMPARISON; TURBOT; UPREGULATION;

ANIMALS; FLATFISHES; FUEL OILS; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION, NEOPLASTIC; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MYTILUS EDULIS; NEOPLASM PROTEINS; RAS PROTEINS; SPECIES SPECIFICITY; STYRENE; TUMOR SUPPRESSOR PROTEIN P53; WATER POLLUTANTS, CHEMICAL;

MYTILUS EDULIS; SCOPHTHALMIDAE; SCOPHTHALMUS MAXIMUS;

EID: 84862844869     PISSN: 09639292     EISSN: 15733017     Source Type: Journal    
DOI: 10.1007/s10646-011-0843-6     Document Type: Article

References (56)

1. Aas E, Baussant T, Balk L, Liewenborg B, Andersen OK (2000) PAH metabolites in bile, cytochrome P4501A and DNA adducts as environmental risk parameters for chronic oil exposure: a laboratory experiment with Atlantic cod. Aquat Toxicol 51:241-258 (Pubitemid 32412104)
2. Abu-Qare AW, Abou-Donia MB (2001) Biomarkers of apoptosis: release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-20-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene. J Toxicol Environ Health Crit Rev 4B: 313-332 (Pubitemid 32701729)
3. Alzaga R, Montuori P, Ortiz L, Bayona JM, Albaigés J (2004) Fast solid-phase extraction-gas chromatography-mass spectrometry procedure for oil fingerprinting application to the Prestige oil spill. J Chromatogr 1025A:133-138 (Pubitemid 37548457)
4. Banni M, Negri A, Rebelo M, Rapallo F, Boussetta H, Viarengo A, Dondero F (2009) Expression analysis of the molluscan p53 protein family mRNA in mussels (Mytilus spp.) exposed to organic contaminants. Comp Biochem Physiol C Toxicol Pharmacol 149:414-418
5. Barber BJ (2004) Neoplastic diseases of commercially important marine bivalves. Aquat Living Resour 17:449-466 (Pubitemid 40059480)
6. Baršiene J (1994) Chromosome set changes in molluscs from highly polluted habitats. In: Beaumont A (ed) Genetics and evolution of aquatic organisms. Chapman and Hall, London, pp 434-446
7. Bates S, Rowan S, Vousden KH (1996) Characterisation of human cyclin G1 and G2: DNA damage inducible genes. Oncogene 13:1103-1109 (Pubitemid 26329098)
8. Beyer J, Jonsson G, Porte C, Krahn MM, Arise F (2010) Analytical methods for determining metabolites of polycyclic aromatic hydrocarbon (PAH) pollutants in fish bile: a review. Environ Toxicol Pharmacol 30:224-244
9. Bhaskaran A, May D, Rand-Weaver M, Tyler CR (1999) Fish p53 as a possible biomarker for genotoxins in the aquatic environment. Environ Mol Mutagen 33:177-184 (Pubitemid 29215613)
10. Bilbao E, Cajaraville MP, Cancio I (2010a) Differential transcription of genes involved in peroxisome proliferation in thicklip grey mullets Chelon labrosus injected with benzo(a)pyrene. Comp Biochem Physiol C Toxicol Pharmacol 151:334-342
11. Bilbao E, Raingeard D, Diaz de Cerio O, Ortiz-Zarragoitia M, Ruiz P, Izagirre U, Orbea A, Marigómez I, Cajaraville MP, Cancio I (2010b) Effects of exposure to Prestige-like heavy fuel oil and to perfluorooctane sulfonate on conventional biomarkers and target gene transcription in the thicklip grey mullet Chelon labrosus. Aquat Toxicol 98:282-296
12. Bolognesi C, Frenzilli G, Lasagna C, Perrone E, Roggieri P (2004) Genotoxicity biomarkers in Mytilus galloprovincialis: wild versus caged mussels. Mutat Res 552:153-162 (Pubitemid 39036823)
13. Böttger S, Jerszyk E, Low B, Walker C (2008) Genotoxic stressinduced expression of p53 and apoptosis in leukemic clam hemocytes with cytoplasmically sequestered p53. Cancer Res 68:777-782 (Pubitemid 351206754)
14. Buday L, Downward J (2008) Many faces of Ras activation. Biochim Biophys Acta 1786:178-187
15. Cachot J, Galgani F, Vincent F (1998) cDNA cloning and expression analysis of flounder p53 tumour suppressor gene. Comp Biochem Physiol B Biochem Mol Biol 121:235-242 (Pubitemid 28563216)
16. Cachot J, Couteau J, Frebourg T, Leboulenger F, Flaman J-M (2004) Functional analysis of chemically-induced mutations at the flounder TP53 locus, the FACIM assay. Mutat Res 552:51-60 (Pubitemid 39036817)
17. Cajaraville MP, Hauser L, Carvalho G, Hylland K, Olabarrieta I, Lawrence AJ, Lowe D, Goksøyr A (2003) Genetic damage and molecular/cellular response to pollution. In: Lawrence AJ, Hemingway KL (eds) Effects of pollution on fish. Blackwell Science Ltd, Oxford, p 179
18. Carls MG, Rice SD, Hose JE (1999) Sensitivity of fish embryos to weathered crude oil: part 1. Low-level exposure during incubation causes malformations, genetic damage, and mortality in larval Pacific herring (Clupea pallasi). Environ Toxicol Chem 18:481-493 (Pubitemid 29091738)
19. Chen S, Hong Y, Scherer SJ, Schartl M (2001) Lack of ultravioletlight inducibility of the medakafish (Oryzias latipes) tumor suppressor gene p53. Gene 264:197-203 (Pubitemid 32206640)
20. Ciocan CM, Rotchell JM (2005) Conservation of cancer genes in the marine invertebrate Mytilus edulis. Environ Sci Technol 39:3029-3033 (Pubitemid 40638241)
21. Ciocan CM, Moore JD, Rotchell JM (2006) The role of ras gene in the development of haemic neoplasia in Mytilus trossulus. Mar Environ Res 62:147-150
22. Hahn ME, Woodin BR, Stegeman JJ, Tillitt DE (1998) Aryl hydrocarbon receptor function in early vertebrates: inducibility of cytochrome P4501A in agnathan and elasmobranch fish. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 120: 67-75 (Pubitemid 28398888)
23. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70 (Pubitemid 30046295)
24. Hollander MC, Fornace AJ Jr (2002) Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a. Oncogene 21:6228-6233
25. International Agency for Research on Cancer (IARC) (1989) Occupational exposures in petroleum refining: crude oil and major petroleum fuels. IARC Monographs on the evaluation of carcinogenic risk to humans. International Agency for Research on Cancer, vol 45. Lyon, p 322
26. Jin SG, Guo C, Pfeifer GP (2008) GADD45A does not promote DNA demethylation. PLoS Genet 4:e100013
27. Kelley ML, Winge P, Heaney JD, Stephens RE, Farell JH, Van Beneden RJ, Reinisch CL, Lesser MP, Walker CW (2001) Expression of homologues for p53 and p73 in the softshell clam (Mya arenaria), a naturally-occurring model for human cancer. Oncogene 20:748-758 (Pubitemid 32179343)
28. Kim SJ, Ko CB, Park C, Kim BR, Sung TH, Koh DH, Kim NS, Oh KJ, Chung SY, Park R (2005) p38 MAP kinase regulatesbenzo(a)pyrene-induced apoptosis through the regulation of p53 activation. Arch Biochem Biophys 444:121-129 (Pubitemid 41728344)
29. Kirby MF, Law RJ (2010) Accidental spills at sea-risk, impact, mitigation and the need for co-ordinated post-incident monitoring. Mar Environ Bull 60:797-803
30. Laffon B, Pásaro E, Méndez J (2001a) Genotoxic effects of styrene-7,8-oxide in human white blood cells: comet assay in relation to the induction of sister-chromatid exchanges and micronuclei. Mutat Res 491:163-172 (Pubitemid 32245838)
31. Laffon B, Pásaro E, Méndez J (2001b) Effects of styrene-7,8-oxide over p53, p21, bcl-2 and bax expression in human lymphocyte cultures. Mutagenesis 16:127-132 (Pubitemid 32184475)
32. Lam SH, Gong Z (2006) Modeling liver cancer using zebrafish, a comparative oncogenomics approach. Cell Cycle 6:573-577
33. Law RJ, Kelly C, Matthiessen P, Aldridge J (2003) The loss of the chemical tanker Ievoli Sun in the English Channel, October 2000. Mar Pollut Bull 46:254-257 (Pubitemid 36173829)
34. Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323-331 (Pubitemid 27131374)
35. Liebermann DA, Hoffman B (2007) Gadd45 in the response of hematopoietic cells to genotoxic stress. Blood Cells Mol Dis 39: 329-335 (Pubitemid 47484472)
36. Lima I, Peck MR, Rendón-Von Osten J, Soares AMVM, Guilhermino L, Rotchell JM (2008) Ras gene in marine mussels: a molecular level response to petrochemical exposure. Mar Pollut Bull 56: 633-640
37. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCT method. Methods 25:402-408 (Pubitemid 34164012)
38. Luch A, Baird WM (2010) Carcinogenic polycyclic aromatic hydrocarbons. Compr Toxicol 14:85-123
39. Mamaca E, Bechmann RK, Torgrimsen S, Aas E, Bjornstad A, Baussant T, Floch SL (2005) The neutral red lysosomal retention assay and comet assay on haemolymph cells from mussels (Mytilus edulis) and fish (Symphodus melops) exposed to styrene. Aquat Toxicol 75:191-201 (Pubitemid 41456673)
40. Muttray AF, Schulte PM, Baldwin SA (2008) Invertebrate p53-like mRNA isoforms are differentially expressed in mussel haemic neoplasia. Mar Environ Res 66:412-421
41. Muttray AF, O'Tolee TF, Morrill W, Van Beneden RJ, Baldwin SA (2010) An invertebrate mdm homolog interacts with p53 and is differentially expressed together with p53 and ras in neoplastic Mytilus trossulus haemocytes. Comp Biochem Physiol B Biochem Mol Biol 156:298-308
42. Nesnow S, Ross JA, Stoner GD, Mass MJ (1995) Mechanistic linkage between DNA adducts, mutations in oncogenes and tumorigenesis of carcinogenic environmental polycyclic aromatic hydrocarbons in strain A/J mice. Toxicology 105:403-413 (Pubitemid 26038265)
43. Nogueira P, Lourenco J, Mendo S, Rotchell JM (2006) Mutation analysis of ras gene in the liver of European eel (Anguilla anguilla L.) exposed to benzo[a]pyrene. Mar Pollut Bull 52:1611-1616 (Pubitemid 44809304)
44. Nogueira P, Pacheco M, Pereira MJ, Mendo S, Rotchell JM (2010) Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination. Environ Pollut 158:1783-1790
45. Okamoto K, Prives C (1999) A role of cyclin G in the process of apoptosis. Oncogene 18:4606-4615 (Pubitemid 29405892)
46. Rotchell JM, Ostrander GK, Myers, DE Hinton, DiGiulio R (2008) Carcinogenesis in fish. In: DiGiulio RT, DE Hinton (eds) Toxicology of fishes. CRC Press, Boca Raton
47. Rueff J, Teixera JP, Silva L, Gaspar JF (2009) Genetic effects and biotoxicity monitoring of occupational styrene exposure. Clin Chim Acta 399:8-23
48. Short JW, Heintz RA (1997) Identification of Exxon Valdez oil in sediments and tissues from Prince William Sound and the northwesters Gulf of Alaska Based on a PAH weathering model. Environ Sci Technol 31:2375-2384 (Pubitemid 27343916)
49. Siafakas AR, Richardson DR (2009) Growth arrest and DNA damage-45 alpha (GADD45a). Int J Biochem Cell Biol 41:986-989
50. Štifanić M, Mičić M, Ramšak A, Blašković S, Ruso A, Zahn RK, Batel R (2009) p63 in Mytilus galloprovincialis and p53 family members in the phylum Mollusca. Comp Biochem Physiol B Biochem Mol Biol 154:264-273
51. Sumner JS, Fennell TR (1994) Review of the metabolic fate of styrene. Crit Rev Toxicol 24:S11-S33 (Pubitemid 24352042)
52. Vogelstein B, Lane D, Levine AJ (2000) Surfing the p53 network. Nature 408:307-310
53. Walker C, Bottger S, Low B (2006) Mortalin-based cytoplasmic sequestration of p53 in a non mammalian cancer model. Am J Pathol 168:1526-1530
54. Wilson I, Gamble M (2002) The hematoxylins and eosin. In: Bancroft JD, Gamble M (eds) Theory and practice of histological techniques. Churchill Livingstone-Elsevier Science Ltd, London, p 796
55. Yardley G, Zauberman A, Oren M, Jackson P (1998) Individual promoter and intron p53-binding motifs from the rat cyclin G1 promoter region support transcriptional activation by p53 but do not show co-operative activation. FEBS Lett 430:171-175 (Pubitemid 28337906)
56. Zerbini LF, Wang Y, Correa RG, Cho J-Y, Liebermann TA (2005) Blockage of NF-kB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells. Cell Cycle 9: 1247-1253 (Pubitemid 41365397)