Cutting-edge issues in autoimmune orchitis

Clinical Reviews in Allergy and Immunology

Volumn 42, Issue 2, 2012, Pages 256-263

  Silva, Clovis A ^a   Cocuzza, Marcello ^a   Borba, Eduardo F ^a   Bonfá, Eloísa ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antisperm antibodies; Autoimmune orchitis; Fertility; Orchitis; Testicle

Indexed keywords

FAS LIGAND; GAMMA INTERFERON; HLA DR6 ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PREDNISOLONE; SPERM ANTIBODY; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

ANAPHYLACTOID PURPURA; APOPTOSIS; AUTOIMMUNE DISEASE; AUTOIMMUNE ORCHITIS; BEHCET DISEASE; CLINICAL FEATURE; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE ACTIVITY; DISEASE CLASSIFICATION; DISEASE SEVERITY; FERTILIZATION IN VITRO; HISTOPATHOLOGY; HUMAN; IMMUNOPATHOGENESIS; IMMUNOSUPPRESSIVE TREATMENT; INTRACYTOPLASMIC SPERM INJECTION; INTRAUTERINE INSEMINATION; MALE; MALE FERTILITY; MALE INFERTILITY; MICROENVIRONMENT; NERVE BLOCK; OLIGOSPERMIA; ORCHITIS; PATHOGENESIS; POLYARTERITIS NODOSA; REVIEW; SERTOLI CELL; SPERMATID; SPERMATOCYTE; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SYSTEMIC LUPUS ERYTHEMATOSUS; TREATMENT DURATION; UVEITIS; ZONA PELLUCIDA;

APOPTOSIS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC TESTS, ROUTINE; FERTILITY; HUMANS; INCIDENCE; MALE; ORCHITIS; PREVALENCE; SPERMATOZOA; TESTIS;

EID: 84862838074     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-011-8281-z     Document Type: Review

References (89)

1. Silva CA, Brunner HI (2007) Gonadal functioning and preserva-tion of reproductive fitness with juvenile systemic lupus eryth-ematosus. Lupus 16:593-599 (Pubitemid 47359994)
2. Silva CA, Bonfa E, Ostensen M (2010) Maintenance offertility in patients with rheumatic diseases needing anti-inflammatory and immunosuppressive drugs. Arthritis Care Res (Hoboken) 62:1682-1690
3. Revel A, Revel-Vilk S (2008) Pediatric fertility preservation: is it time to offer testicular tissue cryopreservation? Mol Cell Endo-crinol 282:143-149
4. Silva CA, Hallak J, Pasqualotto FF, Barba MF, Saito MI, Kiss MH (2002) Gonadal function in male adolescents and young males with juvenile onset systemic lupus erythematosus. J Rheumatol 29:2000-2005 (Pubitemid 34988712)
5. Suehiro RM, Borba EF, Bonfa E, Okay TS, Cocuzza M, Soares PM, Silva CA (2008) Testicular Sertoli cell function in male systemic lupus erythematosus. Rheumatology (Oxford) 47:1692-1697
6. Moraes AJ, Pereira RM, Cocuzza M, Casemiro R, Saito O, Silva CA (2008) Minor sperm abnormalities in young male post-pubertal patients withjuvenile dermatomyositis. Braz J Med Biol Res 41:1142-1147
7. Sallum AM, Garcia AJ, Saito OC, Silva CA (2009) Scrotum and testicular calcinosis in juvenile dermatomyositis (JDM). A report of two cases. Clin Exp Rheumatol 27:382-383
8. Moraes AJ, Bonfa E, Cocuzza M, Borges CT, Saito O, Silva CA (2010) Gonad evaluation in male dermatomyositis. A pilot study. Clin Exp Rheumatol 28:441-442
9. Balen AH, Rutherford AJ (2007) Management of infertility BMJ 335:608-611 (Pubitemid 47509857)
10. Rowe T (2006) Fertility and a woman's age. J Reprod Med 51:157-163
11. Bong GW, Koo HP (2004) The adolescent varicocele: to treat or not to treat. Urol Clin North Am 31:509-515, ix (Pubitemid 39093935)
12. Folomeev M, Alekberova ZS (1990) Impotence in systemic lupus erythematosus. JRheumatol 17:117-119
13. Athreya BH, Rafferty JH, Sehgal GS, Lahita RG (1993) Adenohypophyseal and sex hormones in pediatric rheumatic diseases. J Rheumatol 20:725-730 (Pubitemid 23138868)
14. Vilarinho ST, Costallat LT (1998) Evaluation of the hypothalamic- pituitary-gonadal axis in males with systemic lupus erythemato-sus. J Rheumatol 25:1097-1103
15. Mok CC, Lau CS (2000) Profile of sex hormones in male patients with systemic lupus erythematosus. Lupus 9:252-257 (Pubitemid 30261066)
16. Walker G, Merry P, Sethia K, Ball RY (2000) A case of testicular lupus. Lupus 9:397-398 (Pubitemid 30389047)
17. Latta K, von Schnakenburg C, Ehrich JH (2001) A meta-analysis of cytotoxic treatment for frequently relapsing nephrotic syndrome in children. Pediatr Nephrol 16:271-282 (Pubitemid 32229852)
18. Meistrich ML, Wilson G, Brown BW, da Cunha MF, Lipshultz LI (1992) Impact of cyclophosphamide on long-term reduction in sperm count in men treated with combination chemotherapy for Ewing and soft tissue sarcomas. Cancer 70:2703-2712
19. Ostensen M, Lockshin M, Doria A, Valesini G, Meroni P, Gordon C, Brucato A, Tincani A (2008) Update on safety during pregnancy of biological agents and some immunosuppressive anti-rheumatic drugs. Rheumatology (Oxford) 47(Suppl 3):iii28-iii31
20. Ostensen M, Khamashta M, Lockshin M, Parke A, Brucato A, Carp H, Doria A, Rai R, Meroni P, Cetin I, Derksen R, Branch W, Motta M, Gordon C, Ruiz-Irastorza G, Spinillo A, Friedman D, Cimaz R, Czeizel A, Piette JC, Cervera R, Levy RA, Clementi M, De Carolis S, Petri M, Shoenfeld Y, Faden D, Valesini G, Tincani A (2006) Anti-inflammatory and immunosuppressive drugs and reproduction. Arthritis Res Ther 8:209
21. Vecchi AP, Borba EF, Bonfa E, Cocuzza M, Pieri P, Kim CA, Silva CA (2011) Penile anthropometry in systemic lupus erythematosus. Lupus 20:512-518
22. Soares PM, Borba EF, Bonfa E, Hallak J, Correa AL, Silva CA (2007) Gonad evaluation in male systemic lupus erythematosus. Arthritis Rheum 56:2352-2361 (Pubitemid 47173583)
23. Schuppe HC, Meinhardt A, Allam JP, Bergmann M, Weidner W, Haidl G (2008) Chronic orchitis: a neglected cause of male infertility? Andrologia 40:84-91 (Pubitemid 351379679)
24. Østensen M, Brucato A, Carp H, Chambers C, Dolhain R, Doria A, Förger F, Gordon C, Hahn S, Khamashta M, Lockshin M, Matucci-Cerinic M, Meroni PL, Nelson JL, Parke A, Petri M, Ruiz-Irastorza G, Raio L, Silva CA, Tincani A, Villiger PM, Wunder D, Cutolo M (2010) Pregnancy and reproduction in autoimmune rheumatic diseases. Rheumatology (Oxford) 50:657-664
25. Silva CA, Borba E, Cocuzza M, Carvalho J, Bonfá E (2008) Autoimmune orchitis. In: Shoenfeld Y, Gershwin ME (eds) Diagnostic criteria in autoimmune diseases, 1st edn. Springer Science, California, pp 281-284
26. Fijak M, Meinhardt A (2006) The testis in immune privilege. Immunol Rev 213:66-81 (Pubitemid 44401494)
27. Krause W (2008) Male accessory gland infection. Andrologia 40:113-116 (Pubitemid 351379667)
28. Shibahara H, Koriyama J, Shiraishi Y, Hirano Y, Suzuki M, Koyama K (2009) Diagnosis and treatment of immunologically infertile women with sperm-immobilizing antibodies in their sera. J Reprod Immunol 83:139-144
29. Taneichi A, Shibahara H, Hirano Y, Suzuki T, Obara H, Fujiwara H, Takamizawa S, Sato I (2002) Sperm immobilizing antibodies in the sera of infertile women cause low fertilization rates and poor embryo quality in vitro. Am J Reprod Immunol 47:46-51 (Pubitemid 34552374)
30. Agarwal A, Bragais FM, Sabanegh E (2008) Assessing sperm function. Urol Clin North Am 35:157-171, vii (Pubitemid 351514781)
31. Shefi S, Turek PJ (2006) Definition and current evaluation of subfertile men. Int Braz J Urol 32:385-397 (Pubitemid 44430353)
32. Arap MA, Vicentini FC, Cocuzza M, Hallak J, Athayde K, Lucon AM, Arap S, Srougi M (2007) Late hormonal levels, semen parameters and presence of antisperm antibodies in patients treated for testicular torsion. J Androl 28:528-532 (Pubitemid 47057034)
33. Bhasin S (2007) Approach to the infertile man. J Clin Endocrinol Metab 92:1995-2004
34. Shiraishi Y Shibahara H, Koriyama J, Hirano Y, Okazaki H, Minota S, Suzuki M (2009) Incidence of antisperm antibodies in males with systemic autoimmune diseases. Am J Reprod Immunol 61:183-189
35. D'Cruz OJ, Haas GG Jr, Reichlin M (1994) Autoantibodies to decondensed sperm nuclear deoxyribonucleic acid in patients with antisperm antibodies and systemic lupus erythematosus detected by immunofluorescence flow cytometry. Fertil Steril 62:834-844 (Pubitemid 24307582)
36. Kuehn MW, Oellinger R, Kustin G, Merkel KH (1989) Primary testicular manifestation ofsystemic lupus erythematosus. Eur Urol 16:72-73 (Pubitemid 19061096)
37. MacIver H, Hordon L (2009) An unusual case of testicular pain. Clin Rheumatol 28:351-352
38. Boulis ER, Majithia V (2011) Orchitis in lupus/scleroderma overlap syndrome: a case report and literature review. Can J Urol 17:5306-5308
39. Pannek J, Haupt G (1997) Orchitis due to vasculitis in autoimmune diseases. Scand J Rheumatol 26:151-154 (Pubitemid 27286483)
40. Pastor-Navarro H, Broseta-Viana L, Donate-Moreno MJ, Pastor-Guzman JM, Lorenzo-Romero JG, Segura-Martin M, Salinas-Sanchez AS, Virseda-Rodriguez JA (2007) Isolated testicular polyarteritis nodosa. Urology 70(178):e7-e8
41. Persellin ST, Menke DM (1992) Isolated polyarteritis nodosa of the male reproductive system. J Rheumatol 19:985-988
42. Fraenkel-Rubin M, Ergas D, Sthoeger ZM (2002) Limited polyarteritis nodosa of the male and female reproductive systems: diagnostic and therapeutic approach. Ann Rheum Dis 61:362-364 (Pubitemid 34257751)
43. Pagnoux C, Seror R, Henegar C, Mahr A, Cohen P, Le Guern V, Bienvenu B, Mouthon L, Guillevin L (2010) Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study ofpatients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database. Arthritis Rheum 62:616-626
44. Kaklamani VG, Vaiopoulos G, Markomichelakis N, Kaklamanis P (2000) Recurrent epididymo-orchitis in patients with Behcet's disease. J Urol 163:487-489 (Pubitemid 30060501)
45. De Almeida JL, Campos LM, Paim LB, Leone C, Koch VH, Silva CA (2007) Renal involvement in Henoch-Schonlein purpura: a multivariate analysis ofinitial prognostic factors. J Pediatr (Rio J) 83:259-266 (Pubitemid 46883826)
46. Ha TS, Lee JS (2007) Scrotal involvement in childhood Henoch-Schonlein purpura. Acta Paediatr 96:552-555
47. Fijak M, Bhushan S, Meinhardt A (2011) Immunoprivileged sites: the testis. Methods Mol Biol 677:459-470
48. Guazzone VA, Jacobo P, Theas MS, Lustig L (2009) Cytokines and chemokines in testicular inflammation: a brief review. Microsc Res Tech 72:620-628
49. Fijak M, Iosub R, Schneider E, Linder M, Respondek K, Klug J, Meinhardt A (2005) Identification of immunodominant autoan-tigens in rat autoimmune orchitis. J Pathol 207:127-138 (Pubitemid 41404143)
50. Rival C, Guazzone VA, Theas MS, Lustig L (2005) Pathomechanism of autoimmune orchitis. Andrologia 37:226-227
51. Hedger MP, Meinhardt A (2003) Cytokines and the immune-testicular axis. J Reprod Immunol 58:1-26 (Pubitemid 36279148)
52. Jacobo P, Guazzone VA, Theas MS, Lustig L (2011) Testicular autoimmunity. Autoimmun Rev 10:201-204
53. Filippini A, Riccioli A, Padula F, Lauretti P, DAlessio A, De Cesaris P, Gandini L, Lenzi A, Ziparo E (2001) Control and impairment of immune privilege in the testis and in semen. Hum Reprod Update 7:444-449 (Pubitemid 32827543)
54. Theas S, Rival C, Lustig L (2003) Germ cell apoptosis in autoimmune orchitis: involvement of the Fas-FasL system. Am J Reprod Immunol 50:166-176 (Pubitemid 36903312)
55. Wu H, Wang H, Xiong W, Chen S, Tang H, Han D (2008) Expression patterns and functions of toll-like receptors in mouse sertoli cells. Endocrinology 149:4402-4412
56. Naito M, Itoh M (2008) Patterns of infiltration of lymphocytes into the testis under normal and pathological conditions in mice. Am J Reprod Immunol 59:55-61 (Pubitemid 350285583)
57. Mayer DF, Matteson EL (2004) Testicular involvement in rheumatoid vasculitis. Clin Exp Rheumatol 22:S62-S64
58. Agarwal A, Said TM (2005) Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach. BJU Int 95:503-507 (Pubitemid 40311459)
59. Cocuzza M, Sikka SC, Athayde KS, Agarwal A (2007) Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis. Int Braz J Urol 33:603-621
60. Sakkas D, Mariethoz E, Manicardi G, Bizzaro D, Bianchi PG, Bianchi U (1999) Origin of DNA damage in ejaculated human spermatozoa. Rev Reprod 4:31-37 (Pubitemid 29078542)
61. Henkel R, Hajimohammad M, StalfT, Hoogendijk C, Mehnert C, Menkveld R, Gips H, Schill WB, Kruger TF (2004) Influence of deoxyribonucleic acid damage on fertilization and pregnancy. Fertil Steril 81:965-972 (Pubitemid 38452959)
62. Agarwal A, Allamaneni SS (2004) The effect of sperm DNA damage on assisted reproduction outcomes. A review. Minerva Ginecol 56:235-245 (Pubitemid 38981266)
63. Tomsu M, Sharma V, Miller D (2002) Embryo quality and IVF treatment outcomes may correlate with different sperm comet assay parameters. Hum Reprod 17:1856-1862 (Pubitemid 34790313)
64. Eggert-Kruse W, Hofsass A, Haury E, Tilgen W, Gerhard I, Runnebaum B (1991) Relationship between local anti-sperm antibodies and sperm-mucus interaction in vitro and in vivo. Hum Reprod 6:267-276
65. Omu AE, al-Qattan F, Mohammed A (1996) Expression of human leukocyte antigens in patients with autogenic and allogenic circulating antisperm antibodies. Arch Androl 37:155-162 (Pubitemid 26397956)
66. Rumke P, Hellinga G (1959) Autoantibodies against spermatozoa in sterile men. Am J Clin Pathol 32:357-363
67. Practice Committee of the American Society for Reproductive Medicine (2006) Definition of"infertility". Fertil Steril 86:S228
68. Billingham RE, Brent L, Medawar PB (1953) Actively acquired tolerance offoreign cells. Nature 172:603-606
69. Hendry WF, Morgan H, Stedronska J (1977) The clinical significance of antisperm antibodies in male subfertility Br J Urol 49:757-762 (Pubitemid 8243614)
70. Hendry WF (1992) The significance of antisperm antibodies: measurement and management. Clin Endocrinol (Oxf) 36:219-221
71. Walsh TJ, Turek PJ (2009) Immunologic infertility. In: Lipshultz LI, Stuart SH, Niederberger CS (eds) Infertility in the male, 4th edn. Cambridge University Press, United Kingdom, pp 277-294
72. WHO (1999) World Health Organization: WHO Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. Cambridge University Press, New York
73. Prando D (2009) Torsion of the spermatic cord: the main gray-scale and Doppler sonographic signs. Abdom Imaging 34:648-661
74. Sharquie KE (1984) Suppression of Behcet's disease with dapsone. Br J Dermatol 110:493-494 (Pubitemid 14132498)
75. Haidl G (2002) Management strategies for male factor infertility. Drugs 62:1741-1753 (Pubitemid 34948173)
76. Hendry WF, Hughes L, Scammell G, Pryor JP, Hargreave TB (1990) Comparison ofprednisolone and placebo in subfertile men with antibodies to spermatozoa. Lancet 335:85-88 (Pubitemid 20018705)
77. Naz RK (2004) Modalities for treatment of antisperm antibody mediated infertility: novel perspectives. Am J Reprod Immunol 51:390-397 (Pubitemid 38765275)
78. Adeghe AJ (1987) Effect ofwashing on sperm surface autoanti-bodies. Br J Urol 60:360-363 (Pubitemid 17147562)
79. Ombelet W, Vandeput H, Janssen M, Cox A, Vossen C, Pollet H, Steeno O, Bosmans E (1997) Treatment ofmale infertility due to sperm surface antibodies: IUI orIVF? Hum Reprod 12:1165-1170 (Pubitemid 27273537)
80. Turek PJ, Lipshultz LI (1994) Immunologic infertility Urol Clin North Am 21:447-468 (Pubitemid 24266861)
81. Daitoh T, Kamada M, Yamano S, Murayama S, Kobayashi T, Maegawa M, Aono T (1995) High implantation rate and consequently high pregnancy rate by in vitro fertilization-embryo transfer treatment in infertile women with antisperm antibody. Fertil Steril 63:87-91
82. Vazquez-Levin MH, Notrica JA, Polak de Fried E (1997) Male immunologic infertility: sperm performance on in vitro fertiliza-tion. Fertil Steril 68:675-681 (Pubitemid 27454329)
83. Check JH (2007) Treatment of male infertility. Clin Exp Obstet Gynecol 34:201-206
84. Junk SM, Matson PL, Yovich JM, Bootsma B, Yovich JL (1986) The fertilization of human oocytes by spermatozoa from men with antispermatozoal antibodies in semen. J In Vitro Fert Embryo Transf3:350-352 (Pubitemid 17224368)
85. Kamada M, Yamano S, Senuma M, Nakagawa K, Maegawa M, Aono T (1998) Semen analysis and antisperm antibody. Arch Androl 40:117-128 (Pubitemid 28120253)
86. Esteves SC, Schneider DT, Verza S Jr (2007) Influence of antisperm antibodies in the semen on intracytoplasmic sperm injection outcome. Int Braz J Urol 33:795-802
87. Nagy ZP, Verheyen G, Liu J, Joris H, Janssenswillen C, Wisanto A, Devroey P, Van Steirteghem AC (1995) Results of 55 intracytoplasmic sperm injection cycles in the treatment of male-immunological infertility. Hum Reprod 10:1775-1780
88. Lahteenmaki A, Reima I, Hovatta O (1995) Treatment of severe male immunological infertility by intracytoplasmic sperm injec-tion. Hum Reprod 10:2824-2828
89. Culligan PJ, Crane MM, Boone WR, Allen TC, Price TM, Blauer KL (1998) Validity and cost-effectiveness of antisperm antibody testing before in vitro fertilization. Fertil Steril 69:894-898 (Pubitemid 28193926)