Synthesis and biological evaluation of 21-arylidenepregnenolone derivatives as neuroprotective agents

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 6, 2012, Pages 2226-2229

  Jiang, Cheng Shi ^a   Guo, Xian Jun ^a   Gong, Jing Xu ^a   Zhu, Ting Ting ^a   Zhang, Hai Yan ^a   Guo, Yue Wei ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

21 Arylidenepregnenolone derivatives; Amyloid peptide; Neuroprotective activity; Oxidative stress; Oxygen glucose deprivation

Indexed keywords

21 ARYLIDENEPREGNENOLONE DERIVATIVE; 3 BETA PREGN 21 BENZYLIDENE 20 ONE; AMYLOID BETA PROTEIN[25-35]; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENT; PREGNENOLONE; PREGNENOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NEUROPROTECTION; NEUROTOXICITY;

AMYLOID BETA-PEPTIDES; ANIMALS; CELL HYPOXIA; CELL SURVIVAL; DRUG DESIGN; GLUCOSE; HUMANS; HYDROGEN PEROXIDE; NEUROPROTECTIVE AGENTS; OXYGEN; PC12 CELLS; PREGNENOLONE; RATS;

EID: 84862830240     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.103     Document Type: Article

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