Synthesis and evaluation of some 16-benzylidene substituted 3,17-dioximino androstene derivatives as anticancer agents

Letters in Drug Design and Discovery

Volumn 2, Issue 7, 2005, Pages 537-545

  Dubey, Sonal ^a   Piplani, Poonam ^b   Jindal, Dharam P ^b  

^a Karnatak Lingayat Education Society   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

Anticancer; Dehydroepiandrosterone; Oxime; Steroidal

Indexed keywords

16 (2 PYRIDYLMETHYLENE) 3,17 DIOXIMINO 4 ANDROSTENE; 16 (3 PYRIDYLMETHYLENE) 3,17 DIOXIMINO 4 ANDROSTENE; 16 (3,4 DIMETHOXYBENZYLIDENE) 3,17 DIOXIMINO 4 ANDROSTENE; 16 (4 ISOPROPYLBENZYLIDENE) 3,17 DIOXIMINO 4 ANDROSTENE; 16 (4 METHOXYBENZYLIDENE) 3,17 DIOXIMINO 4 ANDROSTENE; 16 (4 NITROBENZYLIDENE) 3,17 DIOXIMINO 4 ANDROSTENE; 16 [3 METHOXY 4 (2 MORPHOLIN 4 YLETHOXY)BENZYLIDENE] 3,17 DIOXIMINO 4 ANDROSTENE; 16 [4 (2 DIMETHYLAMINOETHOXY) 3 METHOXYBENZYLIDENE] 3,17 DIOXIMINO 4 ANDROSTENE; ANTINEOPLASTIC AGENT; BENZYLIDENE DERIVATIVE; S 716260; S 716564; S 718283; S 718810; S 722348; S 723377; S 724180; UNCLASSIFIED DRUG;

ALDOL REACTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CANCER; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL STRAIN MCF 7; CELL STRAIN NCI H460; CELL STRAIN SF 268; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; PRIORITY JOURNAL;

EID: 28444446236     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018005774479186     Document Type: Article

References (18)

1. th edition, pp.345, Delgado, J.N.; Remers, W.A. Ed.; J.B. Lippincott Co., 1991.
2. Vogel, C.L. Anticancer Drugs 2003, 14 (4), 265-273.
3. Chabner, B.A.; Ryan, D.P.; Paz-Ares, L.; Gracia-Carbonero, R.; Calabresi, P. in 'Goodman and Oilman's The Pharmacological Basis of Therapeutics', 10th edition, pp. 1389-1408, Ed. J.G. Hardman and L.E. Limbird, McGraw-Hill Companies Inc., 2001.
4. Bedir, E.; Khan, I.A.; walker, L.A. Pharmazie 2002, 57, 491-493.
5. Kuo, K.W.; Hsu, S.H.; Li, Y.P.; Iin, W.L.; Liu, L.F.; Chang, L.C.; Lin, C.N.; Sheu, H.M. Biochem. Pharmacol. 2000, 60, 1865-1873.
6. Luo, L.; Li, Z.; Zhang, Y.; Huang, R. Yao Xue Xue Bao. 1998, 33, 839-842.
7. Brodie, A.M.H.; Coombes, R.C.; Dowsett, M. J. Steroid Biochem. 1987, 27, 899-903.
8. Budzar, A. U. Clin. Breast Cancer 2003, (Suppl. 2), S84-S88.
9. Dixon, J.M. Exp. Opin. Pharmacother. 2004, 5(2), 307-316.
10. Papageoriou, A.; Tsavdaridis, D.; Geromichalos, G.D.; Camoutsis, C.; Karaberis, E.; Mourelatos, D.; Chrysogelou, E.; Houvartas, S.; Kotsis, A. Cancer Detect Prev. 2001, 25, 369-374.
11. Beusen, D.D.; Carrell, H.L.; Covey, D.F. Biochemistry 1987, 26, 7833-7841.
12. Brueggemier, R.W. Am. J. Ther. 2001, 8(5), 333-344.
13. O'Reilly, J.M.; Brueggemeier, R. W. J. Steroid Biochem. Mol. Biol. 1996, 59(1), 93-102.
14. Rodriguez, J.; Nunez, L.; Peixinho, S.; Jimenez, C. Tetrahedron Lett. 1997,38, 1833.
15. Deive, N.; Rodriguez, J.; Jimenez, C. J. Med. Chem. 2001, 44, 2612-2618.
16. Christiansen, R.G.; Clinton, R.O.; Dean, J. W. U.S. Pat. 316364, 1964, [Chem. Abstr. 1965, 62, 7834].
17. Easthem, J.F.; Taranishi, R. 'In Organic Synthesis', Vol.2, pp.1-28, Adams, R., Ed.; John Wiley and Sons, Inc: New York, 1960.
18. Hershberg, E. B. J. Org. Chem., 1948, 13, 542-546.