Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 4, 2012, Pages 1468-1474

  Narumi, Tetsuo ^a   Komoriya, Mao ^a   Hashimoto, Chie ^a   Wu, Honggui ^b,c   Nomura, Wataru ^a   Suzuki, Shintaro ^a   Tanaka, Tomohiro ^a   Chiba, Joe ^c   Yamamoto, Naoki ^d   Murakami, Tsutomu ^b   Tamamura, Hirokazu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Anti HIV; Matrix protein; Octa arginyl group; Overlapping peptide

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CELL PENETRATING PEPTIDE; MATRIX PROTEIN; PROTEIN P17;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; IMMUNOFLUORESCENCE TEST; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; CELL MEMBRANE PERMEABILITY; CELL-PENETRATING PEPTIDES; CIRCULAR DICHROISM; HELA CELLS; HIV; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84862829668     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.055     Document Type: Article

References (29)

1. A.K. Ghosh, Z.L. Dawson, and H. Mitsuya Bioorg. Med. Chem. 15 2007 7576
2. P. Cahn, and O. Sued Lancet 369 2007 1235
3. B. Grinsztejn, B.-Y. Nguyen, C. Katlama, J.M. Gatell, A. Lazzarin, D. Vittecoq, C.J. Gonzalez, J. Chen, C.M. Harvey, and R.D. Isaacs Lancet 369 2007 1261
4. H. Tamamura, Y. Xu, T. Hattori, X. Zhang, R. Arakaki, K. Kanbara, A. Omagari, A. Otaka, T. Ibuka, N. Yamamoto, H. Nakashima, and N. Fujii Biochem. Biophys. Res. Commun. 253 1998 877
5. N. Fujii, S. Oishi, K. Hiramatsu, T. Araki, S. Ueda, H. Tamamura, A. Otaka, S. Kusano, S. Terakubo, H. Nakashima, J.A. Broach, J.O. Trent, Z. Wang, and S.C. Peiper Angew. Chem., Int. Ed. 42 2003 3251
6. H. Tamamura, K. Hiramatsu, M. Mizumoto, S. Ueda, S. Kusano, S. Terakubo, M. Akamatsu, N. Yamamoto, J.O. Trent, Z. Wang, S.C. Peiper, H. Nakashima, A. Otaka, and N. Fujii Org. Biomol. Chem. 1 2003 3663
7. T. Tanaka, W. Nomura, T. Narumi, A. Masuda, and H. Tamamura J. Am. Chem. Soc. 132 2010 15899
8. Y. Yamada, C. Ochiai, K. Yoshimura, T. Tanaka, N. Ohashi, T. Narumi, W. Nomura, S. Harada, S. Matsushita, and H. Tamamura Bioorg. Med. Chem. Lett. 20 2010 354
9. T. Narumi, C. Ochiai, K. Yoshimura, S. Harada, T. Tanaka, W. Nomura, H. Arai, T. Ozaki, N. Ohashi, S. Matsushita, and H. Tamamura Bioorg. Med. Chem. Lett. 20 2010 5853
10. K. Yoshimura, S. Harada, J. Shibata, M. Hatada, Y. Yamada, C. Ochiai, H. Tamamura, and S. Matsushita J. Virol. 84 2010 7558
11. A. Otaka, M. Nakamura, D. Nameki, E. Kodama, S. Uchiyama, S. Nakamura, H. Nakano, H. Tamamura, Y. Kobayashi, M. Matsuoka, and N. Fujii Angew. Chem., Int. Ed. 41 2002 2937
12. S. Suzuki, E. Urano, C. Hashimoto, H. Tsutsumi, T. Nakahara, T. Tanaka, Y. Nakanishi, K. Maddali, Y. Han, M. Hamatake, K. Miyauchi, Y. Pommier, J.A. Beutler, W. Sugiura, H. Fuji, T. Hoshino, K. Itotani, W. Nomura, T. Narumi, N. Yamamoto, and J.A. Komano J. Med. Chem. 53 2010 5356
13. S. Suzuki, K. Maddali, C. Hashimoto, E. Urano, N. Ohashi, T. Tanaka, T. Ozaki, H. Arai, H. Tsutsumi, T. Narumi, W. Nomura, N. Yamamoto, Y. Pommier, J.A. Komano, and H. Tamamura Bioorg. Med. Chem. 18 2010 6771
14. E.O. Freed Virology 251 1998 1
15. A. Bukrinskaya Virus Res. 124 2007 1
16. M. Niedrig, H.R. Gelderblom, G. Pauli, J. März, H. Bickhard, H. Wolf, and S. Modrow J. Gen. Virol. 75 1994 1469
17. P.M. Cannon, S. Matthews, N. Clark, E.D. Byles, O. Iourin, D.J. Hockley, S.M. Kingsman, and A.J. Kingsman J. Virol. 71 1997 3474
18. Y. Morikawa, T. Kishi, W.H. Zhang, M.V. Nermut, D.J. Hockley, and I.M. Jones J. Virol. 69 1995 4519
19. T. Suzuki, S. Futaki, M. Niwa, S. Tanaka, K. Ueda, and Y. Sugiura J. Biol. Chem. 277 2002 2437
20. P.A. Wender, D.J. Mitchell, K. Pattabiraman, E.T. Pelkey, L. Steinman, and J.B. Rothbard Proc. Natl. Acad. Sci. U.S.A. 97 2000 13003
21. M. Matsushita, K. Tomizawa, A. Moriwaki, S.T. Li, H. Terada, and H. Matsui J. Neurosci. 21 2001 6000
22. T. Takenobu, K. Tomizawa, M. Matsushita, S.T. Li, A. Moriwaki, Y.F. Lu, and H. Matsui Mol. Cancer Ther. 1 2002 1043
23. H.Y. Wu, K. Tomizawa, M. Matsushita, Y.F. Lu, S.T. Li, and H. Matsui Neurosci. Res. 47 2003 131
24. J.B. Rothbard, S. Garlington, Q. Lin, T. Kirschberg, E. Kreider, P.L. McGrane, P.A. Wender, and P.A. Khavari Nat. Med. 6 2000 1253
25. A. Ono J. Virol. 78 2004 1552
26. Z. Rao, A.S. Belyaev, E. Fry, P. Roy, I.M. Jones, and D.I. Stuart Nature 378 1995 743
27. C.P. Hill, D. Worthylake, D.P. Bancroft, A.M. Christensen, and W.I. Sundquist Proc. Natl. Acad. Sci. U.S.A. 93 1996 3099
28. B.N. Kelly, B.R. Howard, H. Wang, H. Robinson, W.I. Sundquist, and C.P. Hill Biochemistry 45 2006 11257
29. C. Murdoch, P.N. Monk, and A. Finn Immunology 98 1999 36