Peptidic HIV integrase inhibitors derived from HIV gene products: Structure-activity relationship studies

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 18, 2010, Pages 6771-6775

  Suzuki, Shintaro ^a   Maddali, Kasthuraiah ^b   Hashimoto, Chie ^a   Urano, Emiko ^c   Ohashi, Nami ^a   Tanaka, Tomohiro ^a   Ozaki, Taro ^a   Arai, Hiroshi ^a   Tsutsumi, Hiroshi ^a   Narumi, Tetsuo ^a   Nomura, Wataru ^a   Yamamoto, Naoki ^c,d   Pommier, Yves ^b   Komano, Jun A ^c   Tamamura, Hirokazu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Ala scan; Glu Lys pairs; HIV integrase; Inhibitory peptide

Indexed keywords

ALANINE; AMINO ACID; ARGININE; GENE PRODUCT; GLUTAMIC ACID; INTEGRASE INHIBITOR; LYSINE; PEPTIDE DERIVATIVE; PEPTIDE LIBRARY;

ALPHA HELIX; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; NONHUMAN; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CELL LINE; CIRCULAR DICHROISM; GLUTAMIC ACID; HIV INTEGRASE INHIBITORS; HUMANS; LYSINE; MOLECULAR SEQUENCE DATA; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; VPR GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77956339915     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.050     Document Type: Article

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