Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide

Journal of Translational Medicine

Volumn 10, Issue 1, 2012, Pages

  Duarte, Julio D ^a,b   Zineh, Issam ^a,c   Burkley, Ben ^a   Gong, Yan ^a   Langaee, Taimour Y ^a   Turner, Stephen T ^d   Chapman, Arlene B ^e   Boerwinkle, Eric ^f   Gums, John G ^a   Cooper DeHoff, Rhonda M ^a   Beitelshees, Amber L ^g   Bailey, Kent R ^d   Fillingim, Roger B ^a   Kone, Bruce C ^a,h   Johnson, Julie A ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d MAYO CLINIC   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF TEXAS   (United States)

Author keywords

Blood pressure; DOT1L; Histone methylation; Hydrochlorothiazide; Hypertension; MLLT3; Pharmacogenetics; Pharmacogenomics; SGK1; SIRT1

Indexed keywords

ATENOLOL; HYDROCHLOROTHIAZIDE; ANTIHYPERTENSIVE AGENT; HISTONE; LYSINE;

ADULT; AFRICAN AMERICAN; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CAUCASIAN; COHORT ANALYSIS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DNA METHYLATION; DOT1L GENE; DRUG RESPONSE; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; H3K9 GENE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MARKER GENE; MLLT3 GENE; PHARMACOGENOMICS; RACE DIFFERENCE; RANDOMIZED CONTROLLED TRIAL; REGULATOR GENE; SGK1 GENE; SIRT1 GENE; SYSTOLIC BLOOD PRESSURE; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DEMOGRAPHY; DRUG EFFECT; GENETICS; GENOTYPE; METABOLISM; METHYLATION; MIDDLE AGED; MULTICENTER STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT OUTCOME;

AFRICAN AMERICANS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; COHORT STUDIES; DEMOGRAPHY; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HISTONES; HUMANS; HYDROCHLOROTHIAZIDE; LYSINE; MALE; METHYLATION; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TREATMENT OUTCOME;

EID: 84862828371     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-10-56     Document Type: Article

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