Iodoacetic acid, but not sodium iodate, creates an inducible swine model of photoreceptor damage

Experimental Eye Research

Volumn 97, Issue 1, 2012, Pages 137-147

  Noel, Jennifer M ^a,b   Fernandez de Castro, Juan P ^a   DeMarco Jr , Paul J ^a   Franco, Luisa M ^a   Wang, Wei ^a   Vukmanic, Eric V ^a   Peng, Xiaoyan ^a,d   Sandell, Julie H ^c   Scott, Patrick A ^a,c   Kaplan, Henry J ^a   McCall, Maureen A ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Electrophysiology; Iodoacetic acid; Multi focal ERG; Porcine eye; Retina; Retinal degeneration; Retinitis Pigmentosa

Indexed keywords

IODOACETIC ACID; SODIUM IODATE;

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DARK ADAPTATION; ELECTRORETINOGRAPHY; EXPERIMENTAL MODEL; EXPERIMENTAL PIG; EYE FUNDUS; GLYCEMIC CONTROL; HISTOLOGY; LIGHT ADAPTATION; NONHUMAN; OPTIC DISK; PHOTORECEPTOR CELL; PRIORITY JOURNAL; RETINA BIPOLAR GANGLION CELL; RETINA BLOOD VESSEL; RETINA CONE; RETINA INJURY; RETINA ROD; VISION;

ANIMALS; BLOOD GLUCOSE; DARK ADAPTATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRORETINOGRAPHY; ENZYME INHIBITORS; INFUSIONS, INTRAVENOUS; IODATES; IODOACETIC ACID; PHOTIC STIMULATION; PHOTORECEPTOR CELLS, VERTEBRATE; RETINAL DEGENERATION; SUS SCROFA;

EID: 84862827104     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.12.018     Document Type: Article

References (44)

1. Ashburn F.S., Pilkerton A.R., Rao N.A., Marak G.E. The effects of iodate and iodoacetate on the retinal adhesion. Investigative Ophthamology and Visual Science 1980, 19:1427-1432.
2. Baehr W., Frederick J.M. Naturally occurring animal models with outer retina phenotypes. Vision Research 2009, 49(22):2636-2652.
3. Baich A., Ziegler M. The effect of sodium iodate and melanin on the formation of glyoxylate. Pigment Cell Research 1992, 5:394-395.
4. Barron J.T., Kopp S.J., Tow J.P., Messer J.V. Effects of altering carbohydrate metabolism on energy status and contractile function of vascular smooth muscle. Biochimica et Biophysica Acta 1989, 976(1):42-52.
5. Beauchemin M.L. The fine structure of the pig's retina. [Comparative Study]. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology 1974, 190(1):27-45.
6. Berson E.L. Retinitis Pigmentosa. The Friedenwald Lecture. Investigative Ophthalmology and Visual Science 1993, 34(5):1659-1676.
7. Birrer L. Zur Histochemie der Natriumjodat- und Natriumjodazetet-Retinopathie. Ophthalmologica 1970, 160:176-194.
8. Chandler M.J., Smith P.J., Samuelson D.A., MacKay E.O. Photoreceptor density of the domestic pig retina. Veterinary Ophthalmology 1999, 2(3):179-184.
9. Chen X., Wikler K.C., MacLeish P.R. Cone properties of retinal margin cells in the monkey (Macaca mulatta). Investigative Ophthalmology & Visual Science 2000, 41(8):2019-2022.
10. Corbett A.D., Lees G.M. Depressant effects of hypoxia and hypoglycaemia on neuro-effector transmission of guinea-pig intestine studied in vitro with a pharmacological model. British Journal of Pharmacology 1997, 120(1):107-115.
11. Del Priore L.V., Kaplan H.J., Hornbeck R., Jones Z., Swinn M. Retinal pigment epithelial debridement as a model for pathogenesis and treatment of macular degeneration. American Journal of Ophthalmology 1996, 122:629-643.
12. Dryja T.P., Berson E.L. Retinitis Pigmentosa and allied diseases. Implications of genetic heterogeneity. [Review]. Investigative Ophthalmology & Visual Science 1995, 36(7):1197-1200.
13. Ekser, B., Ezzelarab, M., Hara, H., van der Windt, D.J., Wijkstrom, M., Bottino, R., Trucco, M., Cooper, D.K., Clinical xenotransplantation: the next medical revolution? Lancet, in press.
14. Enzmann V., Howard R.M., Yamauchi Y., Whittemore S.R., Kaplan H.J. Enhanced induction of RPE lineage markers in pluripotent neural stem cells engrafted into the adult rat subretinal space. Investigative Ophthalmology & Visual Science 2003, 44(12):5417-5422.
15. Enzmann V., Row B.W., Yamauchi Y., Kheirandish L., Gozal D., Kaplan H.J., McCall M.A. Behavioral and anatomical abnormalities in a sodium iodate-induced model of retinal pigment epithelium degeneration. Experimental Eye Research 2006, 82(3):441-448.
16. Farber D.B., Souza D.W., Chase D.G. Cone visual cell degeneration in ground squirrel retina: disruption of morphology and cyclic nucleotide metabolism by iodoacetic acid. Investigative Ophthalmology & Visual Science 1983, 24:1236-1249.
17. Franco L.M., Zulliger R., Wolf-Schnurrbusch U.E., Katagiri Y., Kaplan H.J., Wolf S., Enzmann V. Decreased visual function after patchy loss of retinal pigment epithelium induced by low-dose sodium iodate. Investigative Ophthalmology & Visual Science 2009, 50(8):4004-4010. [Research Support, Non-U.S. Gov't].
18. Garcá M., Ruiz-Ederra J., Hernández-Barbáchano H., Vecino E. Topography of pig retinal ganglion cells. The Journal of Comparative Neurology 2005, 486(4):361-372.
19. Gerke C.G., Hao Y., Wong F. Topography of rods and cones in the retina of the domestic pig. Hong Kong Medical Journal 1995, 1(4):302-308.
20. Graymore C., Tansley K. Iodoacetate poisoning of the rat retina. I. Production of retinal degeneration. British Journal of Ophthalmology 1959, 43:177-185.
21. Grignolo A. Rhodopsin cycle and fine structure of rabbit retina in experimental degeneration induced by retinotoxic agents. Experimental Eye Research 1969, 8(2):254.
22. Hayasaka S., Noda S., Setogawa T. Effect of drugs in vitro on lysosonal enzyme activities in bovine retinal pigment epithelial cells. Japanese Journal of Ophthalmology 1988, 32:316-321.
23. Hendrickson A., Hicks D. Distribution and density of medium- and short-wavelength selective cones in the domestic pig retina. Experimental Eye Research 2002, 74(4):435-444.
24. Joselevitch C., Kamermans M. Interaction between rod and cone inputs in mixed-input bipolar cells in goldfish retina. Journal of Neuroscience Research 2007, 85(7):1579-1591.
25. Kyhn M.V., Kiilgaard J.F., Lopez A.G., Scherfig E., Prause J.U., la Cour M. Functional implications of short-term retinal detachment in porcine eyes: study by multifocal electroretinography. Acta Ophthalmologica 2008, 86(1):18-25.
26. Lalonde M.R., Chauhan B.C., Tremblay F. Retinal ganglion cell activity from the multifocal electroretinogram in pig: optic nerve section, anaesthesia and intravitreal tetrodotoxin. The Journal of Physiology 2006, 570:325-338.
27. Li Y., Reca R.G., Atmaca-Sonmez P., Ratajczak M.Z., Ildstad S.T., Kaplan H.J., Enzmann V. Retinal pigment epithelium damage enhances expression of chemoattractants and migration of bone marrow-derived stem cells. Investigative Ophthalmology & Visual Science 2006, 47(4):1646-1652.
28. Liang L., Katagiri Y., Franco L.M., Yamauchi Y., Enzmann V., Kaplan H.J., Sandell J.H. Long-term cellular and regional specificity of the photoreceptor toxin, iodoacetic acid (IAA), in the rabbit retina. Visual Neuroscience 2008, 25(2):167-177.
29. Marc R.E., Jones B.W., Watt C.B., Strettoi E. Neural remodeling in retinal degeneration. Progress in Retinal and Eye Research 2003, 22:607-655.
30. Marmor M.F., Fulton A.B., Holder G.E., Miyake Y., Brigell M., Bach M. ISCEV standard for full-field clinical electroretinography (2008 update). Documenta Ophthalmologica 2009, 118(1):69-77.
31. Mecklenburg L., Schraermeyer U. An overview on the toxic morphological changes in the retinal pigment epithelium after systemic compound administration. Toxicologic Pathology 2007, 35:252-267.
32. Moren H., Gesslein B., Andreasson S., Malmsjo M. Multifocal electroretinogram for functional evaluation of retinal injury following ischemia-reperfusion in pigs. Graefe's Archive for Clinical and Experimental Ophthalmology 2010, 248(5):627-634.
33. Noell W.K. The effect of iodoacetate on the vertebrate retina. Journal of Cellular and Comparative Physiology 1951, 37:283-307.
34. Noell W.K. Experimentally induced toxic effects on structure and function of visual cells and pigment epithelium. American Journal of Ophthalmology 1953, 36:103-116.
35. Orzalesi N., Calabria G.A., Grignolo A. Experimental degeneration of the rabbit retina induced by iodoacetic acid. A study of the ultrastructure, the rhodopsin cycle and the uptake of 14C-labeled iodoacetic acid. Experimental Eye Research 1970, 9(2):246-253.
36. Pearce-Kelling S.E., Aleman T.S., Nickle A., Laties A.M., Aguirre G.D., Jacobson S.G., Acland G.M. Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcd1 canine model of Retinitis Pigmentosa. Molecular Vision 2001, 7:42-47.
37. Petters R.M., Alexander C.A., Wells K.D., Collins E.B., Sommer J.R., Blanton M.R., Wong F. Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in Retinitis Pigmentosa. Nature Biotechnology 1997, 15(10):965-970.
38. Scott P.A., Kaplan H.J., Sandell J.H. Anatomical evidence of photoreceptor degeneration induced by iodoacetic acid in the porcine eye. Experimental Eye Research 2011, 93(4):513-527.
39. Shintani K., Shechtman D.L., Gurwood A.S. Review and update: current treatment trends for patients with Retinitis Pigmentosa. Optometry - Journal of the American Optometric Association 2009, 80(7):384-401.
40. Swindle M.M., Smith A. Information Resources for Swine in Biomedical Research 2000, US Department of Agriculture. C.P. Smith (Ed.).
41. Valentino T.L., Kaplan H.J., Del Priore L.V., Fang S., Berger A., Silverman M.S. Retinal pigment epithelial repopulation in monkeys after submacular surgery. Archives of Ophthalmology 1995, 113:932-938.
42. Wang W., Fernandez-de Castro J.P., Vukmanic E.V., Zhou L., Emery D., Kaplan H.J., Dean D.C. Selective rod degeneration and partial cone inactivation characterize an iodoacetic acid model of swine retinal degeneration. Investigative Ophthalmology and Vision Science 2011, 52(11):7917-7923.
43. Williams R.W. The human retina has a cone-enriched rim. Visual Neuroscience 1991, 6:403-406.
44. Winkler B.S., Sauer M.W., Starnes C.A. Modulation of the Pasteur effect in retinal cells: implications for understanding compensatory metabolic mechanisms. Experimental Eye Research 2003, 76(6):715-723.