Selective rod degeneration and partial cone inactivation characterize an iodoacetic acid model of swine retinal degeneration

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 11, 2011, Pages 7917-7923

  Wang, Wei ^a   de Castro, Juan Fernandez ^a   Vukmanic, Eric ^a   Zhou, Liang ^a   Emery, Douglas ^a   DeMarco, Paul J ^a,b   Kaplan, Henry J ^a   Dean, Douglas C ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IODOACETIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ELECTRORETINOGRAPHY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RETINA CONE; RETINA DEGENERATION; RETINA ROD; STAINING; SWINE; ANIMAL; CELL COUNT; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; CHROMOSOME PAIRING; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; FLUORESCENCE MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; INTRAVENOUS DRUG ADMINISTRATION; PATHOLOGY; PATHOPHYSIOLOGY; RETINA BIPOLAR GANGLION CELL; RETINA NERVE CELL;

ANIMALS; CELL COUNT; CELL SURVIVAL; CHROMOSOME PAIRING; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRORETINOGRAPHY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; INJECTIONS, INTRAVENOUS; IODOACETIC ACID; MALE; MICROSCOPY, FLUORESCENCE; RETINAL BIPOLAR CELLS; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL DEGENERATION; RETINAL NEURONS; RETINAL ROD PHOTORECEPTOR CELLS; SUS SCROFA;

EID: 84555189036     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7849     Document Type: Article

References (33)

1. Edwards AO, Ritter R 3rd, Abel KJ, Manning A, Panhuysen C, Farrer LA. Complement factor H polymorphism and age-related macular degeneration. Science. 2005;308:421-424.
2. Wang W, Dean DC, Kaplan HJ. Age-related macular degeneration. Discov Med. 2010;9:13-15.
3. Sung CH, Davenport CM, Hennessey JC, et al. Rhodopsin mutations in autosomal dominant retinitis pigmentosa. Proc Natl Acad Sci U S A. 1991;88:6481-6485.
4. Hamel C. Retinitis pigmentosa. Orphanet J Rare Dis. 2006;1:40.
5. Bhatti MT. Retinitis pigmentosa, pigmentary retinopathies, and neurologic diseases. Curr Neurol Neurosci Rep. 2006;6:403-413.
6. Ng YF, Chan HH, Chu PH, et al. Multifocal electroretinogram in rhodopsin P347L transgenic pigs. Invest Ophthalmol Vis Sci. 2008; 49:2208-2215.
7. Alexander KR, Barnes CS, Fishman GA. ON-pathway dysfunction and timing properties of the flicker ERG in carriers of X-linked retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2003;44:4017-4025.
8. Dalke C, Graw J. Mouse mutants as models for congenital retinal disorders. Exp Eye Res. 2005;81:503-512.
9. Olsson JE, Gordon JW, Pawlyk BS, et al. Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron. 1992;9:815-830.
10. Chang B, Heckenlively JR, Hawes NL, Roderick TH. New mouse primary retinal degeneration (rd-3). Genomics. 1993;16:45-49.
11. Szel A, Rohlich P, Caffe AR, Juliusson B, Aguirre G, Van Veen T. Unique topographic separation of two spectral classes of cones in the mouse retina. J Comp Neurol. 1992;325:327-342.
12. Roof DJ, Adamian M, Hayes A. Rhodopsin accumulation at abnormal sites in retinas of mice with a human P23H rhodopsin transgene. Invest Ophthalmol Vis Sci. 1994;35:4049-4062.
13. Beauchemin ML, Babel J. Proceedings: a preliminary study on the ultrastructure of the pig retina. Exp Eye Res. 1973;17:400.
14. Braekevelt CR. Fine structure of the retinal rods and cones in the domestic pig. Graefes Arch Clin Exp Ophthalmol. 1983;220:273-278.
15. Tso MO, Li WW, Zhang C, et al. A pathologic study of degeneration of the rod and cone populations of the rhodopsin Pro347Leu transgenic pigs. Trans Am Ophthalmol Soc. 1997;95:467-479, discussion 479-483.
16. Li ZY, Wong F, Chang JH, et al. Rhodopsin transgenic pigs as a model for human retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1998;39:808-819.
17. Harris JR, Brown GA, Jorgensen M, et al. Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury. Invest Ophthalmol Vis Sci. 2006;47:2108-2113.
18. Sengupta N, Caballero S, Sullivan SM, et al. Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair. Mol Ther. 2009;17:1594-1604.
19. Enzmann V, Row BW, Yamauchi Y, et al. Behavioral and anatomical abnormalities in a sodium iodate-induced model of retinal pigment epithelium degeneration. Exp Eye Res. 2006;82:441-448.
20. Winkler BS, Sauer MW, Starnes CA. Modulation of the Pasteur effect in retinal cells: implications for understanding compensatory metabolic mechanisms. Exp Eye Res. 2003;76:715-723.
21. Liang L, Katagiri Y, Franco LM, et al. Long-term cellular and regional specificity of the photoreceptor toxin, iodoacetic acid (IAA), in the rabbit retina. Vis Neurosci. 2008;25:167-177.
22. Noell WK. Experimentally induced toxic effects on structure and function of visual cells and pigment epithelium. Am J Ophthalmol. 1953;36:103-116.
23. Lasansky A, De Robertis E. Submicroscopic changes in visual cells of the rabbit induced by iodoacetate. J Biophys Biochem Cytol. 1959;5:245-250.
24. Noell WK. The impairment of visual cell structure by iodoacetate. J Cell Physiol. 1952;40:25-55.
25. Petters RM, Alexander CA, Wells KD, et al. Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa. Nat Biotechnol. 1997;15: 965-970.
26. Lalonde MR, Chauhan BC, Tremblay F. Retinal ganglion cell activity from the multifocal electroretinogram in pig: optic nerve section, anaesthesia and intravitreal tetrodotoxin. J Physiol. 2006;570: 325-338.
27. Marmor MF, Fulton AB, Holder GE, Miyake Y, Brigell M, Bach M. ISCEV Standard for full-field clinical electroretinography (2008 update). Doc Ophthalmol. 2009;118:69-77.
28. Terasaki H, Miyake K, Miyake Y. Reduced oscillatory potentials of the full-field electroretinogram of eyes with aphakic or pseudophakic cystoid macular edema. Am J Ophthalmol. 2003;135:477-482.
29. Oh EC, Cheng H, Hao H, Jia L, Khan NW, Swaroop A. Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors. Brain Res. 2008;1236:16-29.
30. Rehemtulla A, Warwar R, Kumar R, Ji X, Zack DJ, Swaroop A. The basic motif-leucine zipper transcription factor Nrl can positively regulate rhodopsin gene expression. Proc Natl Acad Sci U S A. 1996;93:191-195.
31. Alexander KR, Rajagopalan AS, Raghuram A, Fishman GA. Activation phase of cone phototransduction and the flicker electroretinogram in retinitis pigmentosa. Vision Res. 2006;46:2773-2785.
32. Graymore C, Tansley K. Iodoacetate poisoning of the rat retina, II: glycolysis in the poisoned retina. Br J Ophthalmol. 1959;43:486-493.
33. Orzalesi N, Calabria GA, Grignolo A. Experimental degeneration of the rabbit retina induced by iodoacetic acid: a study of the ultrastructure, the rhodopsin cycle and the uptake of 14C-labeled iodoacetic acid. Exp Eye Res. 1970;9:246-253.