In vivo and in vitro metabolism of tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), by the freshwater planarian, Dugesia japonica

Chemosphere

Volumn 87, Issue 11, 2012, Pages 1341-1347

  Wu, Jui Pin ^a   Li, Mei Hui ^a   Chen, Jhih Sheng ^b   Lee, Hui Ling ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

4 (Methylnitrosamino) 1 (3 pyridyl) 1 butanol (NNAL); 4 (Methylnitrosamino) 1 (3 pyridyl) 1 butanone (NNK); Aquatic organism; Carbonyl reduction; Planarian; Tobacco specific nitrosamine (TSNA)

Indexed keywords

BIOCHEMISTRY; CHEMICALS; HEALTH RISKS; KETONES; MAMMALS; METABOLISM; METABOLITES; SMOKE; TOBACCO; WATER;

4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANOL (NNAL); 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE (NNK); CARBONYL REDUCTION; PLANARIAN; TOBACCO SPECIFIC NITROSAMINES;

AQUATIC ORGANISMS;

1 (3 PYRIDYL) 1,4 BUTANEDIOL; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CARBONYL REDUCTASE; NITROSAMINE; UNCLASSIFIED DRUG;

AQUATIC ORGANISM; BIOACCUMULATION; CARBONYL COMPOUND; CHEMICAL POLLUTANT; DOSE-RESPONSE RELATIONSHIP; FLATWORM; FRESHWATER ECOSYSTEM; METABOLISM; PUBLIC HEALTH; RISK FACTOR; SMOKING; TOBACCO; TOXICITY TEST; TOXICOLOGY;

ACUTE TOXICITY; ANIMAL EXPERIMENT; AQUATIC ENVIRONMENT; ARTICLE; BIOACCUMULATION; CARBONYLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DUGESIA JAPONICA; HYDROXYLATION; METABOLISM; NONHUMAN; TISSUE LEVEL; TOBACCO; TURBELLARIA;

DUGESIA JAPONICA; MAMMALIA; NICOTIANA TABACUM; PLANARIA; TURBELLARIA;

EID: 84862826951     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2012.02.024     Document Type: Article

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