Enhancements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism and carcinogenic risk via NNK/arsenic interaction

Toxicology and Applied Pharmacology

Volumn 227, Issue 1, 2008, Pages 108-114

  Lee, Hui Ling ^a   Chang, Louis W ^a   Wu, Jui Pin ^a   Ueng, Yune Fang ^b   Tsai, Ming Hsien ^a   Hsieh, Dennis Paul Hsientang ^a   Lin, Pinpin ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Arsenic; Cigarette smoke; Cytochrome P450 2A; DNA adduct; NNK

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 6 O METHYLGUANINE; 7 METHYLGUANINE; ARSENITE SODIUM; CYTOCHROME P450 2A; CYTOCHROME P450 2A4; CYTOCHROME P450 2A5; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER RISK; CARCINOGENICITY; CONTROLLED STUDY; DNA ADDUCT; ENZYME ACTIVITY; HYDROXYLATION; MALE; MOUSE; NONHUMAN; TOXICOKINETICS; UPREGULATION; URINARY EXCRETION;

ANIMALS; ARSENIC; BODY WEIGHT; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; GROWTH; HYDROXYLATION; MALE; MICE; MICE, INBRED ICR; NITROSAMINES; RISK FACTORS; RNA, MESSENGER;

MUS;

EID: 38849141021     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.09.024     Document Type: Article

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