Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 6, 2012, Pages 2216-2220

  Yuan, Lei ^a   Li, Yanchun ^a   Zou, Chunyang ^b   Wang, Chao ^a   Gao, Jian ^a   Miao, Caixia ^a   Ma, Enlong ^a   Sun, Tiemin ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Liaoning College of Health Vocation and Technology   (China)

Author keywords

Aqueous solubility; Asperphenamate; Autophagy; Inducer; Structure activity relationships

Indexed keywords

ANTINEOPLASTIC AGENT; ASPERPHENAMATE DERIVATIVE; CISPLATIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CANCER CELL; CELL DEATH; CONTROLLED STUDY; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; PHENYLALANINE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862826370     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.101     Document Type: Article

References (18)

1. B. Levine, and D.J. Klionsky Dev. Cell 6 2004 463
2. A.J. Meijer, and P. Codogno Int. J. Biochem. Cell Biol. 36 2004 2445
3. R. Mathew, S. Kongara, B. Beaudoin, C.M. Karp, K. Bray, K. Degenhardt, G.H. Chen, S.K. Jin, and E. White Genes Dev. 21 2007 1367
4. P.G. Clarke Anat. Embryol. (Berl) 181 1990 195
5. R.A. Lockshin, and Z. Zakeri Oncogene 23 2004 2766
6. W. Bursch, A. Ellinger, H. Kienzl, L. Török, S. Pandey, M. Silorska, R. Walker, and R.S. Hermann Carcinogenesis 17 1996 1595
7. Y. Shao, Z. Gao, P.A. Marks, and X. Jiang Proc. Natl. Acad. Sci. U.S.A. 101 2004 18030
8. T. Kanzawa, I.M. Germano, T. Komata, H. Ito, Y. Kondo, and S. Kondo Cell Death Differ. 11 2004 448
9. H. Takeuchi, Y. Kondo, K. Fujiwara, T. Kanzawa, H. Aoki, G.B. Mills, and S. Kondo Cancer Res. 65 2005 3336
10. T. Kanzawa, Y. Kondo, H. Ito, S. Kondo, and I. Germano Cancer Res. 63 2003 2103
11. A.W. Opipari, L.J. Tan, A.E. Boitano, D.R. Sorenson, A. Aurora, and J.R. Liu Cancer Res. 64 2004 696
12. A.M. Clark, C.D. Hufford, and L.W. Robertson Lloydia 40 1977 146
13. L. Yuan, J.H. Wang, and T.M. Sun Chin. Chem. Lett. 21 2010 155
14. A. Fritsche, A.S. Elfringhoff, J. Fabian, and M. Lehr Bioorg. Med. Chem. 16 2008 3489
15. M.J. McKennon, A.I. Meyers, K. Drauz, and M. Schwarm J. Org. Chem. 58 1993 3568
16. J. Kasuga, M. Ishikawa, M. Yonehara, M. Makishima, Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. 18 2010 7164
17. M. Ishikawa, and Y. Hashimoto J. Med. Chem. 54 2011 1539
18. T. Mosmann J. Immunol. Methods 65 1983 55