SCOPUS 정보 검색 플랫폼

Tetrahedron Letters

Volumn 53, Issue 17, 2012, Pages 2171-2176

Synthesis and biological evaluation of SGLT2 inhibitors: Gem-difluoromethylenated Dapagliflozin analogs

(3) Chen, Zeng Hao a Wang, Ruo Wen a Qing, Feng Ling a,b

a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (China)

b DONGHUA UNIVERSITY (China)

Author keywords

Dapagliflozin; Diabetes; Difluoromethylene; SGLT2 inhibitor

Indexed keywords

CARBENE; DAPAGLIFLOZIN; DAPAGLIFLOZIN DERIVATIVE; FLUORODAPAGLIFLOZIN; SODIUM GLUCOSE COTRANSPORTER 2; THIODAPAGLIFLOZIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG EFFECT; DRUG SYNTHESIS; HUMAN; REACTION ANALYSIS;

EID: 84862823812 PISSN: 00404039 EISSN: 18733581 Source Type: Journal
DOI: 10.1016/j.tetlet.2012.02.062 Document Type: Article

Times cited : (24)

References (31)

1
- 0034942447
- J.D. Porte Diabetes Metab. Res. Rev. 17 2001 181 188
- (2001) Diabetes Metab. Res. Rev. , vol.17 , pp. 181-188
- Porte, J.D.¹

2
- 0034477674
- R. Kikkawa Br. J. Nutr. 84 2000 S183 S185
- (2000) Br. J. Nutr. , vol.84
- Kikkawa, R.¹

3
- 0031823401
- S.V. Edelman Med. Clin. North Am. 82 1998 665 687
- (1998) Med. Clin. North Am. , vol.82 , pp. 665-687
- Edelman, S.V.¹

4
- 77949287535
- J.J. Neumiller, J.R.J. White, and R.K. Campbell Drugs 70 2010 377 385
- (2010) Drugs , vol.70 , pp. 377-385
- Neumiller, J.J.¹ White, J.R.J.² Campbell, R.K.³

5
- 12744253796
- J.R.L. Ehrenkranz, N.G. Lewis, C. Ronald Kahn, and J. Roth Diabetes Metab. Res. Rev. 21 2005 31 38
- (2005) Diabetes Metab. Res. Rev. , vol.21 , pp. 31-38
- Ehrenkranz, J.R.L.¹ Lewis, N.G.² Ronald Kahn, C.³ Roth, J.⁴

6
- 41649087328
- W. Meng, B.A. Ellsworth, A.A. Nirschl, P.J. McCann, M. Patel, R.N. Girotra, G. Wu, P.M. Sher, E.P. Morrison, S.A. Biller, R. Zahler, P.P. Deshpande, A. Pullockaran, D.L. Hagan, N. Morgan, J.R. Taylor, M.T. Obermeier, W.G. Humphreys, A. Khanna, L. Discenza, J.G. Robertson, A. Wang, S. Han, J.R. Wetterau, E.B. Janovitz, O.P. Flint, J.M. Whaley, and W.N. Washburn J. Med. Chem. 51 2008 1145 1149
- (2008) J. Med. Chem. , vol.51 , pp. 1145-1149
- Meng, W.¹ Ellsworth, B.A.² Nirschl, A.A.³ McCann, P.J.⁴ Patel, M.⁵ Girotra, R.N.⁶ Wu, G.⁷ Sher, P.M.⁸ Morrison, E.P.⁹ Biller, S.A.¹⁰ Zahler, R.¹¹ Deshpande, P.P.¹² Pullockaran, A.¹³ Hagan, D.L.¹⁴ Morgan, N.¹⁵ Taylor, J.R.¹⁶ Obermeier, M.T.¹⁷ Humphreys, W.G.¹⁸ Khanna, A.¹⁹ Discenza, L.²⁰ more..

7
- 77956319973
- S. Nomura, S. Sakamaki, M. Hongu, E. Kawanishi, Y. Koga, T. Sakamoto, Y. Yamamoto, K. Ueta, H. Kimata, K. Nakayama, and M. Tsuda-Tsukimoto J. Med. Chem. 53 2010 6355 6360
- (2010) J. Med. Chem. , vol.53 , pp. 6355-6360
- Nomura, S.¹ Sakamaki, S.² Hongu, M.³ Kawanishi, E.⁴ Koga, Y.⁵ Sakamoto, T.⁶ Yamamoto, Y.⁷ Ueta, K.⁸ Kimata, H.⁹ Nakayama, K.¹⁰ Tsuda-Tsukimoto, M.¹¹

8
- 70350075459
- N.C. Goodwin, R. Mabon, B.A. Harrison, M.K. Shadoan, Z.Y. Almstead, Y. Xie, J. Healy, L.M. Buhring, C.M. DaCosta, J. Bardenhagen, F. Mseeh, Q. Liu, A. Nouraldeen, A.G.E. Wilson, S.D. Kimball, D.R. Powell, and D.B. Rawlins J. Med. Chem. 52 2009 6201 6204
- (2009) J. Med. Chem. , vol.52 , pp. 6201-6204
- Goodwin, N.C.¹ Mabon, R.² Harrison, B.A.³ Shadoan, M.K.⁴ Almstead, Z.Y.⁵ Xie, Y.⁶ Healy, J.⁷ Buhring, L.M.⁸ Dacosta, C.M.⁹ Bardenhagen, J.¹⁰ Mseeh, F.¹¹ Liu, Q.¹² Nouraldeen, A.¹³ Wilson, A.G.E.¹⁴ Kimball, S.D.¹⁵ Powell, D.R.¹⁶ Rawlins, D.B.¹⁷

9
- 79957603696
- T. Furuya, A.S. Kamlet, and T. Ritter Nature 473 2011 470 477
- (2011) Nature , vol.473 , pp. 470-477
- Furuya, T.¹ Kamlet, A.S.² Ritter, T.³

10
- 0014665768
- P. Goldman Science 164 1969 1123 1130
- (1969) Science , vol.164 , pp. 1123-1130
- Goldman, P.¹

11
- 0003907264
- Wiley New York
- J.T. Welch, and S. Eswarakrishnan Fluorine in Bioorganic Chemistry 1991 Wiley New York
- (1991) Fluorine in Bioorganic Chemistry
- Welch, J.T.¹ Eswarakrishnan, S.²

12
- 76649110175
- R.P. Robinson, V. Mascitti, C.M. Boustany-Kari, C.L. Carr, P.M. Foley, E. Kimoto, M.T. Leininger, A. Lowe, M.K. Klenotic, J.I. MacDonald, R.J. Maguire, V.M. Masterson, T.S. Maurer, Z. Miao, J.D. Patel, C. Préville, M.R. Reese, L. She, C.M. Steppan, B.A. Thuma, and T. Zhu Bioorg. Med. Chem. Lett. 20 2010 1569 1572
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1569-1572
- Robinson, R.P.¹ Mascitti, V.² Boustany-Kari, C.M.³ Carr, C.L.⁴ Foley, P.M.⁵ Kimoto, E.⁶ Leininger, M.T.⁷ Lowe, A.⁸ Klenotic, M.K.⁹ MacDonald, J.I.¹⁰ Maguire, R.J.¹¹ Masterson, V.M.¹² Maurer, T.S.¹³ Miao, Z.¹⁴ Patel, J.D.¹⁵ Préville, C.¹⁶ Reese, M.R.¹⁷ She, L.¹⁸ Steppan, C.M.¹⁹ Thuma, B.A.²⁰ Zhu, T.²¹ more..

13
- 0242576141
- X. Zhang, H. Xia, X. Dong, J. Jin, W.-D. Meng, and F.-L. Qing J. Org. Chem. 68 2003 9026 9033
- (2003) J. Org. Chem. , vol.68 , pp. 9026-9033
- Zhang, X.¹ Xia, H.² Dong, X.³ Jin, J.⁴ Meng, W.-D.⁵ Qing, F.-L.⁶

14
- 34247155798
- X.-H. Xu, Z.-W. You, X. Zhang, and F.-L. Qing J. Fluorine Chem. 128 2007 535 539
- (2007) J. Fluorine Chem. , vol.128 , pp. 535-539
- Xu, X.-H.¹ You, Z.-W.² Zhang, X.³ Qing, F.-L.⁴

15
- 33646728262
- R.-W. Wang, X.-L. Qiu, M. Bols, F. Ortega-Caballero, and F.-L. Qing J. Med. Chem. 49 2006 2989 2997
- (2006) J. Med. Chem. , vol.49 , pp. 2989-2997
- Wang, R.-W.¹ Qiu, X.-L.² Bols, M.³ Ortega-Caballero, F.⁴ Qing, F.-L.⁵

16
- 85077634689
- O. Mitsunobu Synthesis 1 1981 1 28
- (1981) Synthesis , vol.1 , pp. 1-28
- Mitsunobu, O.¹

17
- 0000414496
- D.L. Hughes Org. React. 42 1992 335 656
- (1992) Org. React. , vol.42 , pp. 335-656
- Hughes, D.L.¹

18
- 0033520801
- M.T. Crimmins, J.M. Pace, P.G. Nantermet, A.S. Kim-Meade, J.B. Thomas, S.H. Watterson, and A.S. Wagman J. Am. Chem. Soc. 121 1999 10249 10250
- (1999) J. Am. Chem. Soc. , vol.121 , pp. 10249-10250
- Crimmins, M.T.¹ Pace, J.M.² Nantermet, P.G.³ Kim-Meade, A.S.⁴ Thomas, J.B.⁵ Watterson, S.H.⁶ Wagman, A.S.⁷

19
- 0000102073
- K. Kadoto, M. Takeuchi, T. Taniguchi, and K. Ogasawdra Org. Lett. 3 2001 1769 1772
- (2001) Org. Lett. , vol.3 , pp. 1769-1772
- Kadoto, K.¹ Takeuchi, M.² Taniguchi, T.³ Ogasawdra, K.⁴

20
- 0037060947
- N. Brosse, A. Grandeury, and B. Jamart-Grégoire Tetrahedron Lett. 43 2002 2009 2011
- (2002) Tetrahedron Lett. , vol.43 , pp. 2009-2011
- Brosse, N.¹ Grandeury, A.² Jamart-Grégoire, B.³

21
- 67649386488
- K.C.K. Swamy, N.N.B. Kumar, E. Balaraman, and K.V.P.P. Kumar Chem. Rev. 109 2009 2551 2651
- (2009) Chem. Rev. , vol.109 , pp. 2551-2651
- Swamy, K.C.K.¹ Kumar, N.N.B.² Balaraman, E.³ Kumar, K.V.P.P.⁴

22
- 0348210598
- S. David, and S. Hanessian Tetrahedron 41 1985 643 663
- (1985) Tetrahedron , vol.41 , pp. 643-663
- David, S.¹ Hanessian, S.²

23
- 0032478584
- M.I. Barrena, M.I. Matheu, and S. Castillón J. Org. Chem. 63 1998 2184 2188
- (1998) J. Org. Chem. , vol.63 , pp. 2184-2188
- Barrena, M.I.¹ Matheu, M.I.² Castillón, S.³

24
- 59849098583
- B. Linclau, A.J. Boydell, R.S. Timofte, K.J. Brown, V. Vinader, and A.C. Weymouth-Wilson Org. Biomol. Chem. 7 2009 803 814
- (2009) Org. Biomol. Chem. , vol.7 , pp. 803-814
- Linclau, B.¹ Boydell, A.J.² Timofte, R.S.³ Brown, K.J.⁴ Vinader, V.⁵ Weymouth-Wilson, A.C.⁶

25
- 9444281976
- C. Audouard, J. Fawcett, G.A. Griffith, E. Kérourédan, A. Miah, J.M. Percy, and H. Yang Org. Lett. 6 2004 4269 4272
- (2004) Org. Lett. , vol.6 , pp. 4269-4272
- Audouard, C.¹ Fawcett, J.² Griffith, G.A.³ Kérourédan, E.⁴ Miah, A.⁵ Percy, J.M.⁶ Yang, H.⁷

26
- 0037213016
- T.M. Hansen, G.J. Florence, P. Lugo-Mas, J. Chen, J.N. Abrams, and C.J. Forsyth Tetrahedron Lett. 44 2003 57 59
- (2003) Tetrahedron Lett. , vol.44 , pp. 57-59
- Hansen, T.M.¹ Florence, G.J.² Lugo-Mas, P.³ Chen, J.⁴ Abrams, J.N.⁵ Forsyth, C.J.⁶

27
- 0001191082
- J.-M. Lancelin, P.H.A. Zollo, and P. Sinaÿ Tetrahedron Lett. 24 1983 4833 4836
- (1983) Tetrahedron Lett. , vol.24 , pp. 4833-4836
- Lancelin, J.-M.¹ Zollo, P.H.A.² Sinaÿ, P.³

28
- 7044247778
- M. Terauchi, H. Abe, A. Matsuda, and S. Shuto Org. Lett. 6 2004 3751 3754
- (2004) Org. Lett. , vol.6 , pp. 3751-3754
- Terauchi, M.¹ Abe, H.² Matsuda, A.³ Shuto, S.⁴

29
- 45449115151
- Y.H. Liu, D.L. Li, D.L. Lu, and Z.Y. Miao Chin. Chem. Lett. 19 2008 814 816
- (2008) Chin. Chem. Lett. , vol.19 , pp. 814-816
- Liu, Y.H.¹ Li, D.L.² Lu, D.L.³ Miao, Z.Y.⁴

30
- 84862815547
- Crystal data have been deposited at the Cambridge Crystallographic Data Center with reference number: CCDC 843193
- Crystal data have been deposited at the Cambridge Crystallographic Data Center with reference number: CCDC 843193.

31
- 77951143723
- H. Kakinuma, T. Oi, Y. Hashimoto-Tsuchiya, M. Arai, Y. Kawakita, Y. Fukasawa, I. Iida, N. Hagima, H. Takeuchi, Y. Chino, J. Asami, L. Okumura-Kitajima, F. Io, D. Yamamoto, N. Miyata, T. Takahashi, S. Uchida, and K. Yamamoto J. Med. Chem. 53 2010 3247 3261
- (2010) J. Med. Chem. , vol.53 , pp. 3247-3261
- Kakinuma, H.¹ Oi, T.² Hashimoto-Tsuchiya, Y.³ Arai, M.⁴ Kawakita, Y.⁵ Fukasawa, Y.⁶ Iida, I.⁷ Hagima, N.⁸ Takeuchi, H.⁹ Chino, Y.¹⁰ Asami, J.¹¹ Okumura-Kitajima, L.¹² Io, F.¹³ Yamamoto, D.¹⁴ Miyata, N.¹⁵ Takahashi, T.¹⁶ Uchida, S.¹⁷ Yamamoto, K.¹⁸

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.