Structure-activity relationship studies of 1-(4-chloro-2,5-dimethoxyphenyl) -3-(3-propoxypropyl)thiourea, a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type-1

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 447-467

  Weitman, Michal ^a   Lerman, Keti ^a   Nudelman, Abraham ^a   Major, Dan Thomas ^a   Hizi, Amnon ^b   Herschhorn, Alon ^b,c  

^a BAR ILAN UNIVERSITY   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

HIV 1; Reverse transcriptase; Thioureas

Indexed keywords

1 (2,5 DIMETHOXY 4 NITROPHENYL) 3 (3 PROPOXYPROPYL)THIOUREA; 1 (4 CHLORO 2,5 DIETHOXYPHENYL) 3 (3 PROPOXYPROPYL)THIOUREA; 1 (4 CHLORO 2,5 DIETHOXYPHENYL) 3 HEXYLTHIOUREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 (2 PROPOXYETHYL)THIOUREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 (3 (PROPYLAMINO)PROPYL)THIOUREA HYDROCHLORIDE; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 (3 (PROPYLSULFINYL)THIOUREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 (3 (PROPYLTHIO)PROPYL)THIOUREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 (3 (PROPYLTHIO)PROPYL)UREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 (3 ETHOXYPROPYL)THIOUREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 (3 HYDROXYPROPYL)THIOUREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 (3 METHOXYPROPYL)THIOUREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 (3 PROPOXYPROPYL)THIOUREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 (3 PROPOXYPROPYL)UREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 HEPTYLTHIOUREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 HEPTYLUREA; 1 (4 CHLORO 2,5 DIMETHOXYPHENYL) 3 HEXYLTHIOUREA; 1 (4 CHLORO 2,5 DIPROPOXYPHENYL) 3 (3 PROPOXYPROPYL)THIOUREA; 11 (4 CHLORO 2,5 DIETHOXYPHENYL) 3 HEPTYLTHIOUREA; 3 (3 (4 CHLORO 2,5 DIMETHOXYPHENYL)THIOUREIDO)PROPYLACETATE; 3 (3 (4 CHLORO 2,5 DIMETHOXYPHENYL)THIOUREIDO)PROPYLBUTYRATE; 3 (3 (4 CHLORO 2,5 DIMETHOXYPHENYL)THIOUREIDO)PROPYLPROPIONATE; 4 (AMINO N (4 CHLORO 2,5 DIMETHOXYPHENYL)METHANETHIOAMINO)BUTANOATE; ANTIVIRUS AGENT; BUTYL 3 (AMINO N (4 CHLORO 2,5 DIMETHOXYPHENYL)METHANETHIOAMI)PROPANOATE; BUTYRIC N (3 (BUTYRYL OXY)PROPYL) N (4 CHLORO 2,5 DIMETHOXYPHENYL)CARBAMIMIDIC THIOANHYDRIDE; METHYL 3 (AMINO N (4 CHLORO 2,5 DIMETHOXYPHENYL)METHANETHIOAMI)PROPANOATE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROPYL 3 (AMINO N (4 CHLORO 2,5 DIMETHOXYPHENYL)METHANETHIOAMI)PROPANOATE; TERT BUTYL 3 (3 (4 CHLORO 2,5 DIMETHOXYPHENYL)THIOUREIDO)PROPYLPROPYLCARBAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG POTENCY; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS CELL INTERACTION; VIRUS INFECTIVITY;

HIV REVERSE TRANSCRIPTASE; HIV-1; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

EID: 79151473381     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.003     Document Type: Article

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