-
2
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
DOI 10.1126/science.1134108
-
M. Neumann, D.M. Sampathu, L.K. Kwong, A.C. Truax, M.C. Micsenyi, and T.T. Chou Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science 314 2006 130 133 (Pubitemid 44547757)
-
(2006)
Science
, vol.314
, Issue.5796
, pp. 130-133
-
-
Neumann, M.1
Sampathu, D.M.2
Kwong, L.K.3
Truax, A.C.4
Micsenyi, M.C.5
Chou, T.T.6
Bruce, J.7
Schuck, T.8
Grossman, M.9
Clark, C.M.10
McCluskey, L.F.11
Miller, B.L.12
Masliah, E.13
Mackenzie, I.R.14
Feldman, H.15
Feiden, W.16
Kretzschmar, H.A.17
Trojanowski, J.Q.18
Lee, V.M.-Y.19
-
3
-
-
33750716074
-
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
DOI 10.1016/j.bbrc.2006.10.093, PII S0006291X06023187
-
T. Arai, M. Hasegawa, H. Akiyama, K. Ikeda, T. Nonaka, and H. Mori TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Biochem Biophys Res Commun 351 2006 602 611 (Pubitemid 44708852)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.351
, Issue.3
, pp. 602-611
-
-
Arai, T.1
Hasegawa, M.2
Akiyama, H.3
Ikeda, K.4
Nonaka, T.5
Mori, H.6
Mann, D.7
Tsuchiya, K.8
Yoshida, M.9
Hashizume, Y.10
Oda, T.11
-
4
-
-
34447103093
-
TDP-43 proteinopathy: The neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease
-
DOI 10.1007/s00401-007-0226-5
-
L.K. Kwong, M. Neumann, D.M. Sampathu, V.M.-Y. Lee, and J.Q. Trojanowski TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease Acta Neuropathol 114 2007 63 70 (Pubitemid 47029061)
-
(2007)
Acta Neuropathologica
, vol.114
, Issue.1
, pp. 63-70
-
-
Kwong, L.K.1
Neumann, M.2
Sampathu, D.M.3
Lee, V.M.-Y.4
Trojanowski, J.Q.5
-
5
-
-
33749668518
-
Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: Classification and relation to clinical phenotype
-
DOI 10.1007/s00401-006-0138-9
-
I.R.A. Mackenzie, A. Baborie, S. Pickering-Brown, D.D. Plessis, E. Jaros, and R.H. Perry Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype Acta Neuropathol 112 2006 539 549 (Pubitemid 44550678)
-
(2006)
Acta Neuropathologica
, vol.112
, Issue.5
, pp. 539-549
-
-
Mackenzie, I.R.A.1
Baborie, A.2
Pickering-Brown, S.3
Plessis, D.D.4
Jaros, E.5
Perry, R.H.6
Neary, D.7
Snowden, J.S.8
Mann, D.M.A.9
-
6
-
-
47949096734
-
Sporadic amyotrophic lateral sclerosis: Two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions
-
Y. Nishihira, C.-F. Tan, O. Onodera, Y. Toyoshima, M. Yamada, and T. Morita Sporadic amyotrophic lateral sclerosis: Two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions Acta Neuropathol 116 2008 169 182
-
(2008)
Acta Neuropathol
, vol.116
, pp. 169-182
-
-
Nishihira, Y.1
Tan, C.-F.2
Onodera, O.3
Toyoshima, Y.4
Yamada, M.5
Morita, T.6
-
7
-
-
47949110973
-
White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease: TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin
-
M. Hiji, T. Takahashi, H. Fukuba, H. Yamashita, T. Kohriyama, and M. Matsumoto White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease: TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin Acta Neuropathol 116 2008 183 191
-
(2008)
Acta Neuropathol
, vol.116
, pp. 183-191
-
-
Hiji, M.1
Takahashi, T.2
Fukuba, H.3
Yamashita, H.4
Kohriyama, T.5
Matsumoto, M.6
-
8
-
-
77955395385
-
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U
-
K.-J. Tsai, C.-H. Yang, Y.-H. Fang, K.-H. Cho, W.-L. Chien, and W.-T. Wang Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U J Exp Med 207 2010 1661 1673
-
(2010)
J Exp Med
, vol.207
, pp. 1661-1673
-
-
Tsai, K.-J.1
Yang, C.-H.2
Fang, Y.-H.3
Cho, K.-H.4
Chien, W.-L.5
Wang, W.-T.6
-
9
-
-
77956199371
-
Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice
-
Y.F. Xu, T.F. Gendron, Y.J. Zhang, W.L. Lin, S. D'Alton, and H. Sheng Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice J Neurosci 30 2010 10851 10859
-
(2010)
J Neurosci
, vol.30
, pp. 10851-10859
-
-
Xu, Y.F.1
Gendron, T.F.2
Zhang, Y.J.3
Lin, W.L.4
D'Alton, S.5
Sheng, H.6
-
10
-
-
77649269011
-
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
-
H. Wils, G. Kleinberger, J. Janssens, S. Pereson, G. Joris, and I. Cuijt TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration PNAS 107 2010 3858 3863
-
(2010)
PNAS
, vol.107
, pp. 3858-3863
-
-
Wils, H.1
Kleinberger, G.2
Janssens, J.3
Pereson, S.4
Joris, G.5
Cuijt, I.6
-
11
-
-
73249152831
-
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal degeneration
-
I. Wegorzewska, S. Bell, N.J. Cairns, T.M. Miller, and R.H. Baloh TDP-43 mutant transgenic mice develop features of ALS and frontotemporal degeneration PNAS 106 2009 18809 18814
-
(2009)
PNAS
, vol.106
, pp. 18809-18814
-
-
Wegorzewska, I.1
Bell, S.2
Cairns, N.J.3
Miller, T.M.4
Baloh, R.H.5
-
12
-
-
34848921202
-
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43
-
DOI 10.1523/JNEUROSCI.3421-07.2007
-
Y.-J. Zhang, Xu. Y-f, C.A. Dickey, E. Buratti, F. Baralle, and R. Bailey Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43 J Neurosci 27 2007 10530 10534 (Pubitemid 47501990)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.39
, pp. 10530-10534
-
-
Zhang, Y.-J.1
Xu, Y.-F.2
Dickey, C.A.3
Buratti, E.4
Baralle, F.5
Bailey, R.6
Pickering-Brown, S.7
Dickson, D.8
Petrucelli, L.9
-
13
-
-
44049097065
-
A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity
-
DOI 10.1073/pnas.0802082105
-
B.S. Johnson, J.M. McCaffery, S. Lindquist, and A.D. Gitler A yeast TDP-43 proteinopathy model: exploring the molecular determinants of TDP-43 aggregation and cellular toxicity Proc Natl Acad Sci U S A 105 2008 6439 6444 (Pubitemid 351758364)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.17
, pp. 6439-6444
-
-
Johnson, B.S.1
McCaffery, J.M.2
Lindquist, S.3
Gitler, A.D.4
-
14
-
-
67650113333
-
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
-
T. Nonaka, F. Kametani, T. Arai, H. Akiyama, and M. Hasegawa Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43 Hum Mol Genet 18 2009 3353 3364
-
(2009)
Hum Mol Genet
, vol.18
, pp. 3353-3364
-
-
Nonaka, T.1
Kametani, F.2
Arai, T.3
Akiyama, H.4
Hasegawa, M.5
-
15
-
-
37349008891
-
Progranulin: Normal function and role in neurodegeneration
-
DOI 10.1111/j.1471-4159.2007.04968.x
-
J.L. Eriksen, and I.R.A. Mackenzie Progranulin: normal function and role in neurodegeneration J Neurochem 104 2008 287 297 (Pubitemid 350293866)
-
(2008)
Journal of Neurochemistry
, vol.104
, Issue.2
, pp. 287-297
-
-
Eriksen, J.L.1
Mackenzie, I.R.A.2
-
16
-
-
38349173569
-
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion
-
S.S. Shankaran, A. Capell, A.T. Hruscha, K. Fellerer, M. Neumann, and B. Schmid Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion J Biol Chem 283 2008 1744 1753
-
(2008)
J Biol Chem
, vol.283
, pp. 1744-1753
-
-
Shankaran, S.S.1
Capell, A.2
Hruscha, A.T.3
Fellerer, K.4
Neumann, M.5
Schmid, B.6
-
17
-
-
79551523377
-
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
-
L.M. Igaz, L.K. Kwong, E.B. Lee, A. Chen-Plotkin, E. Swanson, and T. Unger Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice J Clin Invest 121 2011 726 738
-
(2011)
J Clin Invest
, vol.121
, pp. 726-738
-
-
Igaz, L.M.1
Kwong, L.K.2
Lee, E.B.3
Chen-Plotkin, A.4
Swanson, E.5
Unger, T.6
-
18
-
-
77956155794
-
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43
-
R.A. Fuentealba, M. Udan, S. Bell, I. Wegorzewska, J. Shao, and M.I. Diamond Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43 J Biol Chem 285 2010 26304 26314
-
(2010)
J Biol Chem
, vol.285
, pp. 26304-26314
-
-
Fuentealba, R.A.1
Udan, M.2
Bell, S.3
Wegorzewska, I.4
Shao, J.5
Diamond, M.I.6
-
19
-
-
84555205690
-
Ammonia-induced brain swelling and neurotoxicity in an organotypic slice model
-
A. Back, K.Y. Tupper, T. Bai, P. Chiranand, F.D. Goldenberg, and J.I. Frank Ammonia-induced brain swelling and neurotoxicity in an organotypic slice model Neurol Res 33 2011 1100 1108
-
(2011)
Neurol Res
, vol.33
, pp. 1100-1108
-
-
Back, A.1
Tupper, K.Y.2
Bai, T.3
Chiranand, P.4
Goldenberg, F.D.5
Frank, J.I.6
-
20
-
-
34249712890
-
TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations
-
DOI 10.1093/brain/awm024
-
H. Seelaar, J. Schelhaas, A. Azmani, B. Kusters, S. Rosso, and D. Majoor-Krakauer TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without progranulin mutations Brain 130 2007 1375 1385 (Pubitemid 47355944)
-
(2007)
Brain
, vol.130
, Issue.5
, pp. 1375-1385
-
-
Seelaar, H.1
Jurgen Schelhaas, H.2
Azmani, A.3
Kusters, B.4
Rosso, S.5
Majoor-Krakauer, D.6
De Rijik, M.C.7
Rizzu, P.8
Ten Brummelhuis, M.9
Van Doorn, P.A.10
Kamphorst, W.11
Willemsen, R.12
Van Swieten, J.C.13
-
21
-
-
0025729489
-
Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity
-
P.N. Leigh, H. Whitwell, O. Garofalo, J. Buller, M. Swash, and J.E. Martin Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity Brain 114 1991 775 788
-
(1991)
Brain
, vol.114
, pp. 775-788
-
-
Leigh, P.N.1
Whitwell, H.2
Garofalo, O.3
Buller, J.4
Swash, M.5
Martin, J.E.6
-
22
-
-
73649148708
-
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43
-
Y. Nishimoto, D. Ito, T. Yagi, Y. Nihei, Y. Tsunoda, and N. Suzuki Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43 J Biol Chem 285 2010 608 619
-
(2010)
J Biol Chem
, vol.285
, pp. 608-619
-
-
Nishimoto, Y.1
Ito, D.2
Yagi, T.3
Nihei, Y.4
Tsunoda, Y.5
Suzuki, N.6
-
23
-
-
78651299905
-
Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures
-
G. Kleinberger, H. Wils, P. Ponsaerts, G. Joris, J.-P. Timmermans, and C. Van Broeckhoven Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures J Neurochem 115 2010 735 747
-
(2010)
J Neurochem
, vol.115
, pp. 735-747
-
-
Kleinberger, G.1
Wils, H.2
Ponsaerts, P.3
Joris, G.4
Timmermans, J.-P.5
Van Broeckhoven, C.6
-
24
-
-
79953855830
-
TDP-43-induced death is associated with altered regulation of Bim and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage
-
H. Suzuki, K. Lee, and M. Matsuoka TDP-43-induced death is associated with altered regulation of Bim and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage J Biol Chem 286 2011 13171 13183
-
(2011)
J Biol Chem
, vol.286
, pp. 13171-13183
-
-
Suzuki, H.1
Lee, K.2
Matsuoka, M.3
-
25
-
-
79251648286
-
Progranulin deficiency leades to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures
-
A. Guo, L. Tapia, S.X. Bamji, M.S. Cynader, and W. Jia Progranulin deficiency leades to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures Brain Res 1366 2010 1 8
-
(2010)
Brain Res
, vol.1366
, pp. 1-8
-
-
Guo, A.1
Tapia, L.2
Bamji, S.X.3
Cynader, M.S.4
Jia, W.5
-
26
-
-
34247123666
-
TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions
-
DOI 10.1097/01.jnen.0000248554.45456.58, PII 0000507220070300000002
-
M. Neumann, L.K. Kwong, A.C. Truax, B. Vanmassenhove, H.A. Kretzschmar, and V.M.V. Deerlin TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions J Neuropathol Exp Neurol 66 2007 177 183 (Pubitemid 46673273)
-
(2007)
Journal of Neuropathology and Experimental Neurology
, vol.66
, Issue.3
, pp. 177-183
-
-
Neumann, M.1
Kwong, L.K.2
Truax, A.C.3
Vanmassenhove, B.4
Kretzschmar, H.A.5
Van Deerlin, V.M.6
Clark, C.M.7
Grossman, M.8
Miller, B.L.9
Trojanowski, J.Q.10
Lee, V.M.-Y.11
-
27
-
-
47949099336
-
Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia
-
F. Mori, K. Tanji, H.-X. Zhang, Y. Nishihira, C.-F. Tan, and H. Takahashi Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia Acta Neuropathol 116 2008 193 203
-
(2008)
Acta Neuropathol
, vol.116
, pp. 193-203
-
-
Mori, F.1
Tanji, K.2
Zhang, H.-X.3
Nishihira, Y.4
Tan, C.-F.5
Takahashi, H.6
|