Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma

Histopathology

Volumn 60, Issue 5, 2012, Pages 793-803

  Huang, Congfa ^a   Sun, Zhijun ^a   Sun, Yan ^a   Chen, Xinming ^a   Zhu, Xiaojie ^a   Fan, Chengchao ^a   Liu, Bing ^a   Zhao, Yifang ^a   Zhang, Wenfeng ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

CD147; CypA; Hypoxia; Metastasis; Prognosis; Tongue squamous cell carcinoma

Indexed keywords

CD147 ANTIGEN; CYCLOPHILIN A; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN A; VASCULOTROPIN C;

ADULT; ANGIOGENESIS; ARTICLE; BONE METASTASIS; CANCER PATIENT; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOUTH MUCOSA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TONGUE CARCINOMA; TONGUE SQUAMOUS CELL CARCINOMA;

ANTIGENS, CD147; CARCINOMA, SQUAMOUS CELL; CHINA; CYCLOPHILIN A; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; LIGANDS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; SURVIVAL RATE; TONGUE NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84862818295     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.04130.x     Document Type: Article

References (37)

1. Okada Y. Relationships of cervical lymph node metastasis to histopathological malignancy grade, tumor angiogenesis, and lymphatic invasion in tongue cancer. Odontology 2010; 98; 153-159.
2. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100; 57-70.
3. Janssen HL, Haustermans KM, Balm AJ, Begg AC. Hypoxia in head and neck cancer: how much, how important? Head Neck 2005; 27; 622-638.
4. Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL. Expression of hypoxia-inducible factor 1a in brain tumors: association with angiogenesis, invasion, and progression. Cancer 2000; 88; 2606-2018.
5. Zhang J, Peng B, Chen X. Expressions of nuclear factor kappaB, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: correlations with the angiogenesis and clinical outcome. Clin. Cancer Res. 2005; 11; 7334-7343.
6. Smith BD, Haffty BG, Sasaki CT. Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma. J. Clin. Oncol. 2000; 18; 2046-2052.
7. Aebersold DM, Beer KT, Laissue J et al. Intratumoral microvessel density predicts local treatment failure of radically irradiated squamous cell cancer of the oropharynx. Int. J. Radiat. Oncol. Biol. Phys. 2000; 48; 17-25.
8. Benke EM, Ji Y, Patel V, Wang H, Miyazaki H, Yeudall WA. VEGF-C contributes to head and neck squamous cell carcinoma growth and motility. Oral Oncol. 2010; 46; e19-e24.
9. Choi KJ, Piao YJ, Lim MJ et al. Overexpressed cyclophilin A in cancer cells renders resistance to hypoxia- and cisplatin-induced cell death. Cancer Res. 2007; 67; 3654-3662.
10. Colgan J, Asmal M, Neagu M et al. Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk. Immunity 2004; 21; 189-201.
11. Arora K, Gwinn WM, Bower MA et al. Extracellular cyclophilins contribute to the regulation of inflammatory responses. J. Immunol. 2005; 175; 517-522.
12. Jin ZG, Melaragno MG, Liao DF et al. Cyclophilin A is a secreted growth factor induced by oxidative stress. Circ. Res. 2000; 87; 789-796.
13. Kim SH, Lessner SM, Sakurai Y, Galis ZS. Cyclophilin A as a novel biphasic mediator of endothelial activation and dysfunction. Am. J. Pathol. 2004; 164; 1567-1574.
14. Damsker JM, Bukrinsky MI, Constant SL. Preferential chemotaxis of activated human CD4 T cells by extracellular cyclophilin A. J. Leukoc. Biol. 2007; 82; 613-618.
15. Zheng HC, Takahashi H, Murai Y et al. Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosis. Br. J. Cancer 2006; 95; 1371-1378.
16. Li M, Zhai Q, Bharadwaj U et al. Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147. Cancer 2006; 106; 2284-2294.
17. Sobin LH, Wittekind C eds. International Union Against Cancer (UICC): TNM classification of malignant tumors, 6th edn. New York: Wiley, 2002.
18. Barnes L, Eveson JW, Reichart P, Sidransky D. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press, 2005; 168-175.
19. Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 2000; 60; 4693-4696.
20. Theodoropoulos VE, Lazaris AC, Sofras F et al. Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur. Urol. 2004; 46; 200-208.
21. Li Z, Zhao X, Bai S et al. Proteomics identification of cyclophilin a as a potential prognostic factor and therapeutic target in endometrial carcinoma. Mol. Cell Proteomics 2008; 7; 1810-1823.
22. Miyahara M, Tanuma J, Sugihara K, Semba I. Tumor lymphangiogenesis correlates with lymph node metastasis and clinicopathologic parameters in oral squamous cell carcinoma. Cancer 2007; 110; 1287-1294.
23. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis correlation in invasive breast carcinoma. N. Engl. J. Med. 1991; 324; 1.
24. Forsythe JA, Jiang BH, Iyer NV et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 1996; 16; 4604-4613.
25. Ravi R, Mookerjee B, Bhujwalla ZM et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1 alpha. Genes Dev. 2000; 14; 34-44.
26. Joukov V, Pajusola K, Kaipainen A et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 1996; 15; 290-298.
27. Katsuta M, Miyashita M, Makino H et al. Correlation of hypoxia inducible factor-1a with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer. Exp. Mol. Pathol. 2005; 78; 123-130.
28. Fujii T, Otsuki T, Moriya T et al. Effect of hypoxia on human seminoma cells. Int. J. Oncol. 2002; 20; 955-962.
29. Nakaya H, Kawashiri S, Tanaka A et al. Influences of angiogenesis and lymphangiogenesis on cancerous invasion in experimentally induced tongue carcinoma. J. Oral Pathol. Med. 2005; 34; 87-92.
30. Ohta Y, Shridhar V, Bright RK et al. VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours. Br. J. Cancer 1999; 81; 54-61.
31. Chen J, He QY, Yuen AP, Chiu JF. Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis. Proteomics 2004; 4; 2465-2475.
32. Vigneswaran N, Beckers S, Waigel S et al. Increased EMMPRIN (CD147) expression during oral carcinogenesis. Exp. Mol. Pathol. 2006; 80; 147-159.
33. Iacono KT, Brown AL, Greene MI, Saouaf SJ. CD147 immunoglobulin superfamily receptor function and role in pathology. Exp. Mol. Pathol. 2007; 83; 283-295.
34. Kuwai T, Kitadai Y, Tanaka S et al. Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int. J. Cancer 2003; 105; 176-181.
35. Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI, Tumor Angiogenesis Research Group. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 2002; 95; 1055-1063.
36. Howard BA, Zheng Z, Campa MJ et al. Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer. Lung Cancer 2004; 46; 313-323.
37. Han ZD, Bi XC, Qin WJ et al. CD147 expression indicates unfavourable prognosis in prostate cancer. Pathol. Oncol. Res. 2009; 15; 369-374.