Human cord blood stem cells and the journey to a cure for type 1 diabetes

Autoimmunity Reviews

Volumn 10, Issue 2, 2010, Pages 103-107

  Zhao, Yong ^a   Mazzone, Theodore ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cord blood stem cell; Immune modulation; Islet cell regeneration; Regulatory T cell; TGF 1; Type 1 diabetes

Indexed keywords

INSULIN; TRANSFORMING GROWTH FACTOR BETA1;

AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CORD BLOOD STEM CELL TRANSPLANTATION; DIABETES MELLITUS; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; PANCREAS ISLET BETA CELL; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; REGULATORY T LYMPHOCYTE; REVIEW; UMBILICAL CORD BLOOD;

CORD BLOOD STEM CELL TRANSPLANTATION; DIABETES MELLITUS, TYPE 1; FETAL BLOOD; HUMANS; ISLETS OF LANGERHANS; REGENERATIVE MEDICINE; STEM CELLS;

EID: 78650417032     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2010.08.011     Document Type: Review

References (40)

1. Gluckman E. History of cord blood transplantation. Bone Marrow Transplant 2009, 44:621-626.
2. Robertson R.P. Islet transplantation a decade later and strategies for filling a half-full glass. Diabetes 2010, 59:1285-1291.
3. Bluestone J.A., Herold K., Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010, 464:1293-1300.
4. Abdi R., Fiorina P., Adra C.N., Atkinson M., Sayegh M.H. Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes. Diabetes 2008, 57:1759-1767.
5. Aguayo-Mazzucato C., Bonner-Weir S. Stem cell therapy for type 1 diabetes mellitus. Nat Rev Endocrinol 2010, 6:139-148.
6. Zhao Y., Glesne D., Huberman E. A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proc Nat Acad Sci USA 2003, 100:2426-2431.
7. Zhao Y., Lin B., Dingeldein M., Guo C., Hwang D., Holterman M.J. New type of human blood stem cell: a double-edged sword for the treatment of type 1 diabetes. Transl Res 2010, 155:211-216.
8. Zhou Q., Brown J., Kanarek A., Rajagopal J., Melton D.A. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008, 455:627-632.
9. Petrovsky N. Immunomodulation with microbial vaccines to prevent type 1 diabetes mellitus. Nat Rev Endocrinol 2010, 6:131-138.
10. Zhao Y., Lin B., Darflinger R., Zhang Y., Holterman M.J., Skidgel R.A. Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice. PLoS ONE 2009, 4:e4226.
11. Zhao Y., Huang Z., Qi M., Lazzarini P., Mazzone T. Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell. Immunol Lett 2007, 108:78-87.
12. Zhao Y., Wang H., Mazzone T. Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Exp Cell Res 2006, 312:2454-2464.
13. Zhao Y., Mazzone T. Human umbilical cord blood-derived f-macrophages retain pluripotentiality after thrombopoietin expansion. Exp Cell Res 2005, 310:311-318.
14. Francese R., Fiorina P. Immunological and regenerative properties of cord blood stem cells. Clin Immunol 2010, 136:309-322.
15. Uccelli A., Moretta L., Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008, 8:726-736.
16. Bluestone J.A., Tang Q., Sedwick C.E. T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol 2008, 28:677-684.
17. Alonso N., Soldevila B., Sanmarti A., Pujol-Borrell R., Martinez-Caceres E. Regulatory T cells in diabetes and gastritis. Autoimmun Rev 2009, 8:659-662.
18. Haller M.J., Viener H.L., Wasserfall C., Brusko T., Atkinson M.A., Schatz D.A. Autologous umbilical cord blood infusion for type 1 diabetes. Exp Hematol 2008, 36:710-715.
19. Virtanen I., Banerjee M., Palgi J., Korsgren O., Lukinius A., Thornell L.E., et al. Blood vessels of human islets of Langerhans are surrounded by a double basement membrane. Diabetologia 2008, 51:1181-1191.
20. Kragl M., Lammert E. Basement membrane in pancreatic islet function. Adv Exp Med Biol 2010, 654:217-234.
21. Irving-Rodgers H.F., Ziolkowski A.F., Parish C.R., Sado Y., Ninomiya Y., Simeonovic C.J., et al. Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis. Diabetologia 2008, 51:1680-1688.
22. Sanvito F., Herrera P.L., Huarte J., Nichols A., Montesano R., Orci L., et al. TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro. Development 1994, 120:3451-3462.
23. Miralles F., Battelino T., Czernichow P., Scharfmann R. TGF-beta plays a key role in morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2. J Cell Biol 1998, 143:827-836.
24. Schmierer B., Hill C.S. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 2007, 8:970-982.
25. Brissova M., Shostak A., Shiota M., Wiebe P.O., Poffenberger G., Kantz J., et al. Pancreatic islet production of vascular endothelial growth factor-a is essential for islet vascularization, revascularization, and function. Diabetes 2006, 55:2974-2985.
26. Brissova M., Powers A.C. Revascularization of transplanted islets: can it be improved?. Diabetes 2008, 57:2269-2271.
27. Au P., Daheron L.M., Duda D.G., Cohen K.S., Tyrrell J.A., Lanning R.M., et al. Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood 2008, 111:1302-1305.
28. Seta N., Kuwana M. Derivation of multipotent progenitors from human circulating CD14+ monocytes. Exp Hematol 2010, 38:557-563.
29. Park K.S., Kim Y.S., Kim J.H., Choi B.K., Kim S.H., Oh S.H., et al. Influence of human allogenic bone marrow and cord blood-derived mesenchymal stem cell secreting trophic factors on ATP (adenosine-5'-triphosphate)/ADP (adenosine-5'-diphosphate) ratio and insulin secretory function of isolated human islets from cadaveric donor. Transplant Proc 2009, 41:3813-3818.
30. Parekh V.S., Joglekar M.V., Hardikar A.A. Differentiation of human umbilical cord blood-derived mononuclear cells to endocrine pancreatic lineage. Differentiation 2009, 78:232-240.
31. Sun B., Roh K.H., Lee S.R., Lee Y.S., Kang K.S. Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure. Biochem Biophys Res Commun 2007, 354:919-923.
32. Gao F., Wu D.Q., Hu Y.H., Jin G.X., Li G.D., Sun T.W., et al. In vitro cultivation of islet-like cell clusters from human umbilical cord blood-derived mesenchymal stem cells. Transl Res 2008, 151:293-302.
33. Lechner A., Yang Y.G., Blacken R.A., Wang L., Nolan A.L., Habener J.F. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 2004, 53:616-623.
34. Denner L., Bodenburg Y., Zhao J.G., Howe M., Cappo J., Tilton R.G., et al. Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin. Cell Prolif 2007, 40:367-380.
35. Giorgetti A., Montserrat N., Rodriguez-Piza I., Azqueta C., Veiga A., Izpisua Belmonte J.C. Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2. Nat Protoc 2010, 5:811-820.
36. Maehr R., Chen S., Snitow M., Ludwig T., Yagasaki L., Goland R., et al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Nat Acad Sci USA 2009, 106:15768-15773.
37. Todd J.A. Stem cells and a cure for type 1 diabetes?. Proc Nat Acad Sci USA 2009, 106:15523-15524.
38. Gluckman E., Broxmeyer H.A., Auerbach A.D., Friedman H.S., Douglas G.W., Devergie A., et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 1989, 321:1174-1178.
39. Haller M.J., Wasserfall C.H., McGrail K.M., Cintron M., Brusko T.M., Wingard J.R., et al. Autologous umbilical cord blood transfusion in very young children with type 1 diabetes. Diabetes Care 2009, 32:2041-2046.
40. Wall D.A., Chan K.W. Selection of cord blood unit(s) for transplantation. Bone Marrow Transplant 2008, 42:1-7.