The Evolution of HLA-B *3501 Binding Affinity to Variable Immunodominant NP 418-426 Peptides from 1918 to 2009 Pandemic Influenza A Virus: A Molecular Dynamics Simulation and Free Energy Calculation Study

Chemical Biology and Drug Design

Volumn 79, Issue 6, 2012, Pages 1025-1032

  Guo, Jingjing ^a   Wang, Xiaoting ^a   Sun, Huijun ^a   Liu, Huanxiang ^b   Shen, Yulin ^c   Yao, Xiaojun ^a  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU UNIVERSITY   (China)

^c Gansu Computing Center   (China)

Author keywords

2009 influenza A virus; 3501; HLA B; Molecular dynamics simulation; NP 418 426; PMHC I

Indexed keywords

EPITOPE; HLA B 3501 PROTEIN; HLA B ANTIGEN; NP 418 426 ANTIGENIC PEPTIDE; PEPTIDE; UNCLASSIFIED DRUG;

2009 H1N1 INFLUENZA; ARTICLE; BINDING AFFINITY; CELLULAR IMMUNITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SPANISH INFLUENZA;

AMINO ACID SEQUENCE; BINDING SITES; EVOLUTION, MOLECULAR; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HLA-B35 ANTIGEN; HUMANS; HYDROGEN BONDING; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MOLECULAR DYNAMICS SIMULATION; MUTATION; NUCLEOPROTEINS; PANDEMICS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; T-LYMPHOCYTES, CYTOTOXIC; THERMODYNAMICS;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

EID: 84862818017     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2012.01357.x     Document Type: Article

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