A technical mixture of 2,2′,4,4′-tetrabromo diphenyl ether (BDE47) and brominated furans triggers aryl hydrocarbon receptor (AhR) mediated gene expression and toxicity

Chemosphere

Volumn 73, Issue 2, 2008, Pages 209-215

  Wahl, M ^a   Lahni, B ^a   Guenther, R ^a   Kuch, B ^b   Yang, L ^a   Straehle, U ^a   Strack, S ^a   Weiss, C ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF STUTTGART   (Germany)

Author keywords

2,2 ,4,4 tetrabromo diphenyl ether (BDE47); 2,3,7,8 tetrabromodibenzofuran (TBDF); Aryl hydrocarbon receptor (AhR); Flame retardants; Microarray analysis

Indexed keywords

ARSENIC COMPOUNDS; BIOACTIVITY; CHLORINE COMPOUNDS; ETHERS; GENE EXPRESSION; HYDROCARBON REFINING; HYDROCARBONS; MIXTURES; ORGANIC COMPOUNDS; POLYACRYLATES; SEDIMENTATION; TOXICITY; TRACE ANALYSIS;

2,3,7,8-TETRABROMODIBENZOFURAN (TBDF); ARYL HYDROCARBON RECEPTOR; ARYL HYDROCARBON RECEPTOR (AHR); CELLULAR HOMEOSTASIS; CHEMICAL-; CYTOCHROME P-450; DIOXIN-LIKE COMPOUNDS; DIPHENYL ETHERS; ENDOCRINE SYSTEMS; FLAME RETARDANTS; HEPATOMA CELLS; HUMAN BLOOD SAMPLES; HUMAN HEPATOMA CELLS; LOW GRADE; MICROARRAY ANALYSIS; MULTIPLE LEVELS; POLY-BROMINATED DIPHENYL ETHERS; RAT HEPATOCYTES; STRUCTURAL SIMILARITIES; ZEBRAFISH EMBRYOS;

ACTIVATION ANALYSIS;

2,2',4,4' TETRABROMODIPHENYL ETHER; 2,3,7,8 TETRABROMODIBENZOFURAN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 2B; CYTOCHROME P450 3A; DIOXIN; FURAN DERIVATIVE; POLYBROMINATED DIPHENYL ETHER; UNCLASSIFIED DRUG;

ARRAY; CHEMICAL ANALYSIS; GENE EXPRESSION; GENOTOXICITY; HOMEOSTASIS; HYDROCARBON; PBDE; TCDD;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENZYME INDUCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; MEASUREMENT; MICROARRAY ANALYSIS; NONHUMAN; POLLUTANT; POLYMERASE CHAIN REACTION; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ZEBRA FISH;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 CYP3A; EMBRYO, NONMAMMALIAN; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYBROMINATED BIPHENYLS; RATS; RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ZEBRAFISH;

DANIO RERIO; RATTUS;

EID: 50049095883     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2008.05.025     Document Type: Article

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