Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 6, 2012, Pages 2180-2188

  Davis, Gary C ^a,b   Kong, Yali ^b   Paige, Mikell ^b   Li, Zhang ^b   Merrick, Ellen C ^c   Hansen, Todd ^a,b   Suy, Simeng ^b   Wang, Kan ^b   Dakshanamurthy, Sivanesan ^b   Cordova, Antoinette ^b   McManus, Owen B ^e   Williams, Brande S ^d   Chruszcz, Maksymilian ^c   Minor, Wladek ^c   Patel, Manoj K ^c   Brown, Milton L ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Frater Seebach; Ion channel blocker; Prostate cancer

Indexed keywords

2 (3 CHLOROPHENYL) 2 HYDROXY NONANOIC ACID AMIDE; 2 (3 CHLOROPHENYL) 2 HYDROXYNONANAMIDE; 2 (3 CHLOROPHENYL)2 HYDROXY NONANOIC ACID AMIDE; 2 (TERT BUTYL) 5 (3 CHLOROPHENYL) 1,3 DIOXOLAN 4 ONE; 2 (TERT BUTYL) 5 (3 CHLOROPHENYL) 5 HEPTYL 1,3 DIOXOLAN 4 ONE; 3 CHLOROMANDELIC ACID; ANTINEOPLASTIC AGENT; HYDROXYPHENYLAMIDE VOLTAGE GATED SODIUM CHANNEL BLOCKER BLOCKER; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING ASSAY; CHIRALITY; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; MOUSE; NONHUMAN; PROSTATE CANCER; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING; X RAY CRYSTALLOGRAPHY;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; HUMANS; ION CHANNEL GATING; ISOMERISM; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MODELS, MOLECULAR; PROSTATE; PROSTATIC NEOPLASMS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 84862815786     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.061     Document Type: Article

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