Gel microstructure regulates proliferation and differentiation of MC3T3-E1 cells encapsulated in alginate beads

Acta Biomaterialia

Volumn 8, Issue 5, 2012, Pages 1693-1702

  Lee, Baek Hee ^a,b   Li, Bing ^a,b   Guelcher, Scott A ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alginate; Differentiation; Encapsulation; Microstructure; Proliferation

Indexed keywords

BIOMECHANICS; CELL DEATH; CHLORINE COMPOUNDS; DENSITY (SPECIFIC GRAVITY); HYDROGELS; MESH GENERATION; NUTRIENTS; PHOSPHATASES; SODIUM ALGINATE;

ALGINATE BEADS; ALGINATE HYDROGELS; CELL TRANSPLANTATION; DEFECT SITES; DIFFERENTIATION; MC3T3-E1 CELL; MESH SIZE; OSTEOPROGENITOR CELLS; PROLIFERATION; VIABLE CELLS;

MICROSTRUCTURE;

ALGINIC ACID; ALKALINE PHOSPHATASE; CALCIUM CHLORIDE; OSTEOCALCIN; SODIUM; WATER;

ARTICLE; CELL DIFFERENTIATION; CELL ENCAPSULATION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL SURVIVAL; CELL VIABILITY; CHEMICAL COMPOSITION; DENSITY; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; HYDROGEL; MICROSCOPY; MOLECULAR MECHANICS; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN SECRETION; REGULATORY MECHANISM; SHEAR STRENGTH; STEM CELL; WETTABILITY; YOUNG MODULUS;

EID: 84862814576     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.01.012     Document Type: Article

References (53)

1. R.M. Hernandez, G. Orive, A. Murua, and J.L. Pedraz Microcapsules and microcarriers for in situ cell delivery Adv Drug Deliv Rev 62 2010 711 730
2. W. Zhang, L. Tucker-Kellogg, B.C. Narmada, L. Venkatraman, S. Chang, and Y. Lu Cell-delivery therapeutics for liver regeneration Adv Drug Deliv Rev 62 2010 814 826
3. B.B. Mandal, and S.C. Kundu Calcium alginate beads embedded in silk fibroin as 3D dual drug releasing scaffolds Biomaterials 30 2009 5170 5177
4. H. Zhou, and H.H. Xu The fast release of stem cells from alginate-fibrin microbeads in injectable scaffolds for bone tissue engineering Biomaterials 32 2011 7503 7513
5. C. Wang, Y. Gong, Y. Lin, J. Shen, and D.A. Wang A novel gellan gel-based microcarrier for anchorage-dependent cell delivery Acta Biomater 4 2008 1226 1234
6. A.J. Wagers, and I.L. Weissman Plasticity of adult stem cells Cell 116 2004 639 648
7. D.J. Mooney, and H. Vandenburgh Cell delivery mechanisms for tissue repair Cell Stem Cell 2 2008 205 213
8. M. Hofmann, K.C. Wollert, G.P. Meyer, A. Menke, L. Arseniev, and B. Hertenstein Monitoring of bone marrow cell homing into the infarcted human myocardium Circulation 111 2005 2198 2202
9. S.M. Evans, C. Mummery, and P.A. Doevendans Progenitor cells for cardiac repair Semin Cell Dev Biol 18 2007 153 160
10. G. Orive, M. De Castro, H.J. Kong, R.M. Hernandez, S. Ponce, and D.J. Mooney Bioactive cell-hydrogel microcapsules for cell-based drug delivery J Control Release 135 2009 203 210
11. N. Wang, G. Adams, L. Buttery, F.H. Falcone, and S. Stolnik Alginate encapsulation technology supports embryonic stem cells differentiation into insulin-producing cells J Biotechnol 144 2009 304 312
12. J. Wikstrom, M. Elomaa, H. Syvajarvi, J. Kuokkanen, M. Yliperttula, and P. Honkakoski Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy Biomaterials 29 2008 869 876
13. C.S. Chen, M. Mrksich, S. Huang, G.M. Whitesides, and D.E. Ingber Geometric control of cell life and death Science 276 1997 1425 1428
14. J.A. Burdick, and G. Vunjak-Novakovic Engineered microenvironments for controlled stem cell differentiation Tissue Eng Part A 15 2009 205 219
15. R. Singhvi, A. Kumar, G.P. Lopez, G.N. Stephanopoulos, D.I. Wang, and G.M. Whitesides Engineering cell shape and function Science 264 1994 696 698
16. J.Y. Lim, and H.J. Donahue Cell sensing and response to micro- and nanostructured surfaces produced by chemical and topographic patterning Tissue Eng 13 2007 1879 1891
17. T. Fuhrmann, L.M. Hillen, K. Montzka, M. Woltje, and G.A. Brook Cell-cell interactions of human neural progenitor-derived astrocytes within a microstructured 3D-scaffold Biomaterials 31 2010 7705 7715
18. M. Kuppers, D. Faust, B. Linz, and C. Dietrich Regulation of ERK1/2 activity upon contact inhibition in fibroblasts Biochem Biophys Res Commun 406 2011 483 487
19. H. Eagle, and E.M. Levine Growth regulatory effects of cellular interaction Nature 213 1967 1102 1106
20. Q. Zeng, and W. Hong The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals Cancer Cell 13 2008 188 192
21. A.W. Chan, and R.J. Neufeld Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics Biomaterials 31 2010 9040 9047
22. K.H. Bouhadir, K.Y. Lee, E. Alsberg, K.L. Damm, K.W. Anderson, and D.J. Mooney Degradation of partially oxidized alginate and its potential application for tissue engineering Biotechnol Prog 17 2001 945 950
23. L. Zhao, M.D. Weir, and H.H. Xu An injectable calcium phosphate-alginate hydrogel-umbilical cord mesenchymal stem cell paste for bone tissue engineering Biomaterials 31 2010 6502 6510
24. O. Jeon, K.H. Bouhadir, J.M. Mansour, and E. Alsberg Photocrosslinked alginate hydrogels with tunable biodegradation rates and mechanical properties Biomaterials 30 2009 2724 2734
25. J.A. Rowley, G. Madlambayan, and D.J. Mooney Alginate hydrogels as synthetic extracellular matrix materials Biomaterials 20 1999 45 53
26. M.B. Evangelista, S.X. Hsiong, R. Fernandes, P. Sampaio, H.J. Kong, and C.C. Barrias Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix Biomaterials 28 2007 3644 3655
27. A.D. Augst, H.J. Kong, and D.J. Mooney Alginate hydrogels as biomaterials Macromol Biosci 6 2006 623 633
28. J.A. Rowley, and D.J. Mooney Alginate type and RGD density control myoblast phenotype J Biomed Mater Res 60 2002 217 223
29. W.A. Comisar, N.H. Kazmers, D.J. Mooney, and J.J. Linderman Engineering RGD nanopatterned hydrogels to control preosteoblast behavior: a combined computational and experimental approach Biomaterials 28 2007 4409 4417
30. K.B. Fonseca, S.J. Bidarra, M.J. Oliveira, P.L. Granja, and C.C. Barrias Molecularly designed alginate hydrogels susceptible to local proteolysis as three-dimensional cellular microenvironments Acta Biomater 7 2011 1674 1682
31. O. Jeon, C. Powell, S.M. Ahmed, and E. Alsberg Biodegradable, photocrosslinked alginate hydrogels with independently tailorable physical properties and cell adhesivity Tissue Eng Part A 16 2010 2915 2925
32. U. Zimmermann, F. Thurmer, A. Jork, M. Weber, S. Mimietz, and M. Hillgartner A novel class of amitogenic alginate microcapsules for long-term immunoisolated transplantation Ann N Y Acad Sci 944 2001 199 215
33. D.E. Discher, P. Janmey, and Y.L. Wang Tissue cells feel and respond to the stiffness of their substrate Science 310 2005 1139 1143
34. B.G. Choi, M.H. Park, S.H. Cho, M.K. Joo, H.J. Oh, and E.H. Kim In situ thermal gelling polypeptide for chondrocytes 3D culture Biomaterials 31 2010 9266 9272
35. A.J. Engler, S. Sen, H.L. Sweeney, and D.E. Discher Matrix elasticity directs stem cell lineage specification Cell 126 2006 677 689
36. H.J. Kong, J. Liu, K. Riddle, T. Matsumoto, K. Leach, and D.J. Mooney Non-viral gene delivery regulated by stiffness of cell adhesion substrates Nat Mater 4 2005 460 464
37. S. Taqvi, and K. Roy Influence of scaffold physical properties and stromal cell coculture on hematopoietic differentiation of mouse embryonic stem cells Biomaterials 27 2006 6024 6031
38. P.M. Gilbert, K.L. Havenstrite, K.E. Magnusson, A. Sacco, N.A. Leonardi, and P. Kraft Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture Science 329 2010 1078 1081
39. N.S. Ruppender, A.R. Merkel, T.J. Martin, G.R. Mundy, J.A. Sterling, and S.A. Guelcher Matrix rigidity induces osteolytic gene expression of metastatic breast cancer cells PLoS One 5 2010 e15451
40. L.H. Sperling Introduction to physical polymer science 3rd ed. 2001 Wiley-Interscience New York
41. G.P. Raeber, M.P. Lutolf, and J.A. Hubbell Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration Biophys J 89 2005 1374 1388
42. O. Smidsrod Soution properties of alginate Carbohydr Res 13 1970 359 372
43. A.W. Chan, and R.J. Neufeld Modeling the controllable pH-responsive swelling and pore size of networked alginate based biomaterials Biomaterials 30 2009 6119 6129
44. T. Caykara, and R. Inam Determination of average molecular weight between crosslinks and polymer-solvent interaction parameters of poly(acrylamide-g- ethylene diamine tetraacetic acid) polyelectrolyte hydrogels J Appl Polym Sci 91 2004 2168 2175
45. B. Amsden, and N. Turner Diffusion characteristics of calcium alginate gels Biotechnol Bioeng 65 1999 605 610
46. S.T. Moe, K.I. Draget, G. Skjak-Braek, and O. Smidsrod Temperature dependence of the elastic modulus of alginate gels Carbohydr Polym 19 1992 279 284
47. O. Jeon, S.J. Song, K.-J. Lee, M.H. Park, S.-H. Lee, and S.K. Hahn Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities Carbohydr Polym 70 2007 251 257
48. K.Y. Lee, and D.J. Mooney Alginate: properties and biomedical applications Prog Polym Sci 37 2012 106 126
49. M. Davidovich-Pinhas, and H. Bianco-Peled A quantitative analysis of alginate swelling Carbohydr Polym 79 2010 1020 1027
50. H.J. Kong, K.Y. Lee, and D.J. Mooney A quantitative analysis of alginate swelling Macromolecules 36 2003 7887 7890
51. A. Martinsen, I. Storro, and G. Skjark-Braek Alginate as immobilization material: III. Diffusional properties Biotechnol Bioeng 39 1992 186 194
52. E.R. West, M. Xu, T.K. Woodruff, and L.D. Shea Physical properties of alginate hydrogels and their effects on in vitro follicle development Biomaterials 28 2007 4439 4448
53. S.A. Abbah, W.W. Lu, D. Chan, K.M. Cheung, W.G. Liu, and F. Zhao Osteogenic behavior of alginate encapsulated bone marrow stromal cells: an in vitro study J Mater Sci Mater Med 19 2008 2113 2119