Matrix rigidity induces osteolytic gene expression of metastatic breast cancer cells

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Ruppender, Nazanin S ^a,b   Merkel, Alyssa R ^b   Martin, T John ^b,e   Mundy, Gregory R ^b,c   Sterling, Julie A ^b,c,d   Guelcher, Scott A ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR; MYOSIN ADENOSINE TRIPHOSPHATASE; RHO KINASE; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN;

ARTICLE; BONE MATRIX; BONE MINERALIZATION; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMAGING; MECHANOTRANSDUCTION; METASTASIS POTENTIAL; MUSCLE CONTRACTILITY; OSTEOLYSIS; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RIGIDITY; SIGNAL TRANSDUCTION; ALGORITHM; BONE TUMOR; BREAST TUMOR; CULTURE TECHNIQUE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENE REGULATORY NETWORK; GENETICS; METABOLISM; METASTASIS; METHODOLOGY; OSTEOCLAST; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; TUMOR MICROENVIRONMENT;

ALGORITHMS; BONE NEOPLASMS; BREAST NEOPLASMS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; HUMANS; NEOPLASM METASTASIS; OSTEOCLASTS; OSTEOLYSIS; PARATHYROID HORMONE-RELATED PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHO-ASSOCIATED KINASES; TRANSFORMING GROWTH FACTOR BETA; TUMOR MICROENVIRONMENT;

EID: 78649732806     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015451     Document Type: Article

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