Development and validation of a rapid high-performance liquid chromatography-tandem mass spectrometry method for the determination of WJ-38, a novel aldose reductase inhibitor, in rat plasma and its application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 893-894, Issue , 2012, Pages 29-33

  Lu, Jing ^a   Liu, Youping ^a   Wang, Xin ^a   Wang, Shaojie ^a   Di, Xin ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Aldose reductase inhibitor; Liquid chromatography tandem mass spectrometry; Pharmacokinetics; Rat plasma; WJ 38

Indexed keywords

ALDOSE REDUCTASE INHIBITORS; CHROMATOGRAPHIC SEPARATIONS; CONCENTRATION RANGES; ETHYL ACETATES; EXTRACTION RECOVERY; GLIPIZIDE; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; INTERNAL STANDARDS; ION TRANSITION; IONIZATION MODES; ISOCRATIC MOBILE PHASE; LINEAR CALIBRATION CURVE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; MASS SPECTROMETRIC DETECTION; PARTIAL DENATURATION; PHARMACOKINETIC STUDIES; PLASMA PROTEIN; RAT PLASMA; SELECTED REACTION MONITORING; TRIPLE-QUADRUPOLE MASS SPECTROMETER; VALIDATED METHODS; WJ-38;

ACETONITRILE; CHROMATOGRAPHY; FORMIC ACID; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS;

BODY FLUIDS;

2 [6 METHOXY 3 (2,3 DICHLOROPHENYL)METHYL 4 OXO 1 (4H)QUINOLINYL]ACETIC ACID; ACETIC ACID ETHYL ESTER; ACETONITRILE; ALDOSE REDUCTASE INHIBITOR; ANTIDIABETIC AGENT; FORMIC ACID; GLIPIZIDE; METHANOL; UNCLASSIFIED DRUG; WATER; WJ 38;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DENATURATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG PROTEIN BINDING; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ALDEHYDE REDUCTASE; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; ENZYME INHIBITORS; FEMALE; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84862812003     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.02.024     Document Type: Article

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