Synthesis and activity of a new series of (Z)-3-phenyl-2-benzoylpropenoic acid derivatives as aldose reductase inhibitors

Molecules

Volumn 12, Issue 4, 2007, Pages 885-895

  Wang, Shao Jie ^a   Yan, Ju Fang ^b   Hao, Dong ^a   Niu, Xin Wen ^a   Cheng, Mao Sheng ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Drug Screening Center   (China)

Author keywords

(Z) 3 phenyl 2 benzoylpropenoic acid; Aldose reductase inhibitor; Structureactivity relationships

Indexed keywords

ALDEHYDE REDUCTASE; ALR2 PROTEIN, HUMAN; AMINO ACID; BENZOIC ACID DERIVATIVE; BENZOYLPROPIONIC ACID; ENZYME INHIBITOR; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; HYDROGEN BOND; IC 50; METHODOLOGY; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; AMINO ACIDS; BENZOATES; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROPIONATES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247857626     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/12040885     Document Type: Article

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