Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4′-piperidine]-2-ones as potential c-Met inhibitors

European Journal of Medicinal Chemistry

Volumn 50, Issue , 2012, Pages 370-375

  Ye, Lianbao ^a,b   Tian, Yuanxin ^a   Li, Zhonghuang ^a   Jin, Hong ^a   Zhu, Zhengguang ^a   Wan, Shanhe ^a   Zhang, Junyan ^a   Yu, Pengjiu ^a   Zhang, Jiajie ^a   Wu, Shuguang ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

C Met inhibitor; Molecular docking; Spiro indoline 3, 4 piperidine 2 ones; Suzuki coupling reaction

Indexed keywords

PIPERIDINE DERIVATIVE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SPIRO[INDOLINE 3,4' PIPERIDINE] 2 ONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING;

BINDING SITES; BLOTTING, WESTERN; CELL PROLIFERATION; DRUG DESIGN; DRUG DISCOVERY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MET; STOMACH NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84862811684     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.02.016     Document Type: Article

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