Verification of brain penetration of the unbound fraction of a novel HER2/EGFR dual kinase inhibitor (TAK-285) by microdialysis in rats

Brain Research Bulletin

Volumn 87, Issue 4-5, 2012, Pages 413-419

  Erdo, Franciska ^a   Gordon, Justin ^b   Wu, Jing Tao ^b   Sziráki, István ^a,c  

^a SOLVO BIOTECHNOLOGY   (Hungary)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c Trans Neuropharma Lpc   (Hungary)

Author keywords

Adsorption to outflow tubing; Brain and blood microdialysis; Brain penetration; Perfusion with BSA; TAK 285

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN KINASE INHIBITOR; TAK 285; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BRAIN; BRAIN METASTASIS; BREAST CANCER; CONTROLLED STUDY; DIALYSATE; DRUG PENETRATION; EXTRACELLULAR SPACE; FLOW RATE; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CHROMATOGRAPHY, LIQUID; HYDROXYBUTYRATES; MALE; MICRODIALYSIS; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

EID: 84862810837     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2012.01.002     Document Type: Article

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