TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice

Pflugers Archiv European Journal of Physiology

Volumn 463, Issue 5, 2012, Pages 727-732

  Li, Li ^a   Chen, Jing ^a   Ni, Yinxing ^a   Feng, Xiaoli ^a   Zhao, Zhigang ^a   Wang, Peijian ^a   Sun, Jing ^a   Yu, Hao ^a   Yan, Zhencheng ^a   Liu, Daoyan ^a   Nilius, Bernd ^b   Zhu, Zhiming ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

Author keywords

Capsaicin; Fatty liver; TRPV1; UCP2

Indexed keywords

CAPSAICIN; TRIACYLGLYCEROL; VANILLOID RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; HIGH RISK POPULATION; HUMAN; HUMAN CELL; LIPID DIET; LIPID STORAGE; LIVER CELL; LIVER PARENCHYMA; MALE; MOUSE; MOUSE STRAIN; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; CAPSAICIN; CELLS, CULTURED; DIET, HIGH-FAT; DIETARY FATS, UNSATURATED; FATTY LIVER; HEP G2 CELLS; HEPATOCYTES; HUMANS; ION CHANNELS; LIVER; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; TRIGLYCERIDES; TRPV CATION CHANNELS; UP-REGULATION;

EID: 84862807525     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-012-1078-y     Document Type: Article

References (26)

1. Baffy G (2005) Uncoupling protein-2 and non-alcoholic fatty liver disease. Front Biosci 10:2082-2096
2. Bellentani S, Dalle Grave R, Suppini A, Marchesini G (2008) Behavior therapy for nonalcoholic fatty liver disease: the need for a multidisciplinary approach. Hepatology 47:746-754
3. Cho KW, Kim YO, Andrade JE, Burgess JR, Kim YC (2011) Dietary naringenin increases hepatic peroxisome proliferators-activated receptor alpha protein expression and decreases plasma triglyceride and adiposity in rats. Eur J Nutr 50:81-88
4. Dowman JK, Armstrong MJ, Tomlinson JW, Newsome PN (2011) Current therapeutic strategies in non-alcoholic fatty liver disease. Diabetes Obes Metab 13:692-702
5. Gees M, Colsoul B, Nilius B (2010) The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol 2:a003962
6. Ma ST, Zhang LL, Yang DC, Ma LQ, Luo ZD, Liu DY, Zhu ZM (2010) Dietary capsaicin upregulates uncoupling protein 2/3 expression in visceral adipose tissue and enhances acetylcholineinduced hypotensive effect in mice. Prog Nutr 12:19-23
7. Malavazos AE, Gobbo G, Zelaschi RF, Cereda E (2010) Lifestyle intervention and fatty liver disease: the importance of both disrupting inflammation and reducing visceral fat. Hepatology 51:1091-1092
8. Masterjohn C, Bruno RS (2012) Therapeutic potential of green tea in nonalcoholic fatty liver disease. Nutr Rev 70:41-56
9. Messmer TO, Wang E, Stevens VL, Merrill AH Jr (1989) Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins. J Nutr 119:534-538
10. Miao X, Liu G, Xu X, Xie C, Sun F, Yang Y, Zhang T, Hua S, FanW, Li Q, Huang S, Wang Q, Zhong D (2008) High expression of vanilloid receptor-1 is associated with better prognosis of patients with hepatocellular carcinoma. Cancer Genet Cytogenet 186:25-32
11. Mulvihill EE, Allister EM, Sutherland BG, Telford DE, Sawyez CG, Edwards JY, Markle JM, Hegele RA, Huff MW (2009) Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes 58:2198-2210
12. Nilius B (2007) TRP channels in disease. Biochim Biophys Acta 1772:805-812
13. Nilius B, Owsianik G, Voets T, Peters JA (2007) Transient receptor potential cation channels in disease. Physiol Rev 87:165-217
14. Nilius B, Appendino G (2011) Tasty and healthy TR(i)Ps. The human quest for culinary pungency. EMBO Rep 12:1094-1101
15. Oh KS, Kim M, Lee J, Kim MJ, Nam YS, Ham JE, Shin SS, Lee CM, Yoon M (2006) Liver PPARalpha and UCP2 are involved in the regulation of obesity and lipid metabolism by swim training in genetically obese db/db mice. Biochem Biophys Res Commun 345:1232-1239
16. Palmieri F (2004) The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch 447:689-709
17. Schrauwen P, Hesselink M (2002) UCP2 and UCP3 in muscle controlling body metabolism. J Exp Biol 205:2275-2285
18. Scorletti E, Calder PC, Byrne CD (2011) Non-alcoholic fatty liver disease and cardiovascular risk: metabolic aspects and novel treatments. Endocrine 40:332-343
19. Sheets AR, Fulop P, Derdak Z, Kassai A, Sabo E, Mark NM, Paragh G, Wands JR, Baffy G (2008) Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice. Am J Physiol Gastrointest Liver Physiol 294:G1017-G1024
20. Targher G, Day CP, Bonora E (2010) Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 363:1341-1350
21. Vriens J, Janssens A, Prenen J, Nilius B, Wondergem R (2004) TRPV channels and modulation by hepatocyte growth factor/ scatter factor in human hepatoblastoma (HepG2) cells. Cell Calcium 36:19-28
22. Yachi R, Igarashi O, Kiyose C (2010) Protective effects of vitamin E analogs against carbon tetrachloride-induced fatty liver in rats. J Clin Biochem Nutr 47:148-154
23. Yang D, Luo Z, Ma S, Wong WT, Ma L, Zhong J, He H, Zhao Z, Cao T, Yan Z, Liu D, Arendshorst WJ, Huang Y, Tepel M, Zhu Z (2010) Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab 12:130-141
24. Yanni AE, Agrogiannis G, Nomikos T, Fragopoulou E, Pantopoulou A, Antonopoulou S, Perrea D (2010) Oral supplementation with Laspartate and L-glutamate inhibits atherogenesis and fatty liver disease in cholesterol-fed rabbit. Amino Acids 38:1323-1331
25. Zhang LL, Yan Liu D, Ma LQ, Luo ZD, Cao TB, Zhong J, Yan ZC, Wang LJ, Zhao ZG, Zhu SJ, Schrader M, Thilo F, Zhu ZM, Tepel M (2007) Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ Res 100:1063-1070
26. Zhong J, Minassi A, Prenen J, Taglialatela-Scafati O, Appendino G, Nilius B (2011) Umbellulone modulates TRP channels. Pflugers Arch 462:861-870