Dietary capsaicin upregulates uncoupling protein 2/3 expression in visceral adipose tissue and enhances acetylcholine-induced hypotensive effect in mice

Progress in Nutrition

Volumn 12, Issue 1, 2010, Pages 19-23

  Ma, S T ^a   Zhang, L L ^a   Yang, D C ^a   Ma, L Q ^a   Luo, Z D ^a   Liu, D Y ^a   Zhu, Zhiming ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Capsaicin; Hypotension; Transient receptor potential vanilloid type 1; Uncoupling protein

Indexed keywords

ACETYLCHOLINE; CAPSAICIN; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; VANILLOID RECEPTOR 1;

ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; INTRAABDOMINAL FAT; LIPID DIET; MOUSE; NONHUMAN; OBESITY; OXIDATION; PROTEIN EXPRESSION; UPREGULATION;

CAPSICUM FRUTESCENS; MUS;

EID: 77953884620     PISSN: 11298723     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension 2006; 47: 296-308. (Pubitemid 43189776)
2. Lichtenstein AH, Appel LJ, Brands M, et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006; 114: 82-96.
3. Ong KL, Cheung BM, Man YB, Lau CP, Lam KS. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 2007; 49: 69-75.
4. Kang JH, Kim CS, Han IS, Kawada T, Yu R. Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Lett 2007; 581: 4389-96. (Pubitemid 47368195)
5. Hachiya S, Kawabata F, Ohnuki K, et al. Effects of CH-19 Sweet, a non-pungent cultivar of red pepper, on sympathetic nervous activity, body temperature, heart rate, and blood pressure in humans. Biosci Biotechnol Biochem 2007; 71: 671-6. (Pubitemid 46481444)
6. Chan SH, Wu CA, Wu KL, Ho YH, Chang AY, Chan JY. Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension. Circ Res 2009; 105: 886-96.
7. Zhang LL, Yan Liu D, Ma LQ, et al. Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ Res 2007; 100: 1063-70.
8. Wang S, Subramaniam A, Cawthorne MA, Clapham JC. Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle. Diabetes Obes Metab 2003; 5: 295-301. (Pubitemid 37138859)
9. Schrauwen P, Hesselink M. UCP2 and UCP3 in muscle controlling body metabolism. J Exp Biol 2002; 205: 2275-85.
10. Ohnuki K, Haramizu S, Oki K, Watanabe T, Yazawa S, Fushiki T. Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. Biosci Biotechnol Biochem 2001; 65: 2735-40. (Pubitemid 33617864)
11. Krempler F, Esterbauer H, Weitgasser R, et al. A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes 2002; 51: 3331-5. (Pubitemid 35246982)
12. Porszasz R, Porkolab A, Ferencz A, Pataki T, Szilvassy Z, Szolcsanyi J. Capsaicin-induced nonneural vasoconstriction in canine mesenteric arteries. Eur J Pharmacol 2002; 441: 173-5. (Pubitemid 34626168)