Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 8, 2012, Pages 2721-2738

  Smith, Aaron L ^a,b   Freeman, Sara M ^b   Stehouwer, Jeffery S ^a   Inoue, Kiyoshi ^b   Voll, Ronald J ^a   Young, Larry J ^b   Goodman, Mark M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Autoradiography; Iodine 125; Oxytocin; Receptors; Vasopressin

Indexed keywords

1 (1 (2 (2 (3 [IODINE 125] IODOALLYLOXY) 4 (1 (METHYLSULFONYL)PIPERIDIN 4 YLOXY)PHENYL)ACETYL)PIPERIDIN 4 YL) 3,4 DIHYDROQUINOLIN 2 (1H) ONE ([IODINE 125]); 1 (1 (2 (2 (3 IODOALLYLOXY) 4 (1 (METHYLSULFONYL)PIPERIDIN 4 YLOXY)PHENYL)ACETYL)PIPERIDIN 4 YL) 3,4 DIHYDROQUINOLIN 2 (1H) ONE; 1 (1 (2 (2 [CARBON 11] METHOXY 4 ((1 (METHYLSULFONYL)PIPERIDIN 4 YL)OXY)PHENYL)ACETYL)PIPERIDIN 4 YL) 3,4 DIHYDROQUINOLIN 2 (1H) ONE ([CARBON 11] 4); 1 (1 (2 (2 HYDROXY 4 (1 (METHYLSULFONYL)PIPERIDIN 4 YLOXY)PHENYL)ACETYL)PIPERIDIN 4 YL) 3,4 DIHYDROQUINOLIN 2 (1H) ONE; 1 (1 (2 (2 HYDROXY 4 (PIPERIDIN 4 YLOXY)PHENYL)ACETYL)PIPERIDIN 4 YL) 3,4 DIHYDROQUINOLIN 2 (1H) ONE; 1 (1 (2 (4 (1 (METHYLSULFONYL)PIPERIDIN 4 YLOXY) 2 (3 (TRIBUTYLSTANNYL)ALLYLOXY)PHENYL)ACETYL)PIPERIDIN 4 YL) 3,4 DIHYDROQUINOLIN 2 (1H) ONE; 1 (4 (3,4 DIHYDROQUINOLIN 1 (2H) YL)PIPERIDIN 1 YL) 2 (2 (2 [FLUORODEOXYGLUCOSE 18] FLUOROETHOXY) 4 ((1 (METHYLSULFONYL)PIPERIDIN 4 YL)OXY)PHENYL)ETHANONE ([FLUORODEOXYGLUCOSE 18] 3); 1 (4 (3,4 DIHYDROQUINOLIN 1 (2H) YL)PIPERIDIN 1 YL) 2 (2 (2 FLUOROETHOXY) 4 ((1 (METHYLSULFONYL)PIPERIDIN 4 YL)OXY)PHENYL)ETHANONE; 2 (4 (1 (TERT BUTOXYCARBONYL)PIPERIDIN 4 YLOXY) 2 (METHOXYMETHOXY)PHENYL)ACETIC ACID; 2 (5 ((1 (METHYLSULFONYL)PIPERIDIN 4 YL)OXY) 2 (2 OXO 2 (4 (2 OXO 3,4 DIHYDROQUINOLIN 1 (2H) YL)PIPERIDIN 1 YL)ETHYL)PHENOXY)ETHYL 4 METHYLBENZENESULFONIC ACID; CARBON 11; FLUORODEOXYGLUCOSE F 18; IODINE 125; OXYTOCIN RECEPTOR; TERT BUTYL 4 (3 (METHOXYMETHOXY) 4 (2 OXO 2 (4 (2 OXO 3,4 DIHYDROQUINOLIN 1 (2H) YL)PIPERIDINE 1 YL)ETHYL)PHENOXY)PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 4 (4 ACETYL 3 (METHOXYMETHOXY)PHENOXY)PIPERIDINE 1 CARBOXYLIC ACID; TERT BUTYL 4 (4 ACETYL 3 HYDROXYPHENOXY)PIPERIDINE 1 CARBOXYLIC ACID; UNCLASSIFIED DRUG; VASOPRESSIN V1A RECEPTOR;

ALKYLATION; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING ASSAY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DISTRIBUTION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HYPOTHALAMUS; ISOTOPE LABELING; LIGAND BINDING; LIPOPHILICITY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOACTIVITY; RAT; RECEPTOR BINDING; TISSUE DISTRIBUTION;

ANIMALS; ARVICOLINAE; AUTORADIOGRAPHY; BINDING, COMPETITIVE; CARBON ISOTOPES; CELL LINE; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; IODINE RADIOISOTOPES; LIGANDS; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; QUINOLINES; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OXYTOCIN; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

PRIMATES; RATTUS; RODENTIA;

EID: 84862804471     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.019     Document Type: Article

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