Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2866-2871

  Ding, Min ^a   He, Feng ^a   Hudyma, Thomas W ^a   Zheng, Xiaofan ^a   Poss, Michael A ^a   Kadow, John F ^a   Beno, Brett R ^a   Rigat, Karen L ^a   Wang, Ying Kai ^a   Fridell, Robert A ^a   Lemm, Julie A ^a   Qiu, Dike ^a   Liu, Mengping ^a   Voss, Stacey ^a   Pelosi, Lenore A ^a   Roberts, Susan B ^a   Gao, Min ^a   Knipe, Jay ^a   Gentles, Robert G ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

HCV NS5B polymerase inhibitors; Tetracyclic indoles

Indexed keywords

BOCEPREVIR; DIAMIDE; INDOLE DERIVATIVE; NONSTRUCTURAL PROTEIN 5B; PYRIDINE DERIVATIVE; RNA DIRECTED RNA POLYMERASE; RNA DIRECTED RNA POLYMERASE INHIBITOR; TELAPREVIR;

ALLOSTERISM; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONFORMATIONAL TRANSITION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GENOTYPE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALLOSTERIC REGULATION; AMIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; HEPACIVIRUS; HETEROCYCLIC COMPOUNDS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 84862802756     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.063     Document Type: Article

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