Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects

Acta Pharmacologica Sinica

Volumn 30, Issue 5, 2009, Pages 567-575

  Shi, Qian ^a   Liu, Ze ^a   Yang, Yang ^a   Geng, Peng ^b   Zhu, Yuan Yuan ^a   Zhang, Qi ^a   Bai, Fang ^a   Bai, Gang ^a  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Antitussive; Asthma; Beta2 adrenergic receptor ( 2AR) agonists; Bronchodilator; Pericarpium citri reticulatae (PCR); Stachydrine; Synephrine

Indexed keywords

ACETYLCHOLINE; ANTITUSSIVE AGENT; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CITRIC ACID; CITRUS RETICULATA EXTRACT; HISTAMINE; ION EXCHANGE RESIN; OXEDRINE; PLANT EXTRACT; PROPRANOLOL; SALBUTAMOL; STACHYDRINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHOSPASM; CHINESE MEDICINE; CONTROLLED STUDY; COUGHING; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENTIATION; DRUG PURIFICATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MANDARIN; NONHUMAN; PERICARP; SPASMOLYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

ADRENERGIC BETA-AGONISTS; ALKALOIDS; ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; CHO CELLS; CITRUS; COUGH; CRICETINAE; CRICETULUS; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; DRUGS, CHINESE HERBAL; FEMALE; GUINEA PIGS; PLANT EXTRACTS; PROLINE; SYNEPHRINE;

EID: 66749098525     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.36     Document Type: Article

References (25)

1. The Public Health Department of People's Republic of China. Pharmacopoeia of the People's Republic of China. Beijing: Chemical Industry Press; 2000. vol 1: p 148-9.
2. Editor Committee for the Encyclopedia of Chinese traditional medicines. Encyclopedia of Chinese traditional medicines. Beijing: Encyclopedia of China Publishing House; 1999. vol 4: p 886-91.
3. 2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells. Mol Pharmacol 2008; 73: 203-14.
4. Annesi-Maesano I. Asthma epidemiology. Rev Prat. 2005; 55: 1295-8.
5. Rabe KF, Schmidt DT. Pharmacological treatment of asthma today. Eur Respir J Suppl 2001; 34: 34s-40s.
6. Fang SP, Tanaka T, Tago F, Okamoto T, Kojima S. Immunomodu-latory effects of gyokuheifusan on INF-gamma/IL-4 (Th1/Th2) balance in ovalbumin (OVA)-induced asthma model mice. Biol Pharm Bull 2005; 28: 829-33.
7. Lee SK, Wong CK, Sung RY, Leung TF, Fung KP, Leung PC, et al. In vitro anti-allergic activities of a newly concocted traditional Chinese medicine-the wheeze-relief formula. J Ethnopharmacol 2006; 103: 406-12.
8. Hill SJ, Baker JG, Rees S. Reporter-gene systems for the study of G-protein-coupled receptors. Curr Opin Pharmacol 2001; 1: 526-32.
9. Montminy MR, Gonzalez GA, Yamamoto KK. Regulation of cAMP-inducible genes by CREB. Trends Neurosci 1990; 13: 184-8.
10. Lalli E, Sassone-Corsi P. Signal transduction and gene regulation: the nuclear response to cAMP. J Biol Chem 1994; 269: 17359-62.
11. Chen J, Bai G, Yang Y, Geng P, Cao Y, Zhu Y. Identifying glucagon-like peptide-1 mimetics using a novel functional reporter gene high-throughput screening assay. Peptides 2007; 28: 928-34.
12. Durocher Y, Perret S, Thibaudeau E, Gaumond MH, Kamen A, Stocco R, et al. A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture. Anal Bio-chem 2000; 284: 316-26.
13. Kunapuli P, Ransom R. Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening. Anal Biochem 2003; 314: 16-29.
14. Bai G, Yang Y, Shi Q, Liu Z, Zhang Q, Zhu YY. Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist. Acta Pharmacol Sin 2008; 29: 1187-94.
15. Forsberg K, Karlsson JA, Teodorsson E, Lundberg JM, Persson CG. Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig. Pulm Pharmacol 1988; 1: 33-9.
16. Chu X, Xu Z, Wu D, Zhao A, Zhou M, Qiu M, et al. In vitro and in vivo evaluation of the anti-asthmatic activities of fractions from Pheretima. J Ethnopharmacol 2007; 111: 490-5.
17. Hashiba E, Sato T, Hirota K, Hashimoto Y, Matsuki A. The relaxant effect of propofol on guinea pig tracheal muscle is independ ent of airway epithelial function and β-adrenoceptor activity. Anesth Analg 1999; 89: 191-6.
18. Vogel HG, Vogel WH. Drug discovery and evaluation: pharmacological assays. Springer-Verlag: Berlin Heidelberg; 1997.
19. Lin FY, Chen YH, Chen YL, Wu TC, Li CY, Chen JW, et al. Ginkgo biloba extract inhibits endotoxin-induced human aortic smooth muscle cell proliferation via suppression of toll-like receptor 4 expression and NADPH oxidase activation. J Agric Food Chem 2007; 55: 1977-84.
20. Takei H, Hirabuki M, Yoshizaki F. Analysis of synephrine in the peel of citrus fruit, immature citrus fruit and decoctions of Chinese medicinal prescriptions containing these crude drugs by capillary electrophoresis. Anal Sci 1999; 15: 1017-20.
21. Fugh-Bergman A, Myers A. Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research. Exp Biol Med (Maywood) 2004; 229: 698-704.
22. Dicpinigaitis PV. Chronic cough due to asthma: ACCP evidence-based clinical practice guidelines. Chest 2006; 129: 75S-9S.
23. Trinchant JC, Boscari A, Spennato G, Van de Sype G, Le Rudulier D. Proline betaine accumulation and metabolism in alfalfa plants under sodium chloride stress. Exploring its compartmentalization in nodules. Plant Physiol 2004; 135: 1583-94.
24. Satyanarayana T, Mathews AA, Vijetha P. Phytochemical and pharmaco logical review of some Indian Capparis species. Phcog Rev 2008; 2 (4 Suppl): 36-45.
25. Barnes PJ. Efect of nedocromil sodium on airway sensory nerves. J Allergy Clin Immunol 1993; 92: 182-6.