Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs

Vaccine

Volumn 30, Issue 7, 2012, Pages 1297-1304

  Pyo, Hyun Mi ^a   Masic, Aleksandar ^b   Woldeab, Nizihti ^b   Embury Hyatt, Carissa ^c   Lin, Li ^a   Shin, Yeun Kyung ^d   Song, Jae Young ^d   Babiuk, Shawn ^b,c   Zhou, Yan ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c CANADIAN FOOD INSPECTION AGENCY   (Canada)

^d Animal Plant and Fisheries Quarantine and Inspection Agency   (South Korea)

Author keywords

Pig model; Swine infleunza virus; Vaccine; Virus like particles

Indexed keywords

HA PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; NA PROTEIN; PROTEIN M1; UNCLASSIFIED DRUG; VIRUS LIKE PARTICLE VACCINE; VIRUS PROTEIN;

2009 H1N1 INFLUENZA; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; IMMUNE RESPONSE; IMMUNITY; IMMUNOGENICITY; LUNG LESION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SWINE; VACCINATION; VIRUS LIKE AGENT; VIRUS REPLICATION; VIRUS SHEDDING;

ANIMALS; ANTIBODIES, VIRAL; HEMAGGLUTININS, VIRAL; HUMANS; IMMUNOGLOBULIN A; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; NEURAMINIDASE; ORTHOMYXOVIRIDAE INFECTIONS; PANDEMICS; SWINE; SWINE DISEASES; VACCINATION; VACCINES, VIRUS-LIKE PARTICLE; VIRAL MATRIX PROTEINS;

EID: 84862799416     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.12.083     Document Type: Article

References (31)

1. Palese P., Shaw M.L. Orthomyxoviridae: the viruses and the replication. Fields virology 2006, 1647-1677. Lippincott Williams & Wilkins, Philadelphia. 5th ed. D.M. Knipe, P.M. Howley (Eds.).
2. Ito T., Couceiro J.N., Kelm S., Baum L.G., Krauss S., Castrucci M.R., et al. Molecular basis for the generation in pigs of influenza A viruses with pandemic potential. J Virol 1998, 72:7367-7373.
3. Shope R.E. Swine influenza: III. Filtration experiments and etiology. J Exp Med 1931, 54:373-385.
4. Taubenberger J.K., Reid A.H., Lourens R.M., Wang R., Jin G., Fanning T.G. Characterization of the 1918 influenza virus polymerase genes. Nature 2005, 437:889-893.
5. Olsen C.W. The emergence of novel swine influenza viruses in North America. Virus Res 2002, 85:199-210.
6. Zhou N.N., Senne D.A., Landgraf J.S., Swenson S.L., Erickson G., Rossow K., et al. Genetic reassortment of avian, swine, and human influenza A viruses in American pigs. J Virol 1999, 73:8851-8856.
7. Vincent A.L., Ma W., Lager K.M., Janke B.H., Richt J.A. Swine influenza viruses a North American perspective. Adv Virus Res 2008, 72:127-154.
8. Neumann G., Noda T., Kawaoka Y. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 2009, 459:931-939.
9. Pereda A., Cappuccio J., Quiroga M.A., Baumeister E., Insarralde L., Ibar M., et al. Pandemic (H1N1) 2009 outbreak on pig farm, Argentina. Emerg Infect Dis 2010, 16:304-307.
10. Howden K.J., Brockhoff E.J., Caya F.D., McLeod L.J., Lavoie M., Ing J.D., et al. An investigation into human pandemic influenza virus (H1N1) 2009 on an Alberta swine farm. Can Vet J 2009, 50:1153-1161.
11. Nfon C.K., Berhane Y., Hisanaga T., Zhang S., Handel K., Kehler H., et al. Characterization of H1N1 swine influenza viruses circulating in Canadian pigs in 2009. J Virol 2011, 85:8667-8679.
12. Kang S.M., Pushko P., Bright R.A., Smith G., Compans R.W. Influenza virus-like particles as pandemic vaccines. Curr Top Microbiol Immunol 2009, 333:269-289.
13. Quan F.S., Huang C., Compans R.W., Kang S.M. Virus-like particle vaccine induces protective immunity against homologous and heterologous strains of influenza virus. J Virol 2007, 81:3514-3524.
14. Latham T., Galarza J.M. Formation of wild-type and chimeric influenza virus-like particles following simultaneous expression of only four structural proteins. J Virol 2001, 75:6154-6165.
15. Bright R.A., Carter D.M., Daniluk S., Toapanta F.R., Ahmad A., Gavrilov V., et al. Influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin. Vaccine 2007, 25:3871-3878.
16. Chen B.J., Leser G.P., Morita E., Lamb R.A. Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles. J Virol 2007, 81:7111-7123.
17. Mahmood K., Bright R.A., Mytle N., Carter D.M., Crevar C.J., Achenbach J.E., et al. H5N1 VLP vaccine induced protection in ferrets against lethal challenge with highly pathogenic H5N1 influenza viruses. Vaccine 2008, 26:5393-5399.
18. Bright R.A., Carter D.M., Crevar C.J., Toapanta F.R., Steckbeck J.D., Cole K.S., et al. Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle. PLoS One 2008, 3:e1501.
19. Pushko P., Tumpey T.M., Bu F., Knell J., Robinson R., Smith G. Influenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice. Vaccine 2005, 23:5751-5759.
20. Matassov D., Cupo A., Galarza J.M. A novel intranasal virus-like particle (VLP) vaccine designed to protect against the pandemic 1918 influenza A virus (H1N1). Viral Immunol 2007, 20:441-452.
21. Krammer F., Nakowitsch S., Messner P., Palmberger D., Ferko B., Grabherr R. Swine-origin pandemic H1N1 influenza virus-like particles produced in insect cells induce hemagglutination inhibiting antibodies in BALB/c mice. Biotechnol J 2010, 5:17-23.
22. Pushko P., Kort T., Nathan M., Pearce M.B., Smith G., Tumpey T.M. Recombinant H1N1 virus-like particle vaccine elicits protective immunity in ferrets against the 2009 pandemic H1N1 influenza virus. Vaccine 2010, 28:4771-4776.
23. Quan F.S., Vunnava A., Compans R.W., Kang S.M. Virus-like particle vaccine protects against 2009 H1N1 pandemic influenza virus in mice. PLoS One 2010, 5:e9161.
24. Masic A., Babiuk L.A., Zhou Y. Reverse genetics-generated elastase-dependent swine influenza viruses are attenuated in pigs. J Gen Virol 2009, 90:375-385.
25. Shin Y.K., Liu Q., Tikoo S.K., Babiuk L.A., Zhou Y. Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation. J Gen Virol 2007, 88:942-950.
26. Babiuk S., Masic A., Graham J., Neufeld J., van der Loop M., Copps J., et al. An elastase-dependent attenuated heterologous swine influenza virus protects against pandemic H1N1 2009 influenza challenge in swine. Vaccine 2011, 29:3118-3123.
27. Masic A., Booth J.S., Mutwiri G.K., Babiuk L.A., Zhou Y. Elastase-dependent live attenuated swine influenza A viruses are immunogenic and confer protection against swine influenza A virus infection in pigs. J Virol 2009, 83:10198-10210.
28. Masic A., Lu X., Li J., Mutwiri G.K., Babiuk L.A., Brown E.G., et al. Immunogenicity and protective efficacy of an elastase-dependent live attenuated swine influenza virus vaccine administered intranasally in pigs. Vaccine 2010, 28:7098-7108.
29. Itoh Y., Shinya K., Kiso M., Watanabe T., Sakoda Y., Hatta M., et al. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 2009, 460:1021-1025.
30. Vincent A.L., Ciacci-Zanella J.R., Lorusso A., Gauger P.C., Zanella E.L., Kehrli M.E., et al. Efficacy of inactivated swine influenza virus vaccines against the 2009 A/H1N1 influenza virus in pigs. Vaccine 2010, 28:2782-2787.
31. Quan F.S., Yoo D.G., Song J.M., Clements J.D., Compans R.W., Kang S.M. Kinetics of immune responses to influenza virus-like particles and dose-dependence of protection with a single vaccination. J Virol 2009, 83:4489-4497.