Autophagy prior to chondrocyte cell death during the degeneration of Meckel's cartilage

Anatomical Record

Volumn 295, Issue 5, 2012, Pages 734-741

  Yang, Rong Tao ^a   Zhang, Chi ^a   Liu, Yong ^a   Zhou, Hai Hua ^a   Li, Zu Bing ^a,b  

^a Wuhan University   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Cell death; Chondrocytes; Meckel's cartilage

Indexed keywords

BECLIN 1; CASPASE 3; E17 PROTEIN; LC3 PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CARTILAGE CELL; CARTILAGE DEGENERATION; EMBRYO; FEMALE; HISTOPATHOLOGY; HYALINE CARTILAGE; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MECKEL CARTILAGE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CARTILAGE; CASPASE 3; CHONDROCYTES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, INBRED BALB C; MICROTUBULE-ASSOCIATED PROTEINS; PROTO-ONCOGENE PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

MUS;

EID: 84862798886     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.22433     Document Type: Article

References (28)

1. Amano O, Doi T, Yamada T, Sasaki A, Sakiyama K, Kanegae H, Kindaichi K. 2010. Meckel's cartilage:discovery, embryology and evolution. J Oral Biosci 52: 125-135.
2. Bhaskar SN, Weinmann JP, Schour I. 1953. Role of Meckel's cartilage in the development and growth of the rat mandible. J Dent Res 32: 398-410.
3. Bohensky J, Shapiro IM, Leshinsky S, Terkhorn SP, Adams CS, Srinivas V. 2007. HIF-1 regulation of chondrocyte apoptosis: induction of the autophagic pathway. Autophagy 3: 207-214.
4. Caramés B, Taniguchi N, Otsuki S, Blanco FJ, Lotz M. 2010. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum 62: 791-801.
5. Emons J, Chagin AS, Hultenby K, Zhivotovsky B, Wit JM, Karperien M, Savendahl L. 2009. Epiphyseal fusion in the human growth plate does not involve classical apoptosis. Pediatr Res 66: 654-659.
6. Emons J, Chagin AS, Savendahl L, Karperien M, Wit JM. 2011. Mechanisms of growth plate maturation and epiphyseal fusion. Horm Res Paediatr 75: 383-391.
7. Ishizeki K, Takahashi N, Nawa T. 2001. Formation of the sphenomandibular ligament by Meckel's cartilage in the mouse: possible involvement of epidermal growth factor as revealed by studies in vivo and in vitro. Cell Tissue Res 304: 67-80.
8. Ishizeki K, Takigawa M, Harada Y, Suzuki F, Nawa T. 1996a. Meckel's cartilage chondrocytes in organ culture synthesize bone-type proteins accompanying osteocytic phenotype expression. Anat Embryol (Berl) 193: 61-71.
9. Ishizeki K, Takigawa M, Nawa T, Suzuki F. 1996b. Mouse Meckel's cartilage chondrocytes evoke bone-like matrix and further transform into osteocyte-like cells in culture. Anat Rec 245: 25-35.
10. Lee SK, Kim YS, Oh HS, Yang KH, Kim EC, Chi JG. 2001. Prenatal development of the human mandible. Anat Rec 263: 314-325.
11. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M. 2008. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol 40: 46-62.
12. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. 2007. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752.
13. Mizushima N. 2007. Autophagy: process and function. Genes Dev 21: 2861-2873.
14. Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45.
15. Portt L, Norman G, Clapp C, Greenwood M, Greenwood MT. 2011. Anti-apoptosis and cell survival: a review. Biochim Biophys Acta 1813: 238-259.
16. Roach HI, Aigner T, Kouri JB. 2004. Chondroptosis: a variant of apoptotic cell death in chondrocytes? Apoptosis 9: 265-277.
17. Roach HI, Clarke NM. 1999. "Cell paralysis" as an intermediate stage in the programmed cell death of epiphyseal chondrocytes during development. J Bone Miner Res 14: 1367-1378.
18. Rodriguez-Vazquez JF, Merida-Velasco JR, Merida-Velasco JA, Sanchez-Montesinos I, Espin-Ferra J, Jimenez-Collado J. 1997. Development of Meckel's cartilage in the symphyseal region in man. Anat Rec 249: 249-254.
19. Rutledge RG. 2004. Sigmoidal curve-fitting redefines quantitative real-time PCR with the prospective of developing automated high-throughput applications. Nucleic Acids Res 32: e178.
20. Sakakura Y, Hosokawa Y, Tsuruga E, Irie K, Nakamura M, Yajima T. 2007. Contributions of matrix metalloproteinases toward Meckel's cartilage resorption in mice: immunohistochemical studies, including comparisons with developing endochondral bones. Cell Tissue Res 328: 137-151.
21. Sakakura Y, Tsuruga E, Irie K, Hosokawa Y, Nakamura H, Yajima T. 2005. Immunolocalization of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG) in Meckel's cartilage compared with developing endochondral bones in mice. J Anat 207: 325-337.
22. Shapiro I, Adams C, Srinivas V, Freeman T. 2008. Chondrocyte hypertrophy and apoptosis at the cartilage-bone interface. In: Bronner F, Farach-Carson MC, editors. Bone and osteoarthritis. London: Springer. p 109-129.
23. Shapiro IM, Adams CS, Freeman T, Srinivas V. 2005. Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. Birth Defects Res C Embryo Today 75: 330-339.
24. Shapiro IM, Srinivas V. 2007. Metabolic consideration of epiphyseal growth: survival responses in a taxing environment. Bone 40: 561-567.
25. Shimo T, Kanyama M, Wu C, Sugito H, Billings PC, Abrams WR, Rosenbloom J, Iwamoto M, Pacifici M, Koyama E. 2004. Expression and roles of connective tissue growth factor in Meckel's cartilage development. Dev Dyn 231: 136-147.
26. Srinivas V, Bohensky J, Shapiro IM. 2009. Autophagy: a new phase in the maturation of growth plate chondrocytes is regulated by HIF, mTOR and AMP kinase. Cells Tissues Organs 189: 88-92.
27. Tomo S, Ogita M, Tomo I. 1997. Development of mandibular cartilages in the rat. Anat Rec 249: 233-239.
28. van den Berg WB. 2011. Osteoarthritis year 2010 in review: pathomechanisms. Osteoarthritis Cartilage 19: 338-341.