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Volumn 75, Issue 6, 2011, Pages 383-391

Mechanisms of growth plate maturation and epiphyseal fusion

Author keywords

Cartilage disorder; Epiphyseal fusion; Growth disorder; Growth plate maturation

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GROWTH FACTOR; GROWTH HORMONE; HORMONE; SEX HORMONE; SOMATOMEDIN C; STERYL SULFATASE; TESTOSTERONE 17BETA DEHYDROGENASE;

EID: 79957960715     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000327788     Document Type: Review
Times cited : (78)

References (79)
  • 1
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • DOI 10.1038/nature01657
    • Kronenberg HM: Developmental regulation of the growth plate. Nature 2003; 423: 332-336. (Pubitemid 40852707)
    • (2003) Nature , vol.423 , Issue.6937 , pp. 332-336
    • Kronenberg, H.M.1
  • 3
    • 0036192519 scopus 로고    scopus 로고
    • Expression of estrogen receptor α and β in the epiphyseal plate of the rat
    • DOI 10.1016/S8756-3282(01)00703-7, PII S8756328201007037
    • van der Eerden BC, Gevers EF, Lowik CW, Karperien M, Wit JM: Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat. Bone 2002; 30: 478-485. (Pubitemid 34204122)
    • (2002) Bone , vol.30 , Issue.3 , pp. 478-485
    • Van Der Eerden, B.C.J.1    Gevers, E.F.2    Lowik, C.W.G.M.3    Karperien, M.4    Wit, J.M.5
  • 4
    • 0033950445 scopus 로고    scopus 로고
    • Indian Hedgehog coordinates endochondral bone growth and morphogenesis via Parathyroid Hormone related-Protein-dependent and -independent pathways
    • Karp SJ, Schipani E, St-Jacques B, Hunzelman J, Kronenberg H, McMahon AP: Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development 2000; 127: 543-548. (Pubitemid 30093402)
    • (2000) Development , vol.127 , Issue.3 , pp. 543-548
    • Karp, S.J.1    Schipani, E.2    St-Jacques, B.3    Hunzelman, J.4    Kronenberg, H.5    McMahon, A.P.6
  • 5
    • 0034078012 scopus 로고    scopus 로고
    • Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: Evidence for a locally acting growth restraining feedback loop after birth
    • van der Eerden BC, Karperien M, Gevers EF, Lowik CW, Wit JM: Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: Evidence for a locally acting growth restraining feedback loop after birth. J Bone Miner Res 2000; 15: 1045-1055. (Pubitemid 30350067)
    • (2000) Journal of Bone and Mineral Research , vol.15 , Issue.6 , pp. 1045-1055
    • Van Der Eerden, B.C.J.1    Karperien, M.2    Gevers, E.F.3    Lowik, C.W.G.M.4    Wit, J.M.5
  • 6
    • 0036686233 scopus 로고    scopus 로고
    • Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development
    • Kindblom JM, Nilsson O, Hurme T, Ohlsson C, Savendahl L: Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development. J Endocrinol 2002; 174:R1-R6. (Pubitemid 34965776)
    • (2002) Journal of Endocrinology , vol.174 , Issue.2
    • Kindblom, J.M.1    Nilsson, O.2    Hurme, T.3    Ohlsson, C.4    Savendahl, L.5
  • 7
    • 78651087393 scopus 로고    scopus 로고
    • Parathyroid hormone/ parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life
    • Hirai T, Chagin AS, Kobayashi T, Mackem S, Kronenberg HM: Parathyroid hormone/ parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life. Proc Natl Acad Sci USA 2011; 108: 191-196.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 191-196
    • Hirai, T.1    Chagin, A.S.2    Kobayashi, T.3    Mackem, S.4    Kronenberg, H.M.5
  • 8
    • 0037383555 scopus 로고    scopus 로고
    • Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips
    • DOI 10.1086/374318
    • Hellemans J, Coucke PJ, Giedion A, De Paepe A, Kramer P, Beemer F, Mortier GR: Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips. Am J Hum Genet 2003; 72: 1040-1046. (Pubitemid 36403324)
    • (2003) American Journal of Human Genetics , vol.72 , Issue.4 , pp. 1040-1046
    • Hellemans, J.1    Coucke, P.J.2    Giedion, A.3    De Paepe, A.4    Kramer, P.5    Beemer, F.6    Mortier, G.R.7
  • 10
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    • DOI 10.1038/383407a0
    • Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA: Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 1996; 383: 407-413. (Pubitemid 26330823)
    • (1996) Nature , vol.383 , Issue.6599 , pp. 407-413
    • Chiang, C.1    Litingtung, Y.2    Lee, E.3    Young, K.E.4    Corden, J.L.5    Westphal, H.6    Beachy, P.A.7
  • 12
    • 0031442990 scopus 로고    scopus 로고
    • Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide
    • Schipani E, Lanske B, Hunzelman J, Luz A, Kovacs CS, Lee K, Pirro A, Kronenberg HM, Juppner H: Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Natl Acad Sci USA 1997; 94: 13689-13694.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13689-13694
    • Schipani, E.1    Lanske, B.2    Hunzelman, J.3    Luz, A.4    Kovacs, C.S.5    Lee, K.6    Pirro, A.7    Kronenberg, H.M.8    Juppner, H.9
  • 17
    • 0027209267 scopus 로고
    • TGF-β1 prevents hypertrophy of epiphyseal chondrocytes: Regulation of gene expression for cartilage matrix proteins and metalloproteases
    • DOI 10.1006/dbio.1993.1200
    • Ballock RT, Heydemann A, Wakefield LM, Flanders KC, Roberts AB, Sporn MB: TGFbeta 1 prevents hypertrophy of epiphyseal chondrocytes: Regulation of gene expression for cartilage matrix proteins and metalloproteases. Dev Biol 1993; 158: 414-429. (Pubitemid 23243899)
    • (1993) Developmental Biology , vol.158 , Issue.2 , pp. 414-429
    • Ballock, R.T.1    Heydemann, A.2    Wakefield, L.M.3    Flanders, K.C.4    Roberts, A.B.5    Sporn, M.B.6
  • 18
    • 77949528988 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in the growth plate is stimulated by estradiol and increases during pubertal development
    • Emons J, Chagin AS, Malmlof T, Lekman M, Tivesten A, Ohlsson C, Wit JM, Karperien M, Savendahl L: Expression of vascular endothelial growth factor in the growth plate is stimulated by estradiol and increases during pubertal development. J Endocrinol 2010; 205: 61-68.
    • (2010) J Endocrinol , vol.205 , pp. 61-68
    • Emons, J.1    Chagin, A.S.2    Malmlof, T.3    Lekman, M.4    Tivesten, A.5    Ohlsson, C.6    Wit, J.M.7    Karperien, M.8    Savendahl, L.9
  • 20
    • 0034743566 scopus 로고    scopus 로고
    • 3 on metalloproteinase activity and cell maturation in growth plate cartilage in vivo
    • DOI 10.1385/ENDO:14:3:311
    • Dean DD, Boyan BD, Schwart Z, Muniz OE, Carreno MR, Maeda S, Howell DS: Effect of 1alpha,25-dihydroxyvitamin D 3 and 24R,25-dihydroxyvitamin D 3 on metalloproteinase activity and cell maturation in growth plate cartilage in vivo. Endocrine 2001; 14: 311-323. (Pubitemid 32547813)
    • (2001) Endocrine , vol.14 , Issue.3 , pp. 311-323
    • Dean, D.D.1    Boyan, B.D.2    Schwartz, Z.3    Muniz, O.E.4    Carreno, M.R.5    Maeda, S.6    Howell, D.S.7
  • 21
    • 0036720621 scopus 로고    scopus 로고
    • Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytes
    • DOI 10.1210/en.2002-220454
    • Donohue MM, Demay MB: Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytes. Endocrinology 2002; 143: 3691-3694. (Pubitemid 34925746)
    • (2002) Endocrinology , vol.143 , Issue.9 , pp. 3691-3694
    • Donohue, M.M.1    Demay, M.B.2
  • 22
    • 0036074043 scopus 로고    scopus 로고
    • 3involves cell-maturation-specific membrane-receptor-activated phospholipid metabolism
    • Boyan BD, Sylvia VL, Dean DD, Del Toro F, Schwartz Z: Differential regulation of growth plate chondrocytes by 1alpha,25-(OH)2D3 and 24R,25-(OH)2D3 involves cell-maturation-specific membrane-receptor-activated phospholipid metabolism. Crit Rev Oral Biol Med 2002; 13: 143-154. (Pubitemid 34791215)
    • (2002) Critical Reviews in Oral Biology and Medicine , vol.13 , Issue.2 , pp. 143-154
    • Boyan, B.D.1    Sylvia, V.L.2    Dean, D.D.3    Del Toro, F.4    Schwartz, Z.5
  • 23
    • 0035543988 scopus 로고    scopus 로고
    • 3 24R-hydroxylase activity in growth zone costochondral growth plate chondrocytes via protein kinase C
    • DOI 10.1007/s00223-001-1009-y
    • Schwartz Z, Pedrozo HA, Sylvia VL, Gomez R, Dean DD, Boyan BD: 1alpha,25-(OH)2D3 regulates 25-hydroxyvitamin D 3 24R-hydroxylase activity in growth zone costochondral growth plate chondrocytes via protein kinase C. Calcif Tissue Int 2001; 69: 365-372. (Pubitemid 34056800)
    • (2001) Calcified Tissue International , vol.69 , Issue.6 , pp. 365-372
    • Schwartz, Z.1    Pedrozo, H.A.2    Sylvia, V.L.3    Gomez, R.4    Dean, D.D.5    Boyan, B.D.6
  • 25
    • 0028074798 scopus 로고
    • 3 on proliferation and vitamin D receptor expression of rat growth cartilage cells
    • DOI 10.1210/en.135.4.1307
    • Klaus G, von EB, May T, Hugel U, Mayer H, Ritz E, Mehls O: Synergistic effects of parathyroid hormone and 1,25-dihydroxyvitamin D 3 on proliferation and vitamin D receptor expression of rat growth cartilage cells. Endocrinology 1994; 135: 1307-1315. (Pubitemid 24307503)
    • (1994) Endocrinology , vol.135 , Issue.4 , pp. 1307-1315
    • Klaus, G.1    Eichel, B.V.2    May, T.3    Hugel, U.4    Mayer, H.5    Ritz, E.6    Mehls, O.7
  • 26
    • 34247348274 scopus 로고    scopus 로고
    • Gradients in bone morphogenetic protein-related gene expression across the growth plate
    • DOI 10.1677/joe.1.07099
    • Nilsson O, Parker EA, Hegde A, Chau M, Barnes KM, Baron J: Gradients in bone morphogenetic protein-related gene expression across the growth plate. J Endocrinol 2007; 193: 75-84. (Pubitemid 46638534)
    • (2007) Journal of Endocrinology , vol.193 , Issue.1 , pp. 75-84
    • Nilsson, O.1    Parker, E.A.2    Hegde, A.3    Chau, M.4    Barnes, K.M.5    Baron, J.6
  • 27
    • 0034643084 scopus 로고    scopus 로고
    • BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes
    • DOI 10.1006/dbio.2000.9610
    • Pizette S, Niswander L: BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes. Dev Biol 2000; 219: 237-249. (Pubitemid 30152602)
    • (2000) Developmental Biology , vol.219 , Issue.2 , pp. 237-249
    • Pizette, S.1    Niswander, L.2
  • 28
    • 0034747252 scopus 로고    scopus 로고
    • BMP and lhh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina E, Wenzel HM, Kreschel C, Karp S, Gaffield W, McMahon AP, Vortkamp A: BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 2001; 128: 4523-4534. (Pubitemid 33130432)
    • (2001) Development , vol.128 , Issue.22 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6    Vortkamp, A.7
  • 29
    • 22244439199 scopus 로고    scopus 로고
    • Wnt influence on chondrocyte differentiation and cartilage function
    • DOI 10.1089/dna.2005.24.446
    • Yates KE, Shortkroff S, Reish RG: Wnt influence on chondrocyte differentiation and cartilage function. DNA Cell Biol 2005; 24: 446-457. (Pubitemid 40994556)
    • (2005) DNA and Cell Biology , vol.24 , Issue.7 , pp. 446-457
    • Yates, K.E.1    Shortkroff, S.2    Reish, R.G.3
  • 30
    • 0033035607 scopus 로고    scopus 로고
    • Delta-1 negatively regulates the transition from prehypertrophic to hypertrophic chondrocytes during cartilage formation
    • Crowe R, Zikherman J, Niswander L: Delta-1 negatively regulates the transition from prehypertrophic to hypertrophic chondrocytes during cartilage formation. Development 1999; 126: 987-998. (Pubitemid 29142006)
    • (1999) Development , vol.126 , Issue.5 , pp. 987-998
    • Crowe, R.1    Zikherman, J.2    Niswander, L.3
  • 31
    • 0036744820 scopus 로고    scopus 로고
    • Interaction of FGF, Ihh/ Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation
    • Minina E, Kreschel C, Naski MC, Ornitz DM, Vortkamp A: Interaction of FGF, Ihh/ Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev Cell 2002; 3: 439-449.
    • (2002) Dev Cell , vol.3 , pp. 439-449
    • Minina, E.1    Kreschel, C.2    Naski, M.C.3    Ornitz, D.M.4    Vortkamp, A.5
  • 32
    • 33846566729 scopus 로고    scopus 로고
    • Fibroblast growth factor expression in the postnatal growth plate
    • DOI 10.1016/j.bone.2006.10.013, PII S8756328206007897
    • Lazarus JE, Hegde A, Andrade AC, Nilsson O, Baron J: Fibroblast growth factor expression in the postnatal growth plate. Bone 2007; 40: 577-586. (Pubitemid 46187233)
    • (2007) Bone , vol.40 , Issue.3 , pp. 577-586
    • Lazarus, J.E.1    Hegde, A.2    Andrade, A.C.3    Nilsson, O.4    Baron, J.5
  • 33
    • 0027964261 scopus 로고
    • Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
    • DOI 10.1016/0092-8674(94)90302-6
    • Shiang R, Thompson LM, Zhu YZ, Church DM, Fielder TJ, Bocian M, Winokur ST, Wasmuth JJ: Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 1994; 78: 335-342. (Pubitemid 24241100)
    • (1994) Cell , vol.78 , Issue.2 , pp. 335-342
    • Shiang, R.1    Thompson, L.M.2    Zhu, Y.-Z.3    Church, D.M.4    Fielder, T.J.5    Bocian, M.6    Winokur, S.T.7    Wasmuth, J.J.8
  • 40
    • 36849079376 scopus 로고    scopus 로고
    • Brief report: GPR30 estrogen receptor expression in the growth plate declines as puberty progresses
    • DOI 10.1210/jc.2007-0814
    • Chagin AS, Savendahl L: GPR30 estrogen receptor expression in the growth plate declines as puberty progresses. J Clin Endocrinol Metab 2007; 92: 4873-4877. (Pubitemid 350223471)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , Issue.12 , pp. 4873-4877
    • Chagin, A.S.1    Savendahl, L.2
  • 43
    • 1842582910 scopus 로고    scopus 로고
    • Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation
    • DOI 10.1677/joe.0.1800457
    • van der Eerden BC, Lowik CW, Wit JM, Karperien M: Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation. J Endocrinol 2004; 180: 457-467. (Pubitemid 38443398)
    • (2004) Journal of Endocrinology , vol.180 , Issue.3 , pp. 457-467
    • Van Der Eerden, B.C.J.1    Lowik, C.W.G.M.2    Wit, J.M.3    Karperien, M.4
  • 45
    • 0038476031 scopus 로고    scopus 로고
    • Localization of estrogen receptors-α and -β and androgen receptor in the human growth plate at different pubertal stages
    • DOI 10.1677/joe.0.1770319
    • Nilsson O, Chrysis D, Pajulo O, Boman A, Holst M, Rubinstein J, Martin RE, Savendahl L: Localization of estrogen receptors-alpha and -beta and androgen receptor in the human growth plate at different pubertal stages. J Endocrinol 2003; 177: 319-326. (Pubitemid 36656405)
    • (2003) Journal of Endocrinology , vol.177 , Issue.2 , pp. 319-326
    • Nilsson, O.1    Chrysis, D.2    Pajulo, O.3    Boman, A.4    Holst, M.5    Rubinstein, J.6    Ritzen, E.M.7    Savendahl, L.8
  • 46
    • 0024378370 scopus 로고
    • Direct administration of testosterone increases rat tibial epiphyseal growth plate width
    • Ren SG, Malozowski S, Sanchez P, Sweet DE, Loriaux DL, Cassorla F: Direct administration of testosterone increases rat tibial epiphyseal growth plate width. Acta Endocrinol (Copenh) 1989; 121: 401-405. (Pubitemid 19224916)
    • (1989) Acta Endocrinologica , vol.121 , Issue.3 , pp. 401-405
    • Ren, S.G.1    Malozowski, S.2    Sanchez, P.3    Seet, D.E.4    Loriaux, D.L.5    Cassorla, F.6
  • 47
    • 0027417528 scopus 로고
    • Androgen-stimulated pubertal growth: The effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty
    • DOI 10.1210/jc.76.4.996
    • Keenan BS, Richards GE, Ponder SW, Dallas JS, Nagamani M, Smith ER: Androgen-stimulated pubertal growth: The effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty. J Clin Endocrinol Metab 1993; 76: 996-1001. (Pubitemid 23110851)
    • (1993) Journal of Clinical Endocrinology and Metabolism , vol.76 , Issue.4 , pp. 996-1001
    • Keenan, B.S.1    Richards, G.E.2    Ponder, S.W.3    Dallas, J.S.4    Nagamani, M.5    Smith, E.R.6
  • 48
    • 0032586720 scopus 로고    scopus 로고
    • Testosterone stimulatesinsulin-like growth factor-I and insulin-like growth factor-I-receptor gene expression in the mandibular condyle - A model of endochondral ossification
    • Maor G, Segev Y, Phillip M: Testosterone stimulates insulin-like growth factor-I and insulin-like growth factor-I-receptor gene expression in the mandibular condyle -a model of endochondral ossification. Endocrinology 1999; 140: 1901-1910. (Pubitemid 29149264)
    • (1999) Endocrinology , vol.140 , Issue.4 , pp. 1901-1910
    • Maor, G.1    Segev, Y.2    Phillip, M.3
  • 50
    • 0029023833 scopus 로고
    • Steroid regulation of parathyroid hormone-related protein expression and action in the rat uterus
    • Paspaliaris V, Petersen DN, Thiede MA: Steroid regulation of parathyroid hormone-related protein expression and action in the rat uterus. J Steroid Biochem Mol Biol 1995; 53: 259-265.
    • (1995) J Steroid Biochem Mol Biol , vol.53 , pp. 259-265
    • Paspaliaris, V.1    Petersen, D.N.2    Thiede, M.A.3
  • 51
    • 57349179195 scopus 로고    scopus 로고
    • Estradiol supplementation in postmenopausal women attenuates suppression of pulsatile growth hormone secretion by recombinant human insulin-like growth factor type I
    • DOI 10.1210/jc.2008-1493
    • Veldhuis JD, Keenan DM, Bailey JN, Adeniji A, Miles JM, Paulo R, Cosma M, Soares-Welch C: Estradiol supplementation in postmenopausal women attenuates suppression of pulsatile growth hormone secretion by recombinant human insulin-like growth factor type I. J Clin Endocrinol Metab 2008; 93: 4471-4478. (Pubitemid 352789549)
    • (2008) Journal of Clinical Endocrinology and Metabolism , vol.93 , Issue.11 , pp. 4471-4478
    • Veldhuis, J.D.1    Keenan, D.M.2    Bailey, J.N.3    Adeniji, A.4    Miles, J.M.5    Paulo, R.6    Cosma, M.7    Soares-Welch, C.8
  • 52
    • 36949033137 scopus 로고    scopus 로고
    • The role of sex steroids in controlling pubertal growth
    • DOI 10.1111/j.1365-2265.2007.02960.x
    • Perry RJ, Farquharson C, Ahmed SF: The role of sex steroids in controlling pubertal growth. Clin Endocrinol (Oxf) 2008; 68: 4-15. (Pubitemid 350243472)
    • (2008) Clinical Endocrinology , vol.68 , Issue.1 , pp. 4-15
    • Perry, R.J.1    Farquharson, C.2    Ahmed, S.F.3
  • 57
    • 0032908103 scopus 로고    scopus 로고
    • Transplantation of epiphyseal plate allografts between animals of different ages
    • DOI 10.1097/00004694-199905000-00022
    • Stevens DG, Boyer MI, Bowen CV: Transplantation of epiphyseal plate allografts between animals of different ages. J Pediatr Orthop 1999; 19: 398-403. (Pubitemid 29214989)
    • (1999) Journal of Pediatric Orthopaedics , vol.19 , Issue.3 , pp. 398-403
    • Stevens, D.G.1    Boyer, M.I.2    Bowen, C.V.A.3
  • 59
    • 77957893888 scopus 로고    scopus 로고
    • Changes in gene expression associated with aging commonly originate during juvenile growth
    • Lui JC, Chen W, Barnes KM, Baron J: Changes in gene expression associated with aging commonly originate during juvenile growth. Mech Ageing Dev 2010; 131: 641-649.
    • (2010) Mech Ageing Dev , vol.131 , pp. 641-649
    • Lui, J.C.1    Chen, W.2    Barnes, K.M.3    Baron, J.4
  • 61
    • 0036830491 scopus 로고    scopus 로고
    • The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    • DOI 10.1101/gad.1017802
    • Akiyama H, Chaboissier MC, Martin JF, Schedl A, de Crombrugghe B: The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 2002; 16: 2813-2828. (Pubitemid 35253149)
    • (2002) Genes and Development , vol.16 , Issue.21 , pp. 2813-2828
    • Akiyama, H.1    Chaboissier, M.-C.2    Martin, J.F.3    Schedl, A.4    De Crombrugghe, B.5
  • 62
    • 0036669033 scopus 로고    scopus 로고
    • Apoptosis is developmentally regulated in rat growth plate
    • Chrysis D, Nilsson O, Ritzen EM, Savendahl L: Apoptosis is developmentally regulated in rat growth plate. Endocrine 2002; 18: 271-278.
    • (2002) Endocrine , vol.18 , pp. 271-278
    • Chrysis, D.1    Nilsson, O.2    Ritzen, E.M.3    Savendahl, L.4
  • 64
    • 43949175494 scopus 로고
    • Apoptosis
    • Cohen JJ: Apoptosis. Immunol Today 1993; 14: 126-130. (Pubitemid 23068297)
    • (1993) Immunology Today , vol.14 , Issue.3 , pp. 126-130
    • Cohen, J.J.1
  • 65
    • 0034068977 scopus 로고    scopus 로고
    • Physiological cell death of chondrocytes in vivo is not confined to apoptosis: New observations on the mammalian growth plate
    • Roach HI, Clarke NM: Physiological cell death of chondrocytes in vivo is not confined to apoptosis. New observations on the mammalian growth plate. J Bone Joint Surg Br 2000; 82: 601-613. (Pubitemid 30312832)
    • (2000) Journal of Bone and Joint Surgery - Series B , vol.82 , Issue.4 , pp. 601-613
    • Roach, H.I.1    Clarke, N.M.P.2
  • 67
    • 0032795657 scopus 로고    scopus 로고
    • 'Cell paralysis' as an intermediate stage in the programmed cell death of epiphyseal chondrocytes during development
    • DOI 10.1359/jbmr.1999.14.8.1367
    • Roach HI, Clarke NM: 'Cell paralysis' as an intermediate stage in the programmed cell death of epiphyseal chondrocytes during development. J Bone Miner Res 1999; 14: 1367-1378. (Pubitemid 29368299)
    • (1999) Journal of Bone and Mineral Research , vol.14 , Issue.8 , pp. 1367-1378
    • Roach, H.I.1    Clarke, N.M.P.2
  • 68
    • 0034068977 scopus 로고    scopus 로고
    • Physiological cell death of chondrocytes in vivo is not confined to apoptosis: New observations on the mammalian growth plate
    • Roach HI, Clarke NM: Physiological cell death of chondrocytes in vivo is not confined to apoptosis. New observations on the mammalian growth plate. J Bone Joint Surg Br 2000; 82: 601-613. (Pubitemid 30312832)
    • (2000) Journal of Bone and Joint Surgery - Series B , vol.82 , Issue.4 , pp. 601-613
    • Roach, H.I.1    Clarke, N.M.P.2
  • 69
    • 3142722961 scopus 로고    scopus 로고
    • Chondroptosis: A variant of apoptotic cell death in chondrocytes?
    • DOI 10.1023/B:APPT.0000025803.17498.26
    • Roach HI, Aigner T, Kouri JB: Chondroptosis: A variant of apoptotic cell death in chondrocytes? Apoptosis 2004; 9: 265-277. (Pubitemid 38981501)
    • (2004) Apoptosis , vol.9 , Issue.3 , pp. 265-277
    • Roach, H.I.1    Aigner, T.2    Kouri, J.B.3
  • 70
    • 53549132810 scopus 로고    scopus 로고
    • Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification
    • Settembre C, rteaga-Solis E, McKee MD, de PR, Al AQ, Ballabio A, Karsenty G: Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification. Genes Dev 2008; 22: 2645-2650.
    • (2008) Genes Dev , vol.22 , pp. 2645-2650
    • Settembre, C.1    Rteaga-Solis, E.2    McKee, M.D.3    De, P.R.4    Al, A.Q.5    Ballabio, A.6    Karsenty, G.7
  • 71
    • 32644441951 scopus 로고    scopus 로고
    • Fate of the hypertrophic chondrocyte: Microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate
    • DOI 10.1002/bdrc.20057
    • Shapiro IM, Adams CS, Freeman T, Srinivas V: Fate of the hypertrophic chondrocyte: Microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. Birth Defects Res C Embryo Today 2005; 75: 330-339. (Pubitemid 43244621)
    • (2005) Birth Defects Research Part C - Embryo Today: Reviews , vol.75 , Issue.4 , pp. 330-339
    • Shapiro, I.M.1    Adams, C.S.2    Freeman, T.3    Srinivas, V.4
  • 72
    • 3142722961 scopus 로고    scopus 로고
    • Chondroptosis: A variant of apoptotic cell death in chondrocytes?
    • DOI 10.1023/B:APPT.0000025803.17498.26
    • Roach HI, Aigner T, Kouri JB: Chondroptosis: A variant of apoptotic cell death in chondrocytes? Apoptosis 2004; 9: 265-277. (Pubitemid 38981501)
    • (2004) Apoptosis , vol.9 , Issue.3 , pp. 265-277
    • Roach, H.I.1    Aigner, T.2    Kouri, J.B.3
  • 73
    • 0024355481 scopus 로고
    • Bone formation following intrarenal transplantation of isolated murine chondrocytes: Chondrocyte-bone cell transdifferentiation?
    • Moskalewski S, Malejczyk J: Bone formation following intrarenal transplantation of isolated murine chondrocytes: Chondrocytebone cell transdifferentiation? Development 1989; 107: 473-480. (Pubitemid 20006087)
    • (1989) Development , vol.107 , Issue.3 , pp. 473-480
    • Moskalewski, S.1    Malejczyk, J.2
  • 75
    • 0036364515 scopus 로고    scopus 로고
    • The fate of the terminally differentiated chondrocyte: Evidence for microenvironmental regulation of chondrocyte apoptosis
    • Adams CS, Shapiro IM: The fate of the terminally differentiated chondrocyte: Evidence for microenvironmental regulation of chondrocyte apoptosis. Crit Rev Oral Biol Med 2002; 13: 465-473. (Pubitemid 36570020)
    • (2002) Critical Reviews in Oral Biology and Medicine , vol.13 , Issue.6 , pp. 465-473
    • Adams, C.S.1    Shapiro, I.M.2
  • 77
    • 50149095153 scopus 로고    scopus 로고
    • Histomorphometric analysis of an adolescent distal tibial physis prior to growth plate closure
    • White JR, Wilsman NJ, Leiferman EM, Noonan KJ: Histomorphometric analysis of an adolescent distal tibial physis prior to growth plate closure. J Child Orthop 2008; 2: 315-319.
    • (2008) J Child Orthop , vol.2 , pp. 315-319
    • White, J.R.1    Wilsman, N.J.2    Leiferman, E.M.3    Noonan, K.J.4
  • 78
    • 30344480826 scopus 로고    scopus 로고
    • Elevated expression of hypoxia inducible factor-2α in terminally differentiating growth plate chondrocytes
    • DOI 10.1002/jcp.20481
    • Stewart AJ, Houston B, Farquharson C: Elevated expression of hypoxia inducible factor-2alpha in terminally differentiating growth plate chondrocytes. J Cell Physiol 2006; 206: 435-440. (Pubitemid 43062813)
    • (2006) Journal of Cellular Physiology , vol.206 , Issue.2 , pp. 435-440
    • Stewart, A.J.1    Houston, B.2    Farquharson, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.