Sesquiterpenoids from Atractylodes macrocephala act as farnesoid X receptor and progesterone receptor modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 6, 2012, Pages 2326-2329

  Tsai, Chia Jui ^a   Liang, Jui Wei ^a   Lin, Hsiang Ru ^a  

^a NATIONAL KAOHSIUNG NORMAL UNIVERSITY   (Taiwan)

Author keywords

Atractylodes macrocephala (Asteraceae); Farnesoid X receptor; Progesterone receptor

Indexed keywords

ATRACTYLENOLIDE; CHENODEOXYCHOLIC ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR; FARNESOID X RECEPTOR MODULATOR; HORMONE RECEPTOR STIMULATING AGENT; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR MODULATOR; SESQUITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; ATRACTYLODES; ATRACTYLODES MACROCEPHALA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; TRANSACTIVATION;

ATRACTYLODES; CHOLESTEROL 7-ALPHA-HYDROXYLASE; GENES, REPORTER; HEMORRHAGE; HEP G2 CELLS; HUMANS; HYPERLIPIDEMIAS; HYPOLIPIDEMIC AGENTS; LUCIFERASES; PLANT EXTRACTS; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, PROGESTERONE; SESQUITERPENES; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

ASTERACEAE; ATRACTYLODES MACROCEPHALA;

EID: 84862798442     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.048     Document Type: Article

References (23)

1. T. Chen Curr. Opin. Chem. Biol. 12 2008 418
2. H. Gronemeyer, J.A. Gustafsson, and V. Laudet Nat. Rev. Drug Disc. 3 2004 950
3. P.D. Thompson, P. Clarkson, and R.H. Karas JAMA 289 2003 1681
4. P.C. Deedwania, and U. Javed Cardiol. Clin. 26 2008 573
5. B.M. Forman, E. Goode, J. Chen, A.E. Oro, D.J. Bradley, T. Perlmann, D.J. Noonan, L.T. Burka, T. McMorris, W.W. Lamph, R.M. Evans, and C. Weinberger Cell 81 1995 687
6. H. Tu, A.Y. Okamoto, and B. Shan Trends Cardiovasc. Med. 10 2000 30
7. B. Goodwin, S.A. Jones, R.R. Price, M.A. Watson, D.D. McKee, L.B. Moore, C. Galardi, J.G. Wilson, M.C. Lewis, M.E. Roth, P.R. Maloney, T.M. Willson, and S.A. Kliewer Mol. Cell 6 2000 517
8. W. Chen, E. Owsley, Y. Yang, D. Stroup, and J.Y.J. Chiang Lipid Res. 42 2001 1402
9. N.L. Urizar, D.H. Dowhan, and D.D. Moore J. Biol. Chem. 275 2000 39313
10. J.R. Plass, O. Mol, J. Heegsma, M. Geuken, K.N. Faber, P.L. Jansen, and M. Muller Hepatology 35 2002 589
11. T. Claudel, B. Staels, and F. Kuipers Arterioscler. Thromb. Vasc. Biol. 25 2005 2020
12. L. Dailey, D. Ambrosetti, A. Mansukhani, and C. Basilico Cytokine Growth Factor Rev. 16 2005 233
13. V. Singh, S. Kaul, R. Chander, and N.K. Kapoor Pharmacol. Res. 22 1990 37
14. N.L. Urizar, A.B. Liverman, D.T. Dodds, F.V. Silva, P. Ordentlich, Y. Yan, F.J. Gonzalez, R.A. Heyman, D.J. Mangelsdorf, and D.D. Moore Science 296 2002 1703
15. J. Cui, L. Huang, A. Zhao, J.L. Lew, J. Yu, S. Sahoo, P. Meinke, I. Royo, F. Pelaez, and S.D. Wright J. Biol. Chem. 278 2003 10214
16. O.M. Conneely, B. Mulac-Jericevic, F. DeMayo, J.P. Lydon, and B.W. O'Malley Recent Prog. Horm. Res. 57 2002 339
17. C.Q. Li, L.C. He, and Y.J. Hu Asian J. Pharmacodyn. Pharmacokinet 7 2007 283
18. F. Bohlmann, L.N. Dutta, W. Knauf, H. Robinson, and R.M. King Phytochemistry 19 1980 433
19. D. Chanda, J. Park, and H.S. Choi Endocr. J. 55 2008 253
20. S. Wang, K. Lai, F.J. Moy, A. Bhat, H.B. Hartman, and M.J. Evans Endocrinology 147 2006 4025
21. T.T. Lu, M. Makishima, J.J. Repa, K. Schoonjans, T.A. Kerr, J. Auwerx, and D.J. Mangelsdorf Mol. Cell 6 2000 507
22. J.Y. Chiang, R. Kimmel, C. Weinberger, and D. Stroup J. Biol. Chem. 275 2000 10918
23. S.P. Williams, and P.B. Sigler Nature 393 1998 392