Acute and sub-chronic toxicity studies of Danshen injection in Sprague-Dawley rats

Journal of Ethnopharmacology

Volumn 141, Issue 1, 2012, Pages 96-103

  Wang, Meng ^a   Liu, Jin ^b   Zhou, Bo ^b   Xu, Rui ^a   Tao, Li ^a   Ji, Meilin ^a   Zhu, Liping ^b   Jiang, Juan ^b   Shen, Jiao ^b   Gui, Xiaolong ^b   Gu, Leilei ^b   Bai, Wenxia ^b   Sun, Wu ^b   Cheng, Jianming ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b NANJING TECH UNIVERSITY   (China)

Author keywords

Acute toxicity; Danshen injection; Rats; Salvia miltiorrhiza Bunge; Sub chronic toxicity

Indexed keywords

HERBACEOUS AGENT; SALVIA MILTIORRHIZA EXTRACT; TRIACYLGLYCEROL;

ACUTE TOXICITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD; BODY WEIGHT; CHEMICAL ANALYSIS; CHRONIC TOXICITY; DOSE RESPONSE; DRUG SAFETY; DRUG STRUCTURE; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; INFLAMMATION; LIPID METABOLISM; MALE; MORTALITY; NONHUMAN; ORGAN WEIGHT; RAT; SALVIA MILTIORRHIZA; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; BEHAVIOR, ANIMAL; BIOLOGICAL MARKERS; BODY WEIGHT; DRUGS, CHINESE HERBAL; EATING; FEMALE; INJECTIONS, INTRAVENOUS; MALE; ORGAN SIZE; PHYTOTHERAPY; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; SALVIA MILTIORRHIZA; TIME FACTORS; TOXICITY TESTS, ACUTE; TOXICITY TESTS, SUBCHRONIC;

ANIMALIA; RATTUS; SALVIA MILTIORRHIZA;

EID: 84862797971     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.02.005     Document Type: Article

References (27)

1. K. Chan, S.H. Chui, D.Y. Wong, W.Y. Ha, C.L. Chan, and R.N. Wong Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction Life Sciences 75 2004 3157 3171
2. K.J. Chen Certain progress in the treatment of coronary heart disease with traditional medicinal plants in China American Journal of Chinese Medicine 9 1981 193 196
3. Y.C. Chen, W.W. Cao, Y. Cao, L. Zhang, B.B. Chang, W.L. Yang, and X.Q. Liu Using neural networks to determine the contribution of danshensu to its multiple cardiovascular activities in acute myocardial infarction rats Journal of Ethnopharmacology 138 2011 126 134
4. T.O. Cheng Danshen: a versatile Chinese herbal drug for the treatment of coronary heart disease International Journal of Cardiology 113 2006 437 438
5. T.O. Cheng Danshen: what every cardiologist should know about this Chinese herbal drug International Journal of Cardiology 110 2006 411 412
6. T.O. Cheng Cardiovascular effects of Danshen International Journal of Cardiology 121 2007 9 22
7. Y. Gao, Z. Liu, G. Li, C. Li, M. Li, and B. Li Acute and subchronic toxicity of danshensu in mice and rats Toxicology Mechanisms and Methods 19 2009 363 368
8. J.Y. Han, J.Y. Fan, Y. Horie, S. Miura, D.H. Cui, H. Ishii, T. Hibi, H. Tsuneki, and I. Kimura Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion Pharmacology & Therapeutics 117 2008 280 295
9. W. Ji, and B.Q. Gong Hypolipidemic activity and mechanism of purified herbal extract of Salvia miltiorrhiza in hyperlipidemic rats Journal of Ethnopharmacology 119 2008 291 298
10. X.Y. Ji, B.K. Tan, and Y.Z. Zhu Salvia miltiorrhiza and ischemic diseases Acta Pharmacologica Sinica 21 2000 1089 1094
11. D.G. Kang, Y.G. Yun, J.H. Ryoo, and H.S. Lee Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin system American Journal of Chinese Medicine 30 2002 87 93
12. Y.G. Li, L. Song, M. Liu, Z.B. Hu, and Z.T. Wang Advancement in analysis of Salviae miltiorrhizae Radix et Rhizoma (Danshen) Journal of Chromatography A 1216 2009 1941 1953
13. Q. Liu, and Z. Lu Effect of Salvia miltiorrhiza on coronary collateral circulation in dogs with experimental acute myocardial infarction Journal of Tongji Medical University 19 1999 69
14. J.B. Luo Thinking about the healthy development of traditional Chinese medicine injection Modernization of Traditional Chinese Medicine and Materia Medica 12 2010 497 501
15. S. Qian, D. Huo, S. Wang, and Q. Qian Inhibition of glucose-induced vascular endothelial growth factor expression by Salvia miltiorrhiza hydrophilic extract in human microvascular endothelial cells: evidence for mitochondrial oxidative stress Journal of Ethnopharmacology 137 2011 985 991
16. N. Ramsden, J. Perrin, Z. Ren, B.D. Lee, N. Zinn, V.L. Dawson, D. Tam, M. Bova, M. Lang, G. Drewes, M. Bantscheff, F. Bard, T.M. Dawson, and C. Hopf Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons ACS Chemical Biology 6 2011 1021 1028
17. W.Y. Tam, P. Chook, M. Qiao, L.T. Chan, T.Y. Chan, Y.K. Poon, K.P. Fung, P.C. Leung, and K.S. Woo The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients Journal of Alternative and Complementary Medicine 15 2009 415 421
18. X.H. Tian, W.J. Xue, and X.M. Ding Application of Danshen injection on early stage of renal transplantation Zhongguo Zhong Xi Yi Jie He Za Zhi 25 2005 404 407
19. X.F. Wang, and M.Q. Zhao Ligustrazine and Salvia miltiorrhiza injection solution in complementary therapy of pregnancy-induced hypertension: clinical analysis of 60 cases Di Yi Jun Yi Da Xue Xue Bao 23 2003 969 971
20. L. Wang, T. Yin, and M.W. Zhu Retrospective study of the adverse drug reaction/event Induced by Danshen injection Chinese Journal of Pharmacovigilance 6 2009 227 231
21. Z.M. Wei Effects of injection Salviae miltiorrhizae on senile chronic asthmatic bronchitis patients Zhongguo Zhong Xi Yi Jie He Za Zhi 16 1996 402 405
22. O. Xu, Y. Liu, X. Li, Y. Yang, Z. Zhang, N. Wang, Y. Zhang, and H. Lu Protective effects of Salvia miltiorrhiza against cisplatin-induced ototoxicity in guinea pigs American Journal of Otolaryngology 32 2011 228 234
23. K.K. Yue, K.W. Lee, K.K. Chan, K.S. Leung, A.W. Leung, and C.H. Cheng Danshen prevents the occurrence of oxidative stress in the eye and aorta of diabetic rats without affecting the hyperglycemic state Journal of Ethnopharmacology 106 2006 136 141
24. M. Zhang, X. Li, G. Jiu, and Y. Liu Effect of danshen injection on expression of platelet membrane glycoproteins in patients with type II diabetes mellitus Zhong Yao Cai 26 2003 738 740
25. J.L. Zhang, M. Cui, Y. He, H.L. Yu, and D.A. Guo Chemical fingerprint and metabolic fingerprint analysis of Danshen injection by HPLC-UV and HPLC-MS methods Journal of Pharmaceutical and Biomedical Analysis 36 2005 1029 1035
26. L. Zhou, Z. Zuo, and M.S. Chow Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use Journal of Clinical Pharmacology 45 2005 1345 1359
27. Y. Zhou, W. Li, L. Xu, and L. Chen In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid beta-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors Environmental Toxicology and Pharmacology 31 2011 443 452