Acute and subchronic toxicity of danshensu in mice and rats

Toxicology Mechanisms and Methods

Volumn 19, Issue 5, 2009, Pages 363-368

  Gao, Yonglin ^a,c   Liu, Zhifeng ^b,c   Li, Guisheng ^b,c   Li, Chunmei ^b,c   Li, Min ^b   Li, Bafang ^a  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b YANTAI UNIVERSITY   (China)

^c Shandong Luye Research and Development for Natural Drugs Co Ltd   (China)

Author keywords

Acute toxicity; Danshensu; Subchronic toxicity

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD EXAMINATION; BODY WEIGHT; CHRONIC TOXICITY; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG STRUCTURE; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; MALE; MORTALITY; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SERUM CHARACTERISTICS; SURVIVAL RATE;

ANIMALS; FEMALE; LACTATES; MALE; MEDICINE, CHINESE TRADITIONAL; MICE; RATS; RATS, SPRAGUE-DAWLEY;

MUS; RATTUS; SALVIA MILTIORRHIZA;

EID: 70350450974     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510902810672     Document Type: Article

References (21)

1. Chen X, Ahn DU. 1998. Antioxidant activities of six natural phenolics against lipid oxidation induced by Fe2+ or ultraviolet light. J Am Oil Chem Soc 75:1717-1721.
2. Gulcin I. 2006. Antioxidant activity of caffeic acid (3,4- dihydroxycinnamic acid). Toxicology 217:213-220.
3. Huang YS, Zhang JT. 1992. Antioxidant effect of three water-soluble components isolated from Salvia miltiorrhiza in vitro. Acta Pharmacol Sin 27:96-100.
4. Lei YQ. 2005. Determination of the content of przewatanshinquinone in Salvia Miltiorrhiza by HPLC. Guiding J TCM 11:59-61.
5. Li DY, Xu LN, Liu XG. 1995. Effects of water-soluble components isolated from Salvia miltiorrhiza on oxygen free radical generation and lipid peroxidation. J Chin Pharm Sci 4:107-112.
6. Luo XJ, Bi KS, Zhou SY, Wei QH, Zhang RH. 2001. Deternination of Danshensu, a major active compound of Radix miltionhiga in dog plasma, HPLC with fluocescence detection. Biomed Chromatogr 15:493-496.
7. Muralidhara, Narasimhamurthy K, Viswanatha S, Ramesh BS. 1999. Acute and subchronic toxicity assessment of debitterized fenugreek powder in the mouse and rat. Food Chem Toxicol 37:831-838.
8. Nakagawa K, Kitano M, Kishida H, Hidaka T, Nabae K, Kawabe M, Hosoe K. 2008. 90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats. Food Chem Toxicol 46:2349-2357.
9. Pei WJ, Zhao XF, Zhu ZM, Lin CZ, Zhao WM, Zheng XH. 2004. Study of the determination and pharmacokinetics of compound danshensu dripping pills in human serum by column switching liquid chromatogr electrospray ion trap mass spectrometry. J Chromatogr B 809:237-242.
10. Rasekh HR, Nazari P, Kamli-Nejad M, Hosseinzadeh L. 2008. Acute and subchronic oral toxicity of Galega officinalis in rats. J Ethnopharmacol 116:21-26.
11. Rhiouani H, El-Hilaly J, Israili ZH, Lyoussi B. 2008. Acute and subchronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents. J Ethnopharmacol 118:378-386.
12. Schmitt D, Tran N, Riefler S, Jacoby J, Merkel D, Marone P, Naouli N. 2008. Toxicologic evaluation of modified gum acacia: mutagenicity, acute and subchronic toxicity. Food Chem Toxicol 46:1048-1054.
13. Tianjin Talisco Pharmaceutical Group Co. Ltd. 1998. Approval of compound danshen dripping pill (DSP) by FDA through pre-IND for clinical trials. Proc Forum Int Chin Mater Med 18-30.
14. Woodman DD. 1996. Assessment of hepatotoxicity. In: Evans GO (Ed.), Animal Clinical Chemistry, A Primer for Toxicologists, Taylor & Francis, London, pp. 71-86.
15. Yang XY, Yao RM, Dai LD, Han BF. 1981. Clinical observation and pharmacological experiment study of danshensu. Chin Tradit Pat Med 2:35-37,45.
16. You J-S, Pan T-L, Lee Y-S. 2007. Protective effects of danshen (Salvia miltiorrhiza) on adriamycin-induced cardiac and hepatic toxicity in rat. Phytother Res 21:1146-1152.
17. Zhang JX, Tian JW. 2007. Safety evaluation of danshensu injection. J Toxicol 4:314.
18. Zhang T, Wang CY, Tian JW, Fu FH, Liu K. 2005. Protection of danshensu on brain damage in rats. Chin Trad Herbal Drugs 36:1041-1043.
19. Zhao BL, Jiang W, Zhao Y, Hou JW, Xin WJ. 1996. Scavenging effects of Salvia miltionrrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury. Biochem Mol Biol Int 38:1171-1182.
20. Zhao G-R, Zhang H-M, Ye T-X, Xiang Z-J, Yuan Y-J, Guo Z-X, Zhao L-B. 2008. Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B. Food Chem Toxicol 46:73-81.
21. Zhou L, Zuo Z, Chow MS. 2005. Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 45:1345-1359.