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Volumn 138, Issue 1, 2011, Pages 126-134

Using neural networks to determine the contribution of danshensu to its multiple cardiovascular activities in acute myocardial infarction rats

Author keywords

Acute myocardial infarction; Artificial neural network; Contribution; Danshensu; Pharmacodynamics; Pharmacokinetics

Indexed keywords

3 (3,4 DIHYDROXYPHENYL)LACTIC ACID; GLUTATHIONE; HOMOCYSTEINE; TROPONIN T;

EID: 80255131341     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.08.069     Document Type: Article
Times cited : (26)

References (60)
  • 1
    • 77955488611 scopus 로고    scopus 로고
    • Nonlinear process modeling of fructosyltransferase (FTase) using bootstrap re-sampling neural network model
    • Z. Ahmad, M.M. Don, S.H. Mortan, and R.A. Noor Nonlinear process modeling of fructosyltransferase (FTase) using bootstrap re-sampling neural network model Bioprocess and Biosystems Engineering 33 2010 599 606
    • (2010) Bioprocess and Biosystems Engineering , vol.33 , pp. 599-606
    • Ahmad, Z.1    Don, M.M.2    Mortan, S.H.3    Noor, R.A.4
  • 2
    • 0030061822 scopus 로고    scopus 로고
    • Prospective validation of artificial neural network trained to identify acute myocardial infarction
    • DOI 10.1016/S0140-6736(96)91555-X
    • W.G. Baxt, and J. Skora Prospective validation of artificial neural network trained to identify acute myocardial infarction Lancet 347 1996 12 15 (Pubitemid 26012410)
    • (1996) Lancet , vol.347 , Issue.8993 , pp. 12-15
    • Baxt, W.G.1    Skora, J.2
  • 3
    • 0031824697 scopus 로고    scopus 로고
    • Methodological issues in pharmacokinetic-pharmacodynamic modelling
    • DOI 10.2165/00003088-199835020-00004
    • E. Bellissant, V. Sebille, and G. Paintaud Methodological issues in pharmacokinetic-pharmacodynamic modelling Clinical Pharmacokinetics 35 1998 151 166 (Pubitemid 28379426)
    • (1998) Clinical Pharmacokinetics , vol.35 , Issue.2 , pp. 151-166
    • Bellissant, E.1    Sebille, V.2    Paintaud, G.3
  • 5
    • 67650013899 scopus 로고    scopus 로고
    • Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rats
    • Y.G. Cao, J.G. Chai, Y.C. Chen, J. Zhao, J. Zhou, J.P. Shao, C. Ma, X.D. Liu, and X.Q. Liu Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rats British Journal of Pharmacology 157 2009 482 490
    • (2009) British Journal of Pharmacology , vol.157 , pp. 482-490
    • Cao, Y.G.1    Chai, J.G.2    Chen, Y.C.3    Zhao, J.4    Zhou, J.5    Shao, J.P.6    Ma, C.7    Liu, X.D.8    Liu, X.Q.9
  • 6
    • 5444268663 scopus 로고    scopus 로고
    • Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction
    • DOI 10.1016/j.lfs.2004.06.010, PII S0024320504007581
    • K. Chan, S.H. Chui, D.Y. Wong, W.Y. Ha, C.L. Chan, and R.N. Wong Protective effects of danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction Life Sciences 75 2004 3157 3171 (Pubitemid 39361173)
    • (2004) Life Sciences , vol.75 , Issue.26 , pp. 3157-3171
    • Chan, K.1    Chui, S.H.2    Wong, D.Y.L.3    Ha, W.Y.4    Chan, C.L.5    Wong, R.N.S.6
  • 7
    • 77952029642 scopus 로고    scopus 로고
    • Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats
    • B.B. Chang, L. Zhang, W.W. Cao, Y. Cao, W.L. Yang, Y. Wang, Y.C. Chen, and X.Q. Liu Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats Acta Pharmacologica Sinica 31 2010 638 646
    • (2010) Acta Pharmacologica Sinica , vol.31 , pp. 638-646
    • Chang, B.B.1    Zhang, L.2    Cao, W.W.3    Cao, Y.4    Yang, W.L.5    Wang, Y.6    Chen, Y.C.7    Liu, X.Q.8
  • 9
    • 67650096554 scopus 로고    scopus 로고
    • Mechanism-based pharmacokinetic-pharmacodynamic modeling of bidirectional effect of danshensu on plasma homocysteine in rats
    • Y.C. Chen, Y.G. Cao, J. Zhou, and X.Q. Liu Mechanism-based pharmacokinetic-pharmacodynamic modeling of bidirectional effect of danshensu on plasma homocysteine in rats Pharmaceutical Research 26 2009 1863 1873
    • (2009) Pharmaceutical Research , vol.26 , pp. 1863-1873
    • Chen, Y.C.1    Cao, Y.G.2    Zhou, J.3    Liu, X.Q.4
  • 10
    • 0030803990 scopus 로고    scopus 로고
    • Application of neural networks to population pharmacokinetic data analysis
    • DOI 10.1021/js9604016
    • H.H. Chow, K.M. Tolle, D.J. Roe, V. Elsberry, and H. Chen Application of neural networks to population pharmacokinetic data analysis Journal of Pharmaceutical Sciences 86 1997 840 845 (Pubitemid 27297497)
    • (1997) Journal of Pharmaceutical Sciences , vol.86 , Issue.7 , pp. 840-845
    • Chow, H.-H.1    Tolle, K.M.2    Roe, D.J.3    Elsberry, V.4    Chen, H.5
  • 13
    • 0036890065 scopus 로고    scopus 로고
    • Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease
    • DOI 10.1124/pr.54.4.599
    • A. De Bree, W.M. Verschuren, D. Kromhout, L.A. Kluijtmans, and H.J. Blom Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease Pharmacological Reviews 54 2002 599 618 (Pubitemid 35351198)
    • (2002) Pharmacological Reviews , vol.54 , Issue.4 , pp. 599-618
    • De Bree, A.1    Verschuren, W.M.M.2    Kromhout, D.3    Kluijtmans, L.A.J.4    Blom, H.J.5
  • 15
    • 33845214720 scopus 로고    scopus 로고
    • Artificial neural network algorithms for early diagnosis of acute myocardial infarction and prediction of infarct size in chest pain patients
    • DOI 10.1016/j.ijcard.2005.12.019, PII S016752730600252X
    • K.M. Eggers, J. Ellenius, M. Dellborg, T. Groth, J. Oldgren, E. Swahn, and B. Lindahl Artificial neural network algorithms for early diagnosis of acute myocardial infarction and prediction of infarct size in chest pain patients International Journal of Cardiology 114 2007 366 374 (Pubitemid 44855917)
    • (2007) International Journal of Cardiology , vol.114 , Issue.3 , pp. 366-374
    • Eggers, K.M.1    Ellenius, J.2    Dellborg, M.3    Groth, T.4    Oldgren, J.5    Swahn, E.6    Lindahl, B.7
  • 16
    • 0027396025 scopus 로고
    • Introduction to backpropagation neural network computation
    • DOI 10.1023/A:1018966222807
    • R.J. Erb Introduction to backpropagation neural network computation Pharmaceutical Research 10 1993 165 170 (Pubitemid 23041727)
    • (1993) Pharmaceutical Research , vol.10 , Issue.2 , pp. 165-170
    • Erb, R.J.1
  • 17
    • 37549038706 scopus 로고    scopus 로고
    • Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning
    • P. Ferdinandy, R. Schulz, and G.F. Baxter Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning Pharmacological Reviews 59 2007 418 458
    • (2007) Pharmacological Reviews , vol.59 , pp. 418-458
    • Ferdinandy, P.1    Schulz, R.2    Baxter, G.F.3
  • 19
    • 33745946054 scopus 로고    scopus 로고
    • Feedback linearization using neural networks applied to advanced pharmacodynamic and pharmacogenomic systems
    • DOI 10.1109/IJCNN.2005.1555825, 1555825, Proceedings of the International Joint Conference on Neural Networks, IJCNN 2005
    • A. Floares Feedback linearization using neural networks applied to advanced pharmacodynamic and pharmacogenomic systems IEEE International Joint Conference on Neural Networks (IJCNN) 2005 IEEE Xplore 173 178 (Pubitemid 44055444)
    • (2005) Proceedings of the International Joint Conference on Neural Networks , vol.1 , pp. 173-178
    • Floares, A.1
  • 20
    • 0001867238 scopus 로고
    • Interpreting neural-network connection weights
    • G.D. Garson Interpreting neural-network connection weights Artificial Intelligence Expert 6 1991 46 51
    • (1991) Artificial Intelligence Expert , vol.6 , pp. 46-51
    • Garson, G.D.1
  • 21
    • 47749153759 scopus 로고    scopus 로고
    • Multiple molecular forms of circulating cardiac troponin: Analytical and clinical significance
    • DOI 10.1258/acb.2007.007229
    • D.C. Gaze, and P.O. Collinson Multiple molecular forms of circulating cardiac troponin: analytical and clinical significance Annals of Clinical Biochemistry 45 2008 349 355 (Pubitemid 352031540)
    • (2008) Annals of Clinical Biochemistry , vol.45 , Issue.4 , pp. 349-355
    • Gaze, D.C.1    Collinson, P.O.2
  • 22
    • 0037442845 scopus 로고    scopus 로고
    • Review and comparison of methods to study the contribution of variables in artificial neural network models
    • DOI 10.1016/S0304-3800(02)00257-0, PII S0304380002002570
    • M. Gevrey, I. Dimopoulos, and S. Lek Review and comparison of methods to study the contribution of variables in artificial neural network models Ecological Modelling 160 2003 249 264 (Pubitemid 36251040)
    • (2003) Ecological Modelling , vol.160 , Issue.3 , pp. 249-264
    • Gevrey, M.1    Dimopoulos, I.2    Lek, S.3
  • 23
    • 0029972428 scopus 로고    scopus 로고
    • Artificial neural networks as a novel approach to integrated pharmacokinetic-pharmacodynamic analysis
    • DOI 10.1021/js950433d
    • J.V. Gobburu, and E.P. Chen Artificial neural networks as a novel approach to integrated pharmacokinetic-pharmacodynamic analysis Journal of Pharmaceutical Sciences 85 1996 505 510 (Pubitemid 26150984)
    • (1996) Journal of Pharmaceutical Sciences , vol.85 , Issue.5 , pp. 505-510
    • Gobburu, J.V.S.1    Chen, E.P.2
  • 24
    • 0029223565 scopus 로고
    • Back-propagation neural networks for modeling complex systems
    • A.T.C. Goh Back-propagation neural networks for modeling complex systems Artificial Intelligence in Engineering 9 1995 143 151
    • (1995) Artificial Intelligence in Engineering , vol.9 , pp. 143-151
    • Goh, A.T.C.1
  • 25
    • 33846136759 scopus 로고    scopus 로고
    • Serial measurements of plasma homocysteine levels in early and late phases of ischemic stroke
    • DOI 10.1111/j.1468-1331.2006.01518.x
    • E. Haapaniemi, J. Helenius, L. Soinne, M. Syrjala, M. Kaste, and T. Tatlisumak Serial measurements of plasma homocysteine levels in early and late phases of ischemic stroke European Journal of Neurology 14 2007 12 17 (Pubitemid 46088030)
    • (2007) European Journal of Neurology , vol.14 , Issue.1 , pp. 12-17
    • Haapaniemi, E.1    Helenius, J.2    Soinne, L.3    Syrjala, M.4    Kaste, M.5    Tatlisumak, T.6
  • 26
    • 0036149005 scopus 로고    scopus 로고
    • Modeling the pharmacokinetics and pharmacodynamics of a unique oral hypoglycemic agent using neural networks
    • DOI 10.1023/A:1013611617787
    • S.H. Haidar, S.B. Johnson, M.J. Fossler, and A.S. Hussain Modeling the pharmacokinetics and pharmacodynamics of a unique oral hypoglycemic agent using neural networks Pharmaceutical Research 19 2002 87 91 (Pubitemid 34075111)
    • (2002) Pharmaceutical Research , vol.19 , Issue.1 , pp. 87-91
    • Haidar, S.H.1    Johnson, S.B.2    Fossler, M.J.3    Hussain, A.S.4
  • 27
    • 38349123913 scopus 로고    scopus 로고
    • Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion
    • J.Y. Han, J.Y. Fan, Y. Horie, S. Miura, D.H. Cui, H. Ishii, T. Hibi, H. Tsuneki, and I. Kimura Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion Pharmacology & Therapeutics 117 2008 280 295
    • (2008) Pharmacology & Therapeutics , vol.117 , pp. 280-295
    • Han, J.Y.1    Fan, J.Y.2    Horie, Y.3    Miura, S.4    Cui, D.H.5    Ishii, H.6    Hibi, T.7    Tsuneki, H.8    Kimura, I.9
  • 28
    • 2442665617 scopus 로고    scopus 로고
    • Credit rating analysis with support vector machines and neural networks: A market comparative study
    • Z. Huang, H. Chen, C.J. Hsu, W.H. Chen, and S. Wu Credit rating analysis with support vector machines and neural networks: a market comparative study Decision Support Systems 37 2004 543 558
    • (2004) Decision Support Systems , vol.37 , pp. 543-558
    • Huang, Z.1    Chen, H.2    Hsu, C.J.3    Chen, W.H.4    Wu, S.5
  • 29
    • 0037403960 scopus 로고    scopus 로고
    • Diversity of mechanism-based pharmacodynamic models
    • DOI 10.1124/dmd.31.5.510
    • D.E. Mager, E. Wyska, and W.J. Jusko Diversity of mechanism-based pharmacodynamic models Drug Metabolism and Disposition: The Biological Fate of Chemicals 31 2003 510 518 (Pubitemid 36444157)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.5 , pp. 510-518
    • Mager, D.E.1    Wyska, E.2    Jusko, W.J.3
  • 30
    • 30544446631 scopus 로고    scopus 로고
    • Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network
    • DOI 10.1002/jps.20384
    • D.E. Mager, J.D. Shirey, D. Cox, D.J. Fitzgerald, and D.R. Abernethy Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network Journal of Pharmaceutical Sciences 94 2005 2475 2486 (Pubitemid 43081944)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.11 , pp. 2475-2486
    • Mager, D.E.1    Shirey, J.D.2    Cox, D.3    Fitzgerald, D.J.4    Abernethy, D.R.5
  • 31
    • 0036144662 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic studies in drug product development
    • DOI 10.1002/jps.1167
    • B. Meibohm, and H. Derendorf Pharmacokinetic/pharmacodynamic studies in drug product development Journal of Pharmaceutical Sciences 91 2002 18 31 (Pubitemid 34074464)
    • (2002) Journal of Pharmaceutical Sciences , vol.91 , Issue.1 , pp. 18-31
    • Meibohm, B.1    Derendorf, H.2
  • 32
    • 67650921436 scopus 로고    scopus 로고
    • Artificial neural network and its application in agricultural and ecological research
    • X.C. Mi, K.P. Ma, and Y.B. Zou Artificial neural network and its application in agricultural and ecological research Acta Phytoecologica Sinica 29 2005 863 870
    • (2005) Acta Phytoecologica Sinica , vol.29 , pp. 863-870
    • Mi, X.C.1    Ma, K.P.2    Zou, Y.B.3
  • 33
    • 0034711007 scopus 로고    scopus 로고
    • The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes
    • E. Mosharov, M.R. Cranford, and R. Banerjee The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes Biochemistry 39 2000 13005 13011
    • (2000) Biochemistry , vol.39 , pp. 13005-13011
    • Mosharov, E.1    Cranford, M.R.2    Banerjee, R.3
  • 38
    • 0033019173 scopus 로고    scopus 로고
    • Prediction of pharmacokinetic parameters and the assessment of their variability in bioequivalence studies by artificial neural networks
    • DOI 10.1023/A:1018857108713
    • J. Opara, S. Primozic, and P. Cvelbar Prediction of pharmacokinetic parameters and the assessment of their variability in bioequivalence studies by artificial neural networks Pharmaceutical Research 16 1999 944 948 (Pubitemid 29284209)
    • (1999) Pharmaceutical Research , vol.16 , Issue.6 , pp. 944-948
    • Opara, J.1    Primozic, S.2    Cvelbar, P.3
  • 39
    • 39149114086 scopus 로고    scopus 로고
    • Two models of homocysteine behavior in acute myocardial infarction
    • A. Osorio, E. Ortega, and E. Ruiz-Requena Two models of homocysteine behavior in acute myocardial infarction Clinical Biochemistry 41 2008 277 281
    • (2008) Clinical Biochemistry , vol.41 , pp. 277-281
    • Osorio, A.1    Ortega, E.2    Ruiz-Requena, E.3
  • 40
    • 0029888128 scopus 로고    scopus 로고
    • Structure-antioxidant activity relationships of flavonoids and phenolic acids
    • DOI 10.1016/0891-5849(95)02227-9
    • C.A. Rice-Evans, N.J. Miller, and G. Paganga Structure-antioxidant activity relationships of flavonoids and phenolic acids Free Radical Biology and Medicine 20 1996 933 956 (Pubitemid 26157509)
    • (1996) Free Radical Biology and Medicine , vol.20 , Issue.7 , pp. 933-956
    • Rice-Evans, C.A.1    Miller, N.J.2    Paganga, G.3
  • 43
    • 4644238958 scopus 로고    scopus 로고
    • Coronary artery bypass grafting surgery is associated with a marked reduction in serum homocysteine and folate levels in the early postoperative period
    • DOI 10.1016/j.ejcts.2004.06.001, PII S1010794004004373
    • S. Storti, A.G. Cerillo, A. Rizza, I. Giannelli, G. Fontani, M. Glauber, and A. Clerico Coronary artery bypass grafting surgery is associated with a marked reduction in serum homocysteine and folate levels in the early postoperative period European Journal of Cardio-Thoracic Surgery 26 2004 682 686 (Pubitemid 39273564)
    • (2004) European Journal of Cardio-thoracic Surgery , vol.26 , Issue.4 , pp. 682-686
    • Storti, S.1    Cerillo, A.G.2    Rizza, A.3    Giannelli, I.4    Fontani, G.5    Glauber, M.6    Clerico, A.7
  • 46
    • 0027381145 scopus 로고
    • Application of neural networks to pharmacodynamics
    • DOI 10.1002/jps.2600820910
    • P. Veng-Pedersen, and N.B. Modi Application of neural networks to pharmacodynamics Journal of Pharmaceutical Sciences 82 1993 918 926 (Pubitemid 23317254)
    • (1993) Journal of Pharmaceutical Sciences , vol.82 , Issue.9 , pp. 918-926
    • Veng-Pedersen, P.1    Modi, N.B.2
  • 47
    • 33751319652 scopus 로고    scopus 로고
    • Multitarget therapy - The future of treatment for more than just functional dyspepsia
    • DOI 10.1016/j.phymed.2006.03.021, PII S0944711306000778
    • H. Wagner Multitarget therapy - the future of treatment for more than just functional dyspepsia Phytomedicine 13 Suppl. 5 2006 122 129 (Pubitemid 44816466)
    • (2006) Phytomedicine , vol.13 , Issue.SUPPL. 1 , pp. 122-129
    • Wagner, H.1
  • 48
    • 0037164375 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis
    • D.S. Wald, M. Law, and J.K. Morris Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis BMJ 325 2002 1202
    • (2002) BMJ , vol.325 , pp. 1202
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 50
    • 24344466900 scopus 로고    scopus 로고
    • Vasorelaxant and antioxidant activity of flavonols and flavones: Structure-activity relationships
    • DOI 10.1097/01.fjc.0000175431.62626.07
    • O.L. Woodman, W.F. Meeker, and M. Boujaoude Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships Journal of Cardiovascular Pharmacology 46 2005 302 309 (Pubitemid 41262832)
    • (2005) Journal of Cardiovascular Pharmacology , vol.46 , Issue.3 , pp. 302-309
    • Woodman, O.L.1    Meeker, W.F.2    Boujaoude, M.3
  • 51
    • 34548681835 scopus 로고    scopus 로고
    • Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats
    • DOI 10.1016/j.phymed.2007.07.060, PII S0944711307001845
    • L. Wu, H. Qiao, Y. Li, and L. Li Protective roles of puerarin and danshensu on acute ischemic myocardial injury in rats Phytomedicine 14 2007 652 658 (Pubitemid 47419302)
    • (2007) Phytomedicine , vol.14 , Issue.10 , pp. 652-658
    • Wu, L.1    Qiao, H.2    Li, Y.3    Li, L.4
  • 52
    • 67650786554 scopus 로고    scopus 로고
    • Effects of salvianolic acid B on the pharmacokinetics of danshensu in Danshen injection in rats
    • D. Yu, J.G. Chai, Y.G. Cao, Y.C. Chen, and X.Q. Liu Effects of salvianolic acid B on the pharmacokinetics of danshensu in Danshen injection in rats Journal of China Pharmaceutical University 40 2009 258 262
    • (2009) Journal of China Pharmaceutical University , vol.40 , pp. 258-262
    • Yu, D.1    Chai, J.G.2    Cao, Y.G.3    Chen, Y.C.4    Liu, X.Q.5
  • 55
    • 25844505550 scopus 로고    scopus 로고
    • One-compound-multiple-targets strategy to combat Alzheimer's disease
    • H.Y. Zhang One-compound-multiple-targets strategy to combat Alzheimer's disease FEBS Letters 579 2005 5260 5264
    • (2005) FEBS Letters , vol.579 , pp. 5260-5264
    • Zhang, H.Y.1
  • 58
    • 27844511101 scopus 로고    scopus 로고
    • Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
    • DOI 10.1177/0091270005282630
    • L. Zhou, Z. Zuo, and M.S. Chow Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use Journal of Clinical Pharmacology 45 2005 1345 1359 (Pubitemid 41643896)
    • (2005) Journal of Clinical Pharmacology , vol.45 , Issue.12 , pp. 1345-1359
    • Zhou, L.1    Zuo, Z.2    Chow, M.S.S.3
  • 59
    • 33845762340 scopus 로고    scopus 로고
    • Multi-target therapeutics: when the whole is greater than the sum of the parts
    • DOI 10.1016/j.drudis.2006.11.008, PII S1359644606004697
    • G.R. Zimmermann, J. Lehar, and C.T. Keith Multi-target therapeutics: when the whole is greater than the sum of the parts Drug Discovery Today 12 2007 34 42 (Pubitemid 46014485)
    • (2007) Drug Discovery Today , vol.12 , Issue.1-2 , pp. 34-42
    • Zimmermann, G.R.1    Lehar, J.2    Keith, C.T.3


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