The role of mitochondria-mediated intrinsic death pathway in gingerdione derivative I6-induced neuronal apoptosis

Food and Chemical Toxicology

Volumn 50, Issue 3-4, 2012, Pages 1073-1081

  Lin, Chia Ho ^a   Chen, Po See ^b   Kuo, Sheng Chu ^c   Huang, Li Jiau ^c   Gean, Po Wu ^b   Chiu, Ted H ^a  

^a TZU CHI UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Antioxidant; Apoptosis; Gingerdione; Poly(ADP ribose)polymerase; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CASPASE 3; CASPASE 9; CYTOCHROME C; CYTOTOXIC AGENT; I6; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN MITOCHONDRION; CELL DENSITY; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL TARGETING SIGNAL; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; TOXICITY TESTING;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CASPASE 3; CELLS, CULTURED; ENZYME ACTIVATION; FRONTAL LOBE; GUAIACOL; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA; NEURONS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84862795399     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.11.053     Document Type: Article

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