Anti-inflammatory effects of methoxyphenolic compounds on human airway cells

Journal of Inflammation

Volumn 9, Issue , 2012, Pages

  Houser, Kenneth R ^a   Johnson, David K ^b   Ishmael, Faoud T ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Airway; Cytokines; Epithelium; Inflammation; Methoxyphenols; Post transcriptional regulation

Indexed keywords

2 METHOXYHYDROQUINONE; 4 AMINO 2 METHOXYPHENOL; 4 FLUORO 2 METHOXYPHENOL; 4 HYDROXY 3 METHOXYBENZONITRILE; ANTIINFLAMMATORY AGENT; APOCYNIN; CREOSOL; CXCL1 CHEMOKINE; DIAPOCYNIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GUAIACOL; HUR PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; REACTIVE OXYGEN METABOLITE; RESVERATROL; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; EPITHELIUM CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEIN RNA BINDING; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE ANALYSIS; RESPIRATORY EPITHELIUM; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

EID: 84862794090     PISSN: None     EISSN: 14769255     Source Type: Journal    
DOI: 10.1186/1476-9255-9-6     Document Type: Article

References (34)

1. Epithelium: at the interface of innate and adaptive immune responses. Schleimer RP, Kato A, Kern R, Kuperman D, Avila PC, J Allergy Clin Immunol 2007 120 1279 1284 10.1016/j.jaci.2007.08.046 17949801 (Pubitemid 350216601)
2. Innate and acquired immunity and epithelial cell function in chronic rhinosinusitis. Schleimer RP, Lane AP, Kim J, Clin Allergy Immunol 2007 20 51 78 17534045
3. Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators. Martin LD, Rochelle LG, Fischer BM, Krunkosky TM, Adler KB, Eur Respir J 1997 10 2139 2146 10.1183/09031936.97.10092139 9311517 (Pubitemid 27406456)
4. Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: requirement of Ras/mitogen-activated protein kinases in the activation of NF-kappaB by oxidants. Janssen-Heininger YM, Macara I, Mossman BT, Am J Respir Cell Mol Biol 1999 20 942 952 10226064 (Pubitemid 129540852)
5. Tumor necrosis factor-alpha increases airway smooth muscle oxidants production through a NADPH oxidase-like system to enhance myosin light chain phosphorylation and contractility. Thabut G, El-Benna J, Samb A, Corda S, Megret J, Leseche G, Vicaut E, Aubier M, Boczkowski J, J Biol Chem 2002 277 22814 22821 10.1074/jbc.M200315200 11940577 (Pubitemid 34967262)
6. Transcriptional and post-transcriptional control of gene expression in inflammation. Kracht M, Saklatvala J, Cytokine 2002 20 91 106 10.1006/cyto.2002.0895 12453467 (Pubitemid 35370689)
7. Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium. Fan J, Ishmael FT, Fang X, Myers A, Cheadle C, Huang SK, Atasoy U, Gorospe M, Stellato C, J Immunol 2011 186 2482 2494 10.4049/jimmunol.0903634 21220697
8. Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Johnson DK, Schillinger KJ, Kwait DM, Hughes CV, McNamara EJ, Ishmael F, O'Donnell RW, Chang MM, Hogg MG, Dordick JS, et al. Endothelium 2002 9 191 203 10.1080/10623320213638 12380644 (Pubitemid 35021589)
9. Apocynin: molecular aptitudes. Stefanska J, Pawliczak R, Mediators Inflamm 2008 2008 106507 19096513
10. The oxidation of apocynin catalyzed by myeloperoxidase: proposal for NADPH oxidase inhibition. Ximenes VF, Kanegae MP, Rissato SR, Galhiane MS, Arch Biochem Biophys 2007 457 134 141 10.1016/j.abb.2006.11.010 17166480 (Pubitemid 46048700)
11. Apocynin, NADPH oxidase, and vascular cells: a complex matter. Touyz RM, Hypertension 2008 51 172 174 10.1161/HYPERTENSIONAHA.107.103200 18086948 (Pubitemid 351159922)
12. Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions. Vilcek J, Lee TH, J Biol Chem 1991 266 7313 7316 1850405 (Pubitemid 21906368)
13. Dose formulation and analysis of diapocynin. Luchtefeld R, Luo R, Stine K, Alt ML, Chernovitz PA, Smith RE, J Agric Food Chem 2008 56 301 306 10.1021/jf072792n 18092754 (Pubitemid 351212548)
14. Synthesis of diapocynin. Dasari MS, Richards KM, Alt ML, Crawford CFP, Schleiden A, Ingram J, Hamiclou AAA, Williams A, Chernovitz PA, Luo RS, et al. J Chem Educ 2008 85 411 412 10.1021/ed085p411
15. Real time quantitative PCR. Heid CA, Stevens J, Livak KJ, Williams PM, Genome Res 1996 6 986 994 10.1101/gr.6.10.986 8908518 (Pubitemid 26388091)
16. Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR. Atasoy U, Curry SL, Lopez-de-Silanes I, Shyu AB, Casolaro V, Gorospe M, Stellato C, J Immunol 2003 171 4369 4378 14530362 (Pubitemid 37238715)
17. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M, J Immunol 1983 130 1910 1917 6833755 (Pubitemid 13091657)
18. Role of the RNA-binding protein tristetraprolin in glucocorticoid- mediated gene regulation. Ishmael FT, Fang X, Galdiero MR, Atasoy U, Rigby WF, Gorospe M, Cheadle C, Stellato C, J Immunol 2008 180 8342 8353 18523301
19. Mediators of chronic obstructive pulmonary disease. Barnes PJ, Pharmacol Rev 2004 56 515 548 10.1124/pr.56.4.2 15602009 (Pubitemid 39658462)
20. Post-transcriptional control of cytokine production. Anderson P, Nat Immunol 2008 9 353 359 10.1038/ni1584 18349815 (Pubitemid 351405104)
21. Anti-inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation. Kim SY, Moon KA, Jo HY, Jeong S, Seon SH, Jung E, Cho YS, Chun E, Lee KY, Immunol Cell Biol 2011
22. Effects of methoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neutrophils. Van den Worm E, Beukelman CJ, Van den Berg AJ, Kroes BH, Labadie RP, Van Dijk H, Eur J Pharmacol 2001 433 225 230 10.1016/S0014-2999(01)01516-3 11755156 (Pubitemid 34045183)
23. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Ghosh S, May MJ, Kopp EB, Annu Rev Immunol 1998 16 225 260 10.1146/annurev.immunol.16.1.225 9597130 (Pubitemid 28183365)
24. Signal transduction through NF-kappa B. May MJ, Ghosh S, Immunol Today 1998 19 80 88 10.1016/S0167-5699(97)01197-3 9509763 (Pubitemid 28097654)
25. Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice. Muijsers RB, van Ark I, Folkerts G, Koster AS, van Oosterhout AJ, Postma DS, Nijkamp FP, Br J Pharmacol 2001 134 434 440 10.1038/sj.bjp. 0704235 11564663 (Pubitemid 32989142)
26. The many roles of chemokines and chemokine receptors in inflammation. Charo IF, Ransohoff RM, N Engl J Med 2006 354 610 621 10.1056/NEJMra052723 16467548 (Pubitemid 43209108)
27. Monocyte chemoattractant protein-1 (MCP-1): an overview. Deshmane SL, Kremlev S, Amini S, Sawaya BE, J Interferon Cytokine Res 2009 29 313 326 10.1089/jir.2008.0027 19441883
28. Apocynin decreases hydrogen peroxide and nitrate concentrations in exhaled breath in healthy subjects. Stefanska J, Sokolowska M, Sarniak A, Wlodarczyk A, Doniec Z, Nowak D, Pawliczak R, Pulm Pharmacol Ther 2010 23 48 54 10.1016/j.pupt.2009.09.003 19786113
29. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Donnelly LE, Newton R, Kennedy GE, Fenwick PS, Leung RH, Ito K, Russell RE, Barnes PJ, Am J Physiol Lung Cell Mol Physiol 2004 287 774 783 10.1152/ajplung.00110.2004 15180920 (Pubitemid 39249390)
30. Diapocynin versus apocynin as pretranscriptional inhibitors of NADPH oxidase and cytokine production by peripheral blood mononuclear cells. Kanegae MP, Condino-Neto A, Pedroza LA, de Almeida AC, Rehder J, da Fonseca LM, Ximenes VF, Biochem Biophys Res Commun 2010 393 551 554 10.1016/j.bbrc.2010.02.073 20171179
31. Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells. Vejrazka M, Micek R, Stipek S, Biochim Biophys Acta 2005 1722 143 147 10.1016/j.bbagen.2004.12.008 15716123 (Pubitemid 40299004)
32. NF-kappaB activation by reactive oxygen species: fifteen years later. Gloire G, Legrand-Poels S, Piette J, Biochem Pharmacol 2006 72 1493 1505 10.1016/j.bcp.2006.04.011 16723122 (Pubitemid 44666727)
33. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. Peng SS, Chen CY, Xu N, Shyu AB, EMBO J 1998 17 3461 3470 10.1093/emboj/17.12.3461 9628881 (Pubitemid 28279518)
34. Regulation of HuR by DNA Damage Response Kinases. Kim HH, Abdelmohsen K, Gorospe M, J Nucleic Acids 2010 2010 1 8