Effects of methoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neutrophils

European Journal of Pharmacology

Volumn 433, Issue 2-3, 2001, Pages 225-230

  Van den Worm, Edwin ^a   Beukelman, Cees J ^a   Van den Berg, Albert J J ^a   Kroes, Burt H ^a   Labadie, Rudi P ^a   Van Dijk, Hans ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Apocynin; NADPH oxidase; Neutrophil; Reactive oxygen species; Respiratory burst

Indexed keywords

ACETOPHENONE DERIVATIVE; ACETOSYRINGONE; ALDEHYDE DERIVATIVE; APOCYNIN; NONSTEROID ANTIINFLAMMATORY AGENT; PICRORHIZA KURROA EXTRACT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STEROID; SYRINGALDEHYDE; SYRINGIC ACID; UNCLASSIFIED DRUG; VANILLIC ACID; VANILLIN;

ARTHRITIS; ARTICLE; ATHEROSCLEROSIS; CELL FUNCTION; CHEMICAL MODIFICATION; COLITIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG ISOLATION; DRUG SAFETY; DRUG STRUCTURE; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ACTIVATION; MEDICINAL PLANT; NEUTROPHIL; NORMAL HUMAN; PHAGOCYTE; PLANT; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ACETOPHENONES; ACRIDINES; ANTI-INFLAMMATORY AGENTS; CHEMILUMINESCENT MEASUREMENTS; HUMANS; LUMINOL; NEUTROPHILS; PEROXIDASE; REACTIVE OXYGEN SPECIES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE;

EID: 0035930856     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01516-3     Document Type: Article

References (32)

1. Comparison between luminol- and lucigenin-dependent chemiluminescence of polymorphnuclear leukocytes
2. Oxygen-dependent microbial killing by phagocytes
3. The respiratory burst oxidase
4. Diacylglycerol generation and phosphoinositide turnover in human neutrophils: Effects of particulate versus soluble stimuli
5. Role of myeloperoxidase in luminol-dependent chemiluminescence of polymorphonuclear leukocytes
6. Pattern of formylmethionyl-leucyl-phenylalanine-induced luminol- and lucigenin-dependent chemiluminescence in human neutrophils
7. Localization of the luminol-dependent chemiluminescence reaction in human granulocytes
8. Antiasthmatic acetophenones - An in vivo study on structure activity relationship
9. Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism
10. Analysis of an industrial smoke preparation part VI; acute toxicity, bactericidal, and antioxidative activities of some phenolic fraction components of industrial smoke preparation
11. Intracellular control of human neutrophil secretion
12. Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells
13. Current concepts: Immunology. Neutrophils in human disease
14. Activation of the respiratory burst enzyme in human polymorphnuclear leukocytes by chemoattractants and other soluble stimuli: Evidence that the same oxidase is activated by different transductional mechanisms
15. Role of the phagocyte in host-parasite interactions: XII. Hydrogen peroxide-myeloperoxidase bactericidal system in the phagocyte
16. 2+
17. Role of superoxide anions in airway hyperresponsiveness induced by cigarette smoke in conscious guinea pigs
18. Interaction between human neutrophils and zymosan particles: The role of opsonins and divalent cations
19. Prolifaration of airway epithelium after ozone exposure: Effect of apocynin and dexamethasone
20. Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils
21. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol
22. Apocynin improves the efficacy of secretory leukocyte protease inhibitor in experimental emphysema
23. Acetophenones - Compounds from plant origin with inhibitory effects on neutrophil in vitro respiration burst activity
24. Effect of NADPH-oxidase inhibition on endothelial cell ELAM-1 mRNA expression
25. Antiarthritic activity of the newly developed neutrophil oxidative burst antagonist apocynin
26. Effects of apocynin on the induction of ulcerative lesions in rat skin injected with tubercle bacteria
27. Reactive oxygen species are required for the phagocytosis of myelin by macrophages
28. Phagocytosis and killing of staphylococci by human polymorphonuclear and mononuclear leukocytes
29. Tissue destruction by neutrophils
30. Oxygen radicals in exsanguination-induced bronchoconstriction of guinea pigs