Splenocyte apoptosis and autophagy is mediated by interferon regulatory factor 1 during murine endotoxemia

Shock

Volumn 37, Issue 5, 2012, Pages 511-517

  Zhang, Lemeng ^a,b   Cardinal, Jon S ^a   Pan, Pinhua ^a,b   Rosborough, Brian R ^a   Chang, Ying ^a   Yan, Wei ^a   Huang, Hai ^a   Billiar, Timothy R ^a   Rosengart, Matthew R ^a   Tsung, Allan ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Endotoxemia; IRF 1; Splenocyte

Indexed keywords

CASPASE 8; CASPASE 9; INTERFERON REGULATORY FACTOR 1; MAMMALIAN TARGET OF RAPAMYCIN; MYELOID DIFFERENTIATION FACTOR 88; S6 KINASE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; ENDOTOXEMIA; IN VIVO STUDY; KNOCKOUT MOUSE; MACROPHAGE; MALE; MITOCHONDRION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPLEEN CELL;

ANIMALS; APOPTOSIS; AUTOPHAGY; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; INTERFERON REGULATORY FACTOR-1; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SPLEEN; TOLL-LIKE RECEPTOR 4; TOR SERINE-THREONINE KINASES;

EID: 84862790713     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e318249cfa2     Document Type: Article

References (40)

1. Aneja R, Fink MP: Promising therapeutic agents for sepsis. Trends Microbiol 15(1):31-37, 2007. (Pubitemid 46038730)
2. Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO: The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458(7242): 1191-1195, 2009.
3. Chopra M, Sharma AC: Distinct cardiodynamic and molecular characteristics during early and late stages of sepsis-induced myocardial dysfunction. Life Sci 81(4):306-316, 2007. (Pubitemid 47030576)
4. Xiao H, Siddiqui J, Remick DG: Mechanisms of mortality in early and late sepsis. Infect Immun 74(9):5227-5235, 2006. (Pubitemid 44300441)
5. Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, Buchman TG, Karl IE: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27(7):1230-1251, 1999. (Pubitemid 29379358)
6. Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A: Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol 78(2):325-337, 2005. (Pubitemid 41061305)
7. Wesche-Soldato DE, Swan RZ, Chung CS, Ayala A: The apoptotic pathway as a therapeutic target in sepsis. Curr Drug Targets 8(4):493-500, 2007. (Pubitemid 46672616)
8. Chung CS, Song GY, Lomas J, Simms HH, Chaudry IH, Ayala A: Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity. J Leukoc Biol 74(3):344-351, 2003. (Pubitemid 38040394)
9. Hotchkiss RS, Nicholson DW: Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 6(11):813-822, 2006. (Pubitemid 44631650)
10. Schwulst SJ, Muenzer JT, Peck-Palmer OM, Chang KC, Davis CG, McDonough JS, Osborne DF, Walton AH, Unsinger J, McDunn JE, et al.: Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis. Shock 30(2):127-134, 2008.
11. Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, et al.: Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 12(3):222-230, 2011.
12. Levine B, Yuan J: Autophagy in cell death: an innocent convict? J Clin Invest 115(10):2679-2688, 2005. (Pubitemid 41434392)
13. Carchman EH, Rao J, Loughran PA, Rosengart MR, Zuckerbraun BS: Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice. Hepatology 53(6):2053-2062, 2011.
14. Hsiao HW, Tsai KL, Wang LF, Chen YH, Chiang PC, Chuang SM, Hsu C: The decline of autophagy contributes to proximal tubular dysfunction during sepsis. Shock 37(3):289-296, 2011.
15. Hamacher-Brady A, Brady NR, Gottlieb RA: Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem 281(40):29776-29787, 2006. (Pubitemid 44536987)
16. Xu Y, Jagannath C, Liu XD, Sharafkhaneh A, Kolodziejska KE, Eissa NT: Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27(1):135-144, 2007. (Pubitemid 47089027)
17. Deretic V: Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunol Rev 240(1):92-104, 2011.
18. Schmid D, Munz C: Innate and adaptive immunity through autophagy. Immunity 27(1):11-21, 2007. (Pubitemid 47089030)
19. Xu Y, Liu XD, Gong X, Eissa NT: Signaling pathway of autophagy associated with innate immunity. Autophagy 4(1):110-112, 2008.
20. Mizushima N, Levine B, Cuervo AM, Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature 451(7182):1069-1075, 2008. (Pubitemid 351317450)
21. Levine B, Deretic V: Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol 7(10):767-777, 2007. (Pubitemid 47480305)
22. Levine B: Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell 120(2):159-162, 2005. (Pubitemid 40174758)
23. Kroger A, Koster M, Schroeder K, Hauser H, Mueller PP: Activities of IRF-1. J Interferon Cytokine Res 22(1):5-14, 2002. (Pubitemid 34161278)
24. Dhupar R, Klune JR, Evankovich J, Cardinal J, Zhang M, Ross M, Murase N, Geller DA, Billiar TR, Tsung A: Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury. Shock 35(3):293-301, 2010.
25. Senaldi G, Shaklee CL, Guo J, Martin L, Boone T, Mak TW, Ulich TR: Protection against the mortality associated with disease models mediated by TNF and IFN-gamma in mice lacking IFN regulatory factor-1. J Immunol 163(12): 6820-6826, 1999.
26. Stang MT, Armstrong MJ, Watson GA, Sung KY, Liu Y, Ren B, Yim JH: Interferon regulatory factor-1-induced apoptosis mediated by a ligandindependent Fas-associated death domain pathway in breast cancer cells. Oncogene 26(44):6420-6430, 2007. (Pubitemid 47494223)
27. Papageorgiou A, Dinney CP, McConkey DJ: Interferon-alpha induces TRAIL expression and cell death via an IRF-1-dependent mechanism in human bladder cancer cells. Cancer Biol Ther 6(6):872-879, 2007. (Pubitemid 351574976)
28. Kano A, Haruyama T, Akaike T, Watanabe Y: IRF-1 is an essential mediator in IFN-gammaYinduced cell cycle arrest and apoptosis of primary cultured hepatocytes. Biochem Biophys Res Commun 257(3):672-677, 1999. (Pubitemid 29301501)
29. Tamura T, Ishihara M, Lamphier MS, Tanaka N, Oishi I, Aizawa S, Matsuyama T, Mak TW, Taki S, Taniguchi T: An IRF-1-dependent pathway of DNA damageYinduced apoptosis in mitogen-activated T lymphocytes. Nature 376(6541):596-599, 1995.
30. Chung CS, Venet F, Chen Y, Jones LN, Wilson DC, Ayala CA, Ayala A: Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival. Shock 34(2):150-161, 2010.
31. Watanabe E, Muenzer JT, Hawkins WG, Davis CG, Dixon DJ, McDunn JE, Brackett DJ, Lerner MR, Swanson PE, Hotchkiss RS: Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest 89(5):549-561, 2009.
32. Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE: Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol 174(8):5110-5118, 2005.
33. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 348(2):138-150, 2003. (Pubitemid 36056721)
34. Hotchkiss RS, Tinsley KW, Swanson PE, Schmieg RE Jr, Hui JJ, Chang KC, Osborne DF, Freeman BD, Cobb JP, Buchman TG, et al.: Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol 166(11):6952-6963, 2001. (Pubitemid 32467243)
35. Hotchkiss RS, Tinsley KW, Swanson PE, Grayson MH, Osborne DF, Wagner TH, Cobb JP, Coopersmith C, Karl IE: Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol 168(5):2493-2500, 2002. (Pubitemid 34171855)
36. Peck-Palmer OM, Unsinger J, Chang KC, McDonough JS, Perlman H, McDunn JE, Hotchkiss RS: Modulation of the Bcl-2 family blocks sepsisinduced depletion of dendritic cells and macrophages. Shock 31(4):359-366, 2009.
37. Hotchkiss RS, Chang KC, Swanson PE, Tinsley KW, Hui JJ, Klender P, Xanthoudakis S, Roy S, Black C, Grimm E, et al.: Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol 1(6):496-501, 2000.
38. Hotchkiss RS, Tinsley KW, Swanson PE, Chang KC, Cobb JP, Buchman TG, Korsmeyer SJ, Karl IE: Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci USA 96(25):14541-14546, 1999. (Pubitemid 30000686)
39. Barkhausen T, Frerker C, Putz C, Pape HC, Krettek C, van Griensven M: Depletion of NK cells in a murine polytrauma model is associated with improved outcome and a modulation of the inflammatory response. Shock 30(4): 401-410, 2008.
40. Pua HH, Dzhagalov I, Chuck M, Mizushima N, He YW: A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 204(1): 25-31, 2007. (Pubitemid 46148752)