Capture of the volatile carbonyl metabolite of flecainide on 2,4-dinitrophenylhydrazine cartridge for quantitation by stable-isotope dilution mass spectrometry coupled with chromatography

Journal of Chromatography A

Volumn 1232, Issue , 2012, Pages 281-287

  Prokai, Laszlo ^a   Szarka, Szabolcs ^a   Wang, Xiaoli ^a,b   Prokai Tatrai, Katalin ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

2,4 Dinitrophenylhydrazine (DNPH) cartridge; 15N labeled internal standard; GC MS; LC MS; Volatile carbonyl metabolite

Indexed keywords

2 ,4-DINITROPHENYLHYDRAZINE; CYTOCHROME P450; DEALKYLATION; DERIVATIZATIONS; GASEOUS SAMPLES; GC-MS; HUMAN LIVER MICROSOMES; HYDRAZONES; IN-VITRO; INTERNAL STANDARDS; ISOTOPE EFFECT; LC-ESI-MS; LC-MS; LIMITS OF DETECTION; MASS SPECTROMETRIC ANALYSIS; METABOLIC PROCESS; NEGATIVE CHEMICAL IONIZATION; SELECTED-ION MONITORING; SOLVENT FREE; TRIFLUOROACETALDEHYDE; VOLATILE CHEMICALS;

ALDEHYDES; BYPRODUCTS; CHEMICAL DETECTION; CHROMATOGRAPHY; DEUTERIUM; ELECTROSPRAY IONIZATION; KETONES; MASS SPECTROMETRY; METABOLISM; METABOLITES; ORGANIC COMPOUNDS;

PROJECTILES;

2,4 DINITROPHENYLHYDRAZINE; ALDEHYDE; CYTOCHROME P450; FLECAINIDE; KETONE;

ACCURACY; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DEALKYLATION; DERIVATIZATION; ELECTROSPRAY; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; IONIZATION; LIMIT OF DETECTION; MICROSOME; PRIORITY JOURNAL; SYNTHESIS; VALIDITY;

ACETALDEHYDE; CHROMATOGRAPHY, LIQUID; FLECAINIDE; HUMANS; MASS SPECTROMETRY; MICROSOMES, LIVER; NITROGEN ISOTOPES; PHENYLHYDRAZINES;

EID: 84862782024     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.01.067     Document Type: Article

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