Design and Synthesis of N-Substituted Indazole-3-Carboxamides as Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors

Chemical Biology and Drug Design

Volumn 79, Issue 4, 2012, Pages 488-496

  Patel, Maulik R ^a   Pandya, Kashyap G ^a   Lau Cam, Cesar A ^a   Singh, Satyakam ^a   Pino, Maria A ^a   Billack, Blase ^a   Degenhardt, Kurt ^a   Talele, Tanaji T ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

2,3 dioxoindoline; Diabetes; Docking; Indazole 3 carboxamide; PARP 1

Indexed keywords

1 [3 (2,3 DIOXOINDOLIN 1 YL)PROPYL] 1H INDAZOLE 3 CARBOXAMIDE; 1 [3 (5 BROMO 2,3 DIOXOINDOLIN 1 YL)PROPYL] 1H INDAZOLE 3 CARBOXAMIDE; 1 [3 (5 CHLORO 2,3 DIOXOINDOLIN 1 YL)PROPYL] 1H INDAZOLE 3 CARBOXAMIDE; 1 [3 (5 FLUORO 2,3 DIOXOINDOLIN 1 YL)PROPYL] 1H INDAZOLE 3 CARBOXAMIDE; 1 [3 (5 IODO 2,3 DIOXOINDOLIN 1 YL)PROPYL] INDAZOLE 3 CARBOXAMIDE; 1 [3 (5 METHOXY 2,3 DIOXOINDOLIN 1 YL)PROPYL] 1H INDAZOLE 3 CARBOXAMIDE; 1 [3 (PIPERIDIN 1 YL)PROPYL] 1H INDAZOLE 3 CARBOXAMIDE; 1H INDAZOLE 3 CARBOXAMIDE; 5 [1 [3 (2,3 DIOXOINDOLIN 1 YL)PROPYL] 1H INDAZOLE 3 CARBOXAMIDE; [1 [3 (PIPERIDINE 1 YL)PROPYL] 1H INDAZOLE 3 CARBOXAMIDE; AMIDE; ANTIDIABETIC AGENT; GLUCOSE; INDAZOLE DERIVATIVE; INSULIN; N (3 CHLOROPROPYL) 1H INDAZOLE 3 CARBOXAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CATALYSIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIABETES MELLITUS; DRUG DESIGN; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; HYDROGEN BOND; HYPERGLYCEMIA; IC 50; IN VITRO STUDY; INSULIN RELEASE; MALE; MOLECULAR DOCKING; NONHUMAN; PANCREAS SECRETION; PHARMACOPHORE; PRIORITY JOURNAL; PROTECTION; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TREATMENT RESPONSE;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DRUG DESIGN; HYPOGLYCEMIC AGENTS; INDAZOLES; INSULIN; MALE; MODELS, MOLECULAR; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84862781371     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2011.01302.x     Document Type: Article

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