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1
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70350699283
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A SciFinder search of the indazole core structure returned 57,227 individual hits. A text search of indazole returned 4,364 references
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A SciFinder search of the indazole core structure returned 57,227 individual hits. A text search of indazole returned 4,364 references.
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2
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0037612561
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Cheung, M.; Boloor, A.; Stafford, J. A. J. Org. Chem. 2003, 68, 4093.
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(2003)
J. Org. Chem.
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, pp. 4093
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Cheung, M.1
Boloor, A.2
Stafford, J.A.3
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5
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0029984031
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(c) Morel, S.; Boyer, G.; Coullet, F.; Galy, J.-P. Synth. Commun. 1996, 26, 2443.
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(1996)
Synth. Commun.
, vol.26
, pp. 2443
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Morel, S.1
Boyer, G.2
Coullet, F.3
Galy, J.-P.4
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6
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0000245224
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(d) Boyer, G.; Galy, J.-P.; Barbe, J. Heterocycles 1995, 41, 487.
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(1995)
Heterocycles
, vol.41
, pp. 487
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Boyer, G.1
Galy, J.-P.2
Barbe, J.3
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7
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33847723490
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For a selective N1 substitution via a reversible 1,4 addition, see: Saenz, J.; Mitchell, M.; Bahmanyar, S.; Stankovic, N.; Perry, M.; CraigWoods, B.; Kline, B.; Yu, S.; Albizati, K. Org. Process Res. Dev. 2007, 11, 30-38.
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(2007)
Org. Process Res. Dev.
, vol.11
, pp. 30-38
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Saenz, J.1
Mitchell, M.2
Bahmanyar, S.3
Stankovic, N.4
Perry, M.5
Craigwoods, B.6
Kline, B.7
Yu, S.8
Albizati, K.9
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8
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70350690404
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For brevity, we refer to the "1-alkyl-1H" and "2-alkyl-2H" products as the "N1" and "N2" products, respectively
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For brevity, we refer to the "1-alkyl-1H" and "2-alkyl-2H" products as the "N1" and "N2" products, respectively.
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9
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0038053032
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The high yield of the isolated product implies good selectivity
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(a) The high yield of the isolated product implies good selectivity: Muri, E. M. F.; Mishra, H.; Avery, M. A.; Williamson, J. S. Synth. Commun. 2003, 33, 1977.
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(2003)
Synth. Commun.
, vol.33
, pp. 1977
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Muri, E.M.F.1
Mishra, H.2
Avery, M.A.3
Williamson, J.S.4
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10
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0034676315
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(b) The reaction of methyl bromoacetate with 6-nitroindazole was reported in 34% yield: Han, Q.; Dominguez, C.; Stouten, P. F. W.; Park, J. M.; Duffy, D. E.; Galemmo, R. A., Jr.; Rossi, K. A.; Alexander, R. S.; Smallwood, A. M.; Wong, P. C.; Wright, M. M.; Leuttgen, J. M.; Knabb, R. M.; Wexler, R. R. J. Med. Chem. 2000, 43, 4398.
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(2000)
J. Med. Chem.
, vol.43
, pp. 4398
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Han, Q.1
Dominguez, C.2
Stouten, P.F.W.3
Park, J.M.4
Duffy, D.E.5
Galemmo Jr., R.A.6
Rossi, K.A.7
Alexander, R.S.8
Smallwood, A.M.9
Wong, P.C.10
Wright, M.M.11
Leuttgen, J.M.12
Knabb, R.M.13
Wexler, R.R.14
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11
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70350694121
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The poor selectivity with dioxane (∼1:1) allowed for isolation of the pure N2 product for mechanistic studies
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The poor selectivity with dioxane (∼1:1) allowed for isolation of the pure N2 product for mechanistic studies.
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12
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70350651899
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Proton sponge: l,8-bis(dimethylamino)naphthalene
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Proton sponge: l,8-bis(dimethylamino)naphthalene.
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13
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2742558734
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Under solvent-tree conditions, microwave radiation cleanly provides the N1 product of indazole and 2-bromo-l-(4-bromophenyl)ethanone: Pérez, E.; Sotelo, E.; Loupy, A.; Mocelo, R.; Suarez, M.; Pérez, R.; Autié, M. Heterocycles 1996, 43, 539.
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(1996)
Heterocycles
, vol.43
, pp. 539
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Pérez, E.1
Sotelo, E.2
Loupy, A.3
Mocelo, R.4
Suarez, M.5
Pérez, R.6
Autié, M.7
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14
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0028292905
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Atwell, G. J.; Sykes, B. M.; O'Conner, C. J.; Denny, W. A. J. Med. Chem. 1994, 37, 371.
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(1994)
J. Med. Chem.
, vol.37
, pp. 371
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Atwell, G.J.1
Sykes, B.M.2
O'Conner, C.J.3
Denny, W.A.4
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15
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34548293743
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(a) Von Auwers, K.; Ernecke, A.; Wolter, E. Ann. 1930, 478, 154.
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(1930)
Ann.
, vol.478
, pp. 154
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Von Auwers, K.1
Ernecke, A.2
Wolter, E.3
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16
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33845461050
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(b) Yamazaki, T.; Baum, G.; Shechter, H. Tetrahedron Lett. 1974,15,4421.
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(1974)
Tetrahedron Lett.
, vol.15
, pp. 4421
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Yamazaki, T.1
Baum, G.2
Shechter, H.3
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18
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0035874731
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Isin, E. M.; de Jonge, M.; Castagnoli, N., Jr. J. Org. Chem. 2001, 66, 4220.
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(2001)
J. Org. Chem.
, vol.66
, pp. 4220
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Isin, E.M.1
De Jonge, M.2
Castagnoli Jr., N.3
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21
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70350641758
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See Supporting Information.
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See Supporting Information.
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