Crystal structure of type I ryanodine receptor amino-terminal β-trefoil domain reveals a disease-associated mutation "hot spot" loop

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 27, 2009, Pages 11040-11044

  Amador, Fernando J ^a   Liu, Shuang ^a   Ishiyama, Noboru ^a   Plevin, Michael J ^a,c   Wilson, Aaron ^b   MacLennan, David H ^b   Ikura, Mitsuhiko ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Central core disease; Malignant hyperthermia; Nuclear magnetic resonance; X ray crystal structure

Indexed keywords

HELIX LOOP HELIX PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; RYANODINE RECEPTOR 1; TREFOIL PEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CRYSTAL STRUCTURE; GENE MUTATION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ANIMALS; ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA; CRYSTALLOGRAPHY, X-RAY; DISEASE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MALIGNANT HYPERTHERMIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; MYOPATHY, CENTRAL CORE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RABBITS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SOLUTIONS;

LOTUS;

EID: 67650469595     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905186106     Document Type: Article

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