Neurocognitive and clinical dysfunction in adult Chinese, nonpsychotic relatives of patients with schizophrenia: Findings from the Changsha study and evidence for schizotaxia

Asian Journal of Psychiatry

Volumn 5, Issue 1, 2012, Pages 83-92

  Stone, William S ^a   Hsi, Xiaolu ^a,d   Tan, Liwen ^b   Zhu, Shaochun ^a   Li, Lingjiang ^b   Giuliano, Anthony J ^a   Seidman, Larry J ^a   Tsuang, Ming T ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Negative symptoms; Neurocognitive function; Scale; Schizophrenia; Schizotaxia; Social adjustment

Indexed keywords

ADULT; ARTICLE; CHINESE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; PRIORITY JOURNAL; RELATIVE; SCHIZOPHRENIA; SCHIZOTAXIA; SOCIAL INTERACTION; SOCIAL STATUS; SYMPTOM; CASE CONTROL STUDY; CHINA; CLUSTER ANALYSIS; COGNITIVE DYSFUNCTION; FAMILY; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER; SOCIAL ADAPTATION; YOUNG ADULT;

ADULT; CASE-CONTROL STUDIES; CHINA; CLUSTER ANALYSIS; COGNITIVE DYSFUNCTION; FAMILY; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER; SOCIAL ADJUSTMENT; YOUNG ADULT;

EID: 84862776907     PISSN: 18762018     EISSN: 18762026     Source Type: Journal    
DOI: 10.1016/j.ajp.2011.11.007     Document Type: Article

References (46)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) 1994, American Psychiatric Association, Washington, DC.
2. Andreasen N.C. The Scale for the Assessment of Negative Symptoms (SANS) 1983, The University of Iowa, Iowa City, Iowa.
3. Braff D.L., Freedman R., et al. Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophrenia Bulletin 2007, 33:21-32.
4. Brewer W.J, Wood S.J., et al. Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis. Schizophrenia Bulletin 2006, 32:538-555.
5. Cohen J. Statistical Power Analysis for the Behavioral Sciences 1988, Lawrence Earlbaum, Hillsdale, N.J.
6. Eack S.M., Greenwald D.P., et al. Cognitive enhancement therapy for early-course schizophrenia: effects of a two-year randomized controlled trial. Psychiatric Services 2009, 60:1468-1476.
7. Erlenmeyer-Kimling L., Rock D., et al. Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: the New York High-Risk Project. American Journal of Psychiatry 2000, 157(9):1416-1422.
8. Faraone S.V., Green A.I., et al. " Schizotaxia" : clinical implications and new directions for research. Schizophrenia Bulletin 2001, 27:1-18.
9. Faraone S.V, Kremen W.S., et al. Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes?. American Journal of Psychiatry 1995, 152:1286-1290.
10. Faraone S.V., Seidman L.J., et al. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. Journal of Abnormal Psychology 1995, 104:286-304.
11. Goto N., Yohimura R., et al. Associations between plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and negative symptoms or cognitive impairments in early-stage schizophrenia. Human Psychopharmacology 2009, 24:639-645.
12. Gottesman I.I, McGuffin P., et al. Clinical genetics as clues to the " real" genetics of schizophrenia (a decade of modest gains while playing for time). Schizophrenia Bulletin 1987, 13(1):23-47.
13. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry 2003, 160:636-645.
14. Gottesman I.I, Shields J. Schizophrenia: The Epigenetic Puzzle 1982, Cambridge University Press, Cambridge.
15. Gur R.E., Calkins M.E., et al. The consortium on the genetics of schizophrenia (COGS): neurocognitive endophenotypes. Schizophrenia Bulletin 2007, 33:49-68.
16. Hair J.F., Black W.C. Cluster analysis. Reading and Understanding More Multivariate Statistics 2000, 147-205. American Psychological Association, Washington, D.C. L.G. Grimm, P.R. Yarnold, L.G. Grimm, P.R. Yarnold (Eds.).
17. Hays W.L. Statistics 1994, Harcourt Brace, Fort Worth, Texas.
18. Kaufman L., Rousseau P. Finding Groups in Data 1990, Wiley, New York.
19. Keefe R.S.E., Perkins D.O., et al. A longitudinal study of neurocognitive function in individuals at-risk for psychosis. Schizophrenia Research 2006, 88:26-35.
20. Kendler K.S, Lieberman J.A., et al. The structured interview for schizotypy (SIS): a preliminary report. Schizophrenia Bulletin 1989, 15(4):559-571.
21. Keshavan M.S., Montrose D.M., et al. Psychopathology among offspring of parents with schizophrenia: relationship to premorbid impairments. Schizophrenia Research 2008, 103:114-120.
22. Kleinbaum D.G, Kupper L.L., et al. Applied Regression and Other Multivariate Methods 1988, PWS-Kent Publishing, Boston.
23. Kremen W.S., Hoff A.L. Neurocognitive deficits in the biological relatives of individuals with schizophrenia. Early Clinical Intervention and Prevention with Schizophrenia 2004, 133-158. Totowa, New Jersey, Humana Press. W.S. Stone, S.V. Faraone, M.T. Tsuang (Eds.).
24. Kremen W.S., Seidman L.J., et al. Heterogeity of schizophrenia: a study of individual neuropsychological profiles. Schizophrenia Research 2004, 71:307-321.
25. Meehl P.E. Schizotaxia, schizotypy, schizophrenia. American Psychologist 1962, 17:827-838.
26. Meehl P.E. Schizotaxia revisited. Archives of General Psychiatry 1989, 46:935-944.
27. Nurnberger J.I., Blehar M.C, et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. Archives of General Psychiatry 1994, 51:849-859.
28. Penn D.L., Sanna L.J., et al. Social cognition in schizophrenia: an overview. Schizophrenia Bulletin 2008, 34:408-411.
29. Rybakowski J.K., Drozdz W., Borkowska A. Long-term administration of low-dose risperidone in schizotaxia subjects. Human Psychopharmacology 2007, 22:407-412.
30. Seidman L.J., Cassens G.P., et al. Neuropsychology of schizophrenia. Clinical Syndromes in Adult Neuropsychology: The Practitioner's Handbook 1992, 381-449. Elsevier Science Publishers B.V. R.F. White (Ed.).
31. Seidman L.J., Giuliano A.J., et al. Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside adolescent high risk studies. Schizophrenia Bulletin 2006, 35:507-524.
32. Seidman L.J., Pantelis C., et al. A review and a new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a MRI morphometric family study of the parahippocampal gyrus. Schizophrenia Bulletin 2003, 29:803-808.
33. Snitz B.E, MacDonald A.W., et al. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophrenia Bulletin 2006, 32:179-194.
34. SPSS SPSS for Windows, Rel. 16 2008, SPSS Inc., Chicago.
35. Stone W.S., Faraone S.V., et al. Concurrent validation of schizotaxia: a pilot study. Biological Psychiatry 2001, 50(6):434-440.
36. Stone W.S, Faraone S.V., et al. Searching for the liability to schizophrenia: concepts and methods underlying genetic high-risk studies of adolescents. Journal of Child and Adolescent Psychopharmacology 2005, 15(3):403-417.
37. Stone W.S., Hsi X. Declarative memory deficits and schizophrenia: problems and prospects. Neurobiology of Learning and Memory 2011, 96(4):544-552.
38. Susan Whitfield-Gabrieli S., Thermenos H.W., et al. Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proceedings of the National Academy of Science of the United States of America 2009, 106:1279-1284.
39. Tsuang M.T., Stone W.S., et al. Prevention of schizophrenia. Expert Review of Neurotherapeutics 2010, 10:1165-1174.
40. Tsuang M.T, Stone W.S., et al. Towards reformulating the diagnosis of schizophrenia. American Journal of Psychiatry 2000, 147:1041-1050.
41. Tsuang M.T., Stone W.S., et al. Gene-environment interactions in mental disorders: a current view. The Impact of the Environment on Psychiatric Disorder 2008, 27-51. Routledge, London. H. Freeman, S. Stansfeld (Eds.).
42. Tsuang M.T., Stone W.S., et al. Treatment of nonpsychotic relatives of patients with schizophrenia: four case studies. Biological Psychiatry 1999, 41:1412-1418.
43. Tsuang M.T, Stone W.S., et al. An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and prevention. Schizophrenia Research 2002, 54(1-2):169-175.
44. Tsuang M.T., Stone W.S., et al. Treatment of nonpsychotic relatives of patients with schizophrenia: six case studies. American Journal of Medical Genetics (Neuropsychiatric Genetics) 2002, 114(8):943-948.
45. Turetsky B.I., Calkins M.E., et al. Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures. Schizophrenia Bulletin 2007, 33:69-94.
46. Weissman M.M, Bothwell S. Assessment of social adjustment by patient self-report. Archives of General Psychiatry 1976, 33:1111-1115.