A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid-polymer hybrid nanoparticles

International Journal of Pharmaceutics

Volumn 424, Issue 1-2, 2012, Pages 98-106

  Wang, Yajie ^a   Kho, Katherine ^a   Cheow, Wean Sin ^a   Hadinoto, Kunn ^a  

^a Nanyang Technological University   (Singapore)

Author keywords

Dry powder inhaler; Hybrid nanoparticles; Leucine; Spray drying; Spray freeze drying

Indexed keywords

LEUCINE; LEVOFLOXACIN; LIPID; MANNITOL; NANOPARTICLE; PHOSPHATIDYLCHOLINE; POLYGLACTIN; POLYMER; POLYVINYL ALCOHOL;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FREEZE DRYING; HYDROPHOBICITY; INTERMETHOD COMPARISON; PARTICLE SIZE; POWDER INHALER; PRIORITY JOURNAL; SPRAY DRYING; SPRAY FREEZE DRYING;

DESICCATION; DRUG COMPOUNDING; DRY POWDER INHALERS; EXCIPIENTS; FREEZE DRYING; LACTIC ACID; LECITHINS; LEUCINE; MANNITOL; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; OFLOXACIN; POLYGLYCOLIC ACID; POLYVINYL ALCOHOL;

EID: 84862776736     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.12.045     Document Type: Article

References (22)

1. A. Bershteyn, J. Chaparro, R. Yau, M. Kim, E. Reinherz, L. Ferreira-Moita, and D.J. Irvine Polymer-supported lipid shells, onions, and flowers Soft Matter 4 2008 1787 1791
2. W.S. Cheow, and K. Hadinoto Factors affecting drug encapsulation and stability of lipid-polymer hybrid nanoparticles Colloids Surf. B: Biointerfaces 85 2011 214 220
3. W.S. Cheow, M.L.L. Ng, K. Kho, and K. Hadinoto Spray-freeze-drying production of thermally sensitive polymeric nanoparticle aggregates for inhaled drug delivery: effect of freeze-drying adjuvants Int. J. Pharm. 404 2011 289 300
4. E. D'Aurizio, C.F. van Nostrum, M.J. van Steenbergen, P. Sozio, F. Siepmann, J. Siepmann, W.E. Hennink, and A. Di Stefano Preparation and characterization of poly(lactic-co-glycolic acid) microspheres loaded with a labile antiparkinson prodrug Int. J. Pharm. 409 2011 289 296
5. J.H. Finley Spectrophotometric determination of polyvinyl alcohol in paper coatings Anal. Chem. 33 1961 1925 1927
6. C.-M.J. Hu, S. Kaushal, H.S.T. Cao, S. Aryal, M. Sartor, S. Esener, M. Bouvet, and L. Zhang Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells Mol. Pharmacol. 7 2010 914 920
7. D.M.K. Jensen, D. Cun, M.J. Maltesen, S. Frokjaer, H.M. Nielsen, and C. Foged Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation J. Control. Release 142 2010 138 145
8. K. Kho, and K. Hadinoto Aqueous re-dispersibility characterization of spray-dried hollow spherical silica nano-aggregates Powder Technol. 198 2010 354 363
9. K. Kho, and K. Hadinoto Optimizing aerosolization efficiency of dry-powder aggregates of thermally-sensitive polymeric nanoparticles produced by spray-freeze-drying Powder Technol. 214 2011 169 176
10. M.D. Louey, M. Van Oort, and A.J. Hickey Standardized entrainment tubes for the evaluation of pharmaceutical dry powder dispersion J. Aerosol Sci. 37 2006 1520 1531 (Pubitemid 44635527)
11. K. Ohashi, T. Kabasawa, T. Ozeki, and H. Okada One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis J. Control. Release 135 2009 19 24
12. P.G.A. Rogueda, and D. Traini The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects Expert Opin. Drug Deliv. 4 2007 595 606 (Pubitemid 350193398)
13. R. Salama, S. Hoe, H.K. Chan, D. Traini, and P.M. Young Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: influence of polymer concentration on physical and in vitro characteristics Eur. J. Pharm. Biopharm. 69 2008 486 495
14. J. Sanchez Colorimetric assay of alditols in complex biological samples J. Agric. Food Chem. 46 1998 157 160 (Pubitemid 128488037)
15. D.M. Small Phase equilibria and structure of dry and hydrated egg lecithin J. Lipid Res. 8 1967 551 557
16. X.F. Su, J. Fricke, D.G. Kavanagh, and D.J. Irvine In vitro and in vivo mRNA delivery using lipid-enveloped ph-responsive polymer nanoparticles Mol. Pharmacol. 8 2011 774 787
17. J. Sung, D. Padilla, L. Garcia-Contreras, J. VerBerkmoes, D. Durbin, C. Peloquin, K. Elbert, A. Hickey, and D. Edwards Formulation and pharmacokinetics of self-assembled rifampicin nanoparticle systems for pulmonary delivery Pharm. Res. 26 2009 1847 1855
18. Y. Takashima, R. Saito, A. Nakajima, M. Oda, A. Kimura, T. Kanazawa, and H. Okada Spray-drying preparation of microparticles containing cationic PLGA nanospheres as gene carriers for avoiding aggregation of nanospheres Int. J. Pharm. 343 2007 262 269 (Pubitemid 47321027)
19. K. Tomoda, T. Ohkoshi, K. Hirota, G.S. Sonavane, T. Nakajima, H. Terada, M. Komuro, K. Kitazato, and K. Makino Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer Colloids Surf. B: Biointerfaces 71 2009 177 182
20. A. Wade, and P.J. Weller Handbook of Pharmaceutical Excipients 2nd edition 1994 American Pharmaceutical Association Washington DC
21. L. Zhang, J.M. Chan, F.X. Gu, J.-W. Rhee, A.Z. Wang, A.F. Radovic-Moreno, F. Alexis, R. Langer, and O.C. Farokhzad Self-assembled lipid-polymer hybrid nanoparticles: a robust drug delivery platform ACS Nano 2 2008 1696 1702
22. Y. Zheng, B. Yu, W. Weecharangsan, L. Piao, M. Darby, Y. Mao, R. Koynova, X. Yang, H. Li, S. Xu, L.J. Lee, Y. Sugimoto, R.W. Brueggemeier, and R.J. Lee Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7[alpha]-APTADD to breast cancer cells Int. J. Pharm. 390 2010 234 241