Optimizing aerosolization efficiency of dry-powder aggregates of thermally-sensitive polymeric nanoparticles produced by spray-freeze-drying

Powder Technology

Volumn 214, Issue 1, 2011, Pages 169-176

  Kho, Katherine ^a   Hadinoto, Kunn ^a  

^a Nanyang Technological University   (Singapore)

Author keywords

Aerosols; Aggregates; Dry powder inhaler; Nanoparticles; Spray freeze drying

Indexed keywords

AEROSOLIZATION; AGGREGATE STRUCTURES; AQUEOUS ENVIRONMENT; DOSAGE FORMS; DRY POWDER INHALER; FEED CONCENTRATION; FEED-RATES; FINE PARTICLE FRACTIONS; FLOWABILITY; HYDROPHILIC AND HYDROPHOBIC; MASS MEDIAN AERODYNAMIC DIAMETERS; MATRIX; MICRO-SCALES; OPTIMAL CONDITIONS; POLYMERIC NANOPARTICLES; PROCESS PARAMETERS; PRODUCTION YIELD; SPRAY FREEZE DRYING; THERAPEUTIC FUNCTIONS;

AEROSOLS; AMINO ACIDS; DRYING; EFFICIENCY; FUNCTIONAL POLYMERS; LOW TEMPERATURE DRYING; NANOPARTICLES; OPTIMIZATION;

AGGREGATES;

LEUCINE; MANNITOL; NANOPARTICLE; POLYCAPROLACTONE;

AEROSOL; ARTICLE; CONTROLLED STUDY; DRY POWDER; FREEZE DRYING; HYDROPHILICITY; HYDROPHOBICITY; MATHEMATICAL MODEL; MELTING POINT; PARTICLE SIZE; POWDER INHALER; PROCESS OPTIMIZATION; SPRAY DRYING; SUSPENSION; TEMPERATURE SENSITIVITY;

EID: 80052808930     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2011.08.010     Document Type: Article

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