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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 5, 2012, Pages 1953-1957

3,4-Diarylpiperidines as potent renin inhibitors

(18) Lacombe, Patrick a Arbour, Mélissa a Aspiotis, Renée a Cauchon, Elizabeth a Chen, Austin a Dubé, Daniel a Falgueyret, Jean Pierre a Fournier, Pierre André a Gallant, Michel a Grimm, Erich a Han, Yongxin a Juteau, Hélne a Liu, Suzanna a Mellon, Christophe a Ramtohul, Yeeman a Simard, Daniel a St Jacques, René a Tsui, Gavin Chit a

a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH (Canada)

Author keywords

Anti hypertensive; Inhibitor; Renin

Indexed keywords

3,4 DIARYLPIPERIDINE DERIVATIVE; ANTIHYPERTENSIVE AGENT; CYTOCHROME P450 3A4; RENIN; RENIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERTENSION; IC 50; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRANSGENIC RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL AVAILABILITY; CYTOCHROME P-450 CYP3A; DOGS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; HYPERTENSION; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RENIN; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; RATTUS;

EID: 84862776596 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.01.044 Document Type: Article

Times cited : (8)

References (23)

1
- 84862791757
- American Heart Association, Statistics: 2007.
- American Heart Association, Statistics: 2007.

2
- 33646251621
- A. Ferro, R. Gilbert, and H. Krum Int. J. Clin. Pract. 60 2006 577
- (2006) Int. J. Clin. Pract. , vol.60 , pp. 577
- Ferro, A.¹ Gilbert, R.² Krum, H.³

3
- 0027077499
- M.A. Weber Am. J. Hypertens. 5 1992 247S
- (1992) Am. J. Hypertens. , vol.5
- Weber, M.A.¹

4
- 7944222897
- M.E. Cooper Am. J. Hypertens. 17 2004 16S
- (2004) Am. J. Hypertens. , vol.17
- Cooper, M.E.¹

5
- 2342475192
- K. Norris, and C. Vaughn Expert Rev. Cardiovasc. Ther. 1 2003 51
- (2003) Expert Rev. Cardiovasc. Ther. , vol.1 , pp. 51
- Norris, K.¹ Vaughn, C.²

6
- 33747486317
- H. Cheng, and R.C. Harris Expert Opin. Drug Saf. 5 2006 631
- (2006) Expert Opin. Drug Saf. , vol.5 , pp. 631
- Cheng, H.¹ Harris, R.C.²

7
- 33750235228
- E. O'Brien Expert Opin. Investig. Drugs 15 2006 1269
- (2006) Expert Opin. Investig. Drugs , vol.15 , pp. 1269
- O'Brien, E.¹

8
- 33748070612
- D.N. Müller, and F.C. Luft Clin. J. Am. Soc. Nephrol. 1 2006 221
- (2006) Clin. J. Am. Soc. Nephrol. , vol.1 , pp. 221
- Müller, D.N.¹ Luft, F.C.²

9
- 77957590370
- M. Azizi, A.H. Gradman, and P.S. Sever J. R. A. A. System 10 2009 65
- (2009) J. R. A. A. System , vol.10 , pp. 65
- Azizi, M.¹ Gradman, A.H.² Sever, P.S.³

10
- 0025360877
- W.J. Greenlee Med. Res. Rev. 10 1990 173
- (1990) Med. Res. Rev. , vol.10 , pp. 173
- Greenlee, W.J.¹

11
- 0029436599
- S.H. Rosenberg Prog. Med. Chem. 32 1995 37
- (1995) Prog. Med. Chem. , vol.32 , pp. 37
- Rosenberg, S.H.¹

12
- 33846340818
- C.M. Tice Annu. Rep. Med. Chem. 41 2006 155
- (2006) Annu. Rep. Med. Chem. , vol.41 , pp. 155
- Tice, C.M.¹

13
- 75449118659
- D.L. Feldman, and J. Maibaum Annu. Rep. Med. Chem. 44 2009 105
- (2009) Annu. Rep. Med. Chem. , vol.44 , pp. 105
- Feldman, D.L.¹ Maibaum, J.²

14
- 77957562386
- P. Lacombe, R. Aspiotis, C. Bayly, A. Chen, D. Dubé, L. Dubé, S. Gagné, M. Gallant, M. Gaudreault, E. Grimm, R. Houle, H. Juteau, J.F. Lévesque, S. Liu, D. McKay, P. Roy, S. Toulmond, and T. Wu Bioorg. Med. Chem. Lett. 20 2010 5822
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 5822
- Lacombe, P.¹ Aspiotis, R.² Bayly, C.³ Chen, A.⁴ Dubé, D.⁵ Dubé, L.⁶ Gagné, S.⁷ Gallant, M.⁸ Gaudreault, M.⁹ Grimm, E.¹⁰ Houle, R.¹¹ Juteau, H.¹² Lévesque, J.F.¹³ Liu, S.¹⁴ McKay, D.¹⁵ Roy, P.¹⁶ Toulmond, S.¹⁷ Wu, T.¹⁸

15
- 77955660765
- A. Chen, D. Dubé, L. Dubé, S. Gagné, M. Gallant, M. Gaudreault, E. Grimm, R. Houle, P. Lacombe, S. Laliberté, S. Liu, D. MacDonald, B. Mackay, D. Martin, D. McKay, and J.F. Powell, Lévesque Bioorg. Med. Chem. Lett. 20 2010 5074
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 5074
- Chen, A.¹ Dubé, D.² Dubé, L.³ Gagné, S.⁴ Gallant, M.⁵ Gaudreault, M.⁶ Grimm, E.⁷ Houle, R.⁸ Lacombe, P.⁹ Laliberté, S.¹⁰ Liu, S.¹¹ MacDonald, D.¹² MacKay, B.¹³ Martin, D.¹⁴ McKay, D.¹⁵ Powell Lévesque, J.F.¹⁶

16
- 77957887804
- O. Corminboeuf, O. Bezenon, C. Grisostomi, L. Remen, S. Richard-Bildstein, D. Bur, L. Prade, P. Hess, P. Strickner, W. Fischli, B. Steiner, and A. Treiber Bioorg. Med. Chem. Lett. 20 2010 6286
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 6286
- Corminboeuf, O.¹ Bezenon, O.² Grisostomi, C.³ Remen, L.⁴ Richard-Bildstein, S.⁵ Bur, D.⁶ Prade, L.⁷ Hess, P.⁸ Strickner, P.⁹ Fischli, W.¹⁰ Steiner, B.¹¹ Treiber, A.¹²

17
- 77957868394
- O. Corminboeuf, O. Bezenon, L. Remeň, C. Grisostomi, S. Richard-Bildstein, D. Bur, L. Prade, P. Strickner, P. Hess, W. Fischli, B. Steiner, and A. Treiber Bioorg. Med. Chem. Lett. 20 2010 6291
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 6291
- Corminboeuf, O.¹ Bezenon, O.² Remeň, L.³ Grisostomi, C.⁴ Richard-Bildstein, S.⁵ Bur, D.⁶ Prade, L.⁷ Strickner, P.⁸ Hess, P.⁹ Fischli, W.¹⁰ Steiner, B.¹¹ Treiber, A.¹²

18
- 84862791760
- US2009/270369 A1
- Ozaki, F.; Ishida, T.; Soejima, M.; Norimine, Y.; Yamamoto, N.; Kobayashi, K.; Hasegawa, D.; Kaneko, T.; Doi, E.; Kurusu, N. US2009/270369 A1, 2009.
- (2009)
- Ozaki, F.¹ Ishida, T.² Soejima, M.³ Norimine, Y.⁴ Yamamoto, N.⁵ Kobayashi, K.⁶ Hasegawa, D.⁷ Kaneko, T.⁸ Doi, E.⁹ Kurusu, N.¹⁰

19
- 38349133083
- T.J. Colacot, and G.A. Grasa Org. Lett. 9 2007 5489
- (2007) Org. Lett. , vol.9 , pp. 5489
- Colacot, T.J.¹ Grasa, G.A.²

20
- 0027324502
- Y. Lu, C. Miet, N. Kunesh, and J.E. Poisson Tetrahedron Asymmetry 4 1993 893
- (1993) Tetrahedron Asymmetry , vol.4 , pp. 893
- Lu, Y.¹ Miet, C.² Kunesh, N.³ Poisson, J.E.⁴

21
- 79958695576
- A. Chen, E. Cauchon, A. Chefson, S. Dolman, Y. Ducharme, D. Dubé, J.-P. Falgueyret, P.-A. Fournier, S. Gagné, M. Gallant, E. Grimm, Y. Han, R. Houle, J.-Q. Huang, G. Hugues, H. Juteau, P. Lacombe, S. Lauzon, J.-F. Lévesque, S. Liu, D. MacDonald, B. Mackay, D. McKay, D. Percival, R. St-Jacques, and S. Toulmond Bioorg. Med. Chem. Lett. 21 2011 3970
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3970
- Chen, A.¹ Cauchon, E.² Chefson, A.³ Dolman, S.⁴ Ducharme, Y.⁵ Dubé, D.⁶ Falgueyret, J.-P.⁷ Fournier, P.-A.⁸ Gagné, S.⁹ Gallant, M.¹⁰ Grimm, E.¹¹ Han, Y.¹² Houle, R.¹³ Huang, J.-Q.¹⁴ Hugues, G.¹⁵ Juteau, H.¹⁶ Lacombe, P.¹⁷ Lauzon, S.¹⁸ Lévesque, J.-F.¹⁹ Liu, S.²⁰ more..

22
- 79958756483
- A. Chen, L.-C. Campeau, E. Cauchon, A. Chefson, Y. Ducharme, D. Dubé, J.-P. Falgueyret, P.-A. Fournier, S. Gagné, E. Grimm, Y. Han, R. Houle, J.-Q. Huang, P. Lacombe, S. Laliberté, J.-F. Lévesque, S. Liu, D. MacDonald, B. Mackay, D. McKay, D. Percival, C. Regan, H. Regan, S. Stump, and S. Toulmond Bioorg. Med. Chem. Lett. 21 2011 3976
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3976
- Chen, A.¹ Campeau, L.-C.² Cauchon, E.³ Chefson, A.⁴ Ducharme, Y.⁵ Dubé, D.⁶ Falgueyret, J.-P.⁷ Fournier, P.-A.⁸ Gagné, S.⁹ Grimm, E.¹⁰ Han, Y.¹¹ Houle, R.¹² Huang, J.-Q.¹³ Lacombe, P.¹⁴ Laliberté, S.¹⁵ Lévesque, J.-F.¹⁶ Liu, S.¹⁷ MacDonald, D.¹⁸ MacKay, B.¹⁹ McKay, D.²⁰ more..

23
- 81255192119
- 10.1016/j.bmcl.2011.10.013
- A. Chen, R. Aspiotis, L.-C. Campeau, E. Cauchon, A. Chefson, Y. Ducharme, J.-P. Falgueyret, S. Gagné, Y. Han, R. Houle, S. Laliberté, G. Larouche, J.-F. Lévesque, D. McKay, and D. Percival Bioorg. Med. Chem. Lett. 2011 21 10.1016/j.bmcl.2011.10.013
- (2011) Bioorg. Med. Chem. Lett. , pp. 21
- Chen, A.¹ Aspiotis, R.² Campeau, L.-C.³ Cauchon, E.⁴ Chefson, A.⁵ Ducharme, Y.⁶ Falgueyret, J.-P.⁷ Gagné, S.⁸ Han, Y.⁹ Houle, R.¹⁰ Laliberté, S.¹¹ Larouche, G.¹² Lévesque, J.-F.¹³ McKay, D.¹⁴ Percival, D.¹⁵

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